Abstract: The present invention relates to an anti-tumor adenovirus and an anticancer composition comprising same. Double-stranded siRNA of the present invention simultaneously inhibits the expression of a first nucleic acid and a second nucleic acid, thus promoting the death of cancer cells, exhibits more remarkable anticancer activity as compared to co-treatment of respective siRNAs, has a synergistic effect of improving cancer cell death in combined treatment with an anticancer agent. The adenovirus comprising a shRNA-encoding expression cassette expressing the double-stranded siRNA, and a hTERT promoter evades immune responses in the body and is specifically delivered to cancer cells, thus having a systemic therapeutic effect, can be locally delivered, has excellent selectivity, and exhibits a significant anticancer effect even in minimally invasive treatment, and thus, the adenovirus can be effectively used as an anticancer composition or an anticancer adjuvant in various carcinomas.

Abstract: Disclosed are earplugs capable of providing a good feel when worn, buffering external impact, and blocking noise or controlling the volume of the noise coming in from the outside. The earplugs comprise: a main body having a small cross-sectional part and an extended part; and an ear pad, which is mounted on the outer circumferential surface of the small cross-sectional part, comes into contact with the inner circumferential surface of an ear canal when worn in an ear, and blocks the gap between the outer circumferential surface of the small cross-sectional part and the inner circumferential surface of the ear canal, the earplugs also comprising a flexible part, which is installed between the small cross-sectional part and the extended part and allows the adjustment of the position of the extended part with respect to the small cross-sectional part.