Patents by Inventor Eugine LEE

Eugine LEE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR MODULATING MYC EXPRESSION
    Publication number: 20240132559
    Abstract: The present disclosure relates to compositions and methods for reducing expression of MYC gene in a cell. In some embodiments, an expression repressor comprises a targeting moiety that binds a MYC promoter, anchor sequence, or super-enhancer. In some embodiments, the expression repressor comprises an effector moiety that represses transcription or methylates DNA. Systems comprising two expression repressors are also disclosed. The compositions can be used, for example, to treat cancers such as HCC or NSCLC.
    Type: Application
    Filed: December 15, 2021
    Publication date: April 25, 2024
    Inventors: Abigail Elizabeth WITT, Jeremiah Dale FARELLI, Adam Walter SCHEIDEGGER, William Thomas SENAPEDIS, Jr., Jodi Michelle KENNEDY, Houda BELAGHZAL, Defne YARAR, Eugine LEE
  • Oxazole and thiazole compounds as beta-catenin modulators and uses thereof
    Patent number: 9173871
    Abstract: A series of oxazole and thiazole compounds are shown herein to be small molecule inhibitors of the Wnt pathway that specifically target the activity of the stabilized pool of ?-catenin. Oxazole and thiazole compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, cancer, and others.
    Type: Grant
    Filed: April 17, 2012
    Date of Patent: November 3, 2015
    Assignee: New York University
    Inventors: Ramanuj Dasgupta, Foster Gonsalves, Susan Katherine Logan, Eugine Lee
  • OXAZOLE AND THIAZOLE COMPOUNDS AS BETA-CATENIN MODULATORS AND USES THEREOF
    Publication number: 20120264744
    Abstract: A series of oxazole and thiazole compounds are shown herein to be small molecule inhibitors of the Wnt pathway that specifically target the activity of the stabilized pool of ?-catenin. Oxazole and thiazole compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, cancer, and others.
    Type: Application
    Filed: April 17, 2012
    Publication date: October 18, 2012
    Inventors: Ramanuj DASGUPTA, Foster GONSALVES, Susan Katherine LOGAN, Eugine LEE