Abstract: Provided is a composition comprising sonosensitive liposomes for penetrating the blood-brain barrier, wherein the sonosensitive liposomes have excellent drug loading efficiency and ultrasound-induced drug release effect and can effectively penetrating the blood-brain barrier during ultrasound stimulation, and the sonosensitive liposomes can circulate in the body for a long time, and thus have better blood-brain barrier penetration efficiency, a high affinity for brain tumor cells, and excellent delivery effect to tumor sites and can be used as a drug delivery system for delivering brain disease therapeutic agents and the like to the brain.

Abstract: The present invention relates to an immune checkpoint inhibitor conjugated with an sonosensitizer, a use thereof, and the like. The immune checkpoint inhibitor conjugate conjugated with an sonosensitizer according to the present invention has selectivity for tumors with respect to targeted therapy and specifically responds to ultrasonic waves, and thus can be used to produce drugs for diagnosing and treating cancer. Particularly, the conjugate of the present invention exhibits excellent solubility and stability in an aqueous solution, and provides excellent anticancer effects as compared with simple immune checkpoint inhibitors, and therefore, is expected to be useful as a novel drug for treating cancer.

Abstract: The present invention relates to novel microspheres using an anionic polymer, a preparation method thereof, a composition, and the like, and the present invention is used for a method for performing a vascular embolization and/or necrosing cancer cells by blocking major blood vessels that supply nutrients to cancer cells to induce an embolic effect, and thus may be used for the treatment of patients with cancer.

Abstract: The present invention relates to novel nanoparticles using an anionic polymer, a preparation method thereof, a composition, and the like, and the present invention is used for a method of necrosing cancer cells by blocking major blood vessels that supply nutrients to cancer cells to induce an embolic effect, and thus may be used for the treatment of patients with cancer.

Abstract: The present invention relates to a sonosensitive liposome and a method for preparing same, and the sonosensitive liposome, according to the present invention, increases the delivery efficiency of an encapsulated drug and, by being used in combination with sonication, is expected to exhibit various functions in the field of cancer treatment and drug delivery carriers through an improved drug delivery effect by means of targeting cancer cells.

Abstract: The present invention aims to dramatically increase the effect of hepatic arterial chemoembolization by developing human serum albumin-based nanoparticles, which are bioproteins that effectively carry Adriamycin in place of Adriamycin, an anticancer agent used in hepatic arterial chemoembolization. The human serum albumin nanoparticles carrying the Adriamycin not only intensively infiltrate the drug effectively into the cells but also have a synergistic effect that can induce a long-term therapeutic effect by utilizing the effect of continuous drug release from the particles.

Abstract: Provided is an immune microbubble complex, and a use thereof. An immune-microbubble complex (IMC) according to the presently claimed subject matter includes microbubbles to which an antibody is conjugated, in which the microbubbles have excellent stability and excellent antibody binding strength, and it was confirmed that, when the immune-microbubble complex is treated with high-intensity focused ultrasound (HIFU), an anti-tumor effect is significantly increased and an immune-enhancing effect is exhibited. Therefore, the immune-microbubble complex according to the presently claimed subject matter is expected to increase the efficiency of delivering the conjugated antibody and be used in both diagnosis and treatment of cancer, and exhibit various functions in the field of immunotherapy, including a contrast effect, half-life improvement, improved drug delivery, a lymphocyte concentration effect, cancer immunotherapy and induction of immunotherapy using ultrasound.

Abstract: The present invention relates to novel nanoparticles using an anionic polymer, a preparation method thereof, a composition, and the like, and the present invention is used for a method of necrosing cancer cells by blocking major blood vessels that supply nutrients to cancer cells to induce an embolic effect, and thus may be used for the treatment of patients with cancer.

Abstract: The present invention aims to dramatically increase the effect of hepatic arterial chemoembolization by developing human serum albumin-based nanoparticles, which are bioproteins that effectively carry Adriamycin in place of Adriamycin, an anticancer agent used in hepatic arterial chemoembolization. The human serum albumin nanoparticles carrying the Adriamycin not only intensively infiltrate the drug effectively into the cells but also have a synergistic effect that can induce a long-term therapeutic effect by utilizing the effect of continuous drug release from the particles.

Abstract: A method of frying a shrimp to maintain an original shape includes a first process of forming a plurality of slits in a lower portion of the body part of the shrimp close to a tail part thereof; a second process of removing a back shell of the body; a third process of coating the head part, the body part, plurality of leg parts, and the tail part of the shrimp from which the back shell thereof has been removed, with a powder form of primary batter; a fourth process of coating the shrimp coated with the powder form of primary batter, with a liquid type of secondary batter; and a process operation of introducing the shrimp into a fry container from an end portion of the head part by acute angle when the shrimp coated with the liquid type of secondary batter is put into the fry container.

Abstract: A method of frying a shrimp to maintain an original shape includes a first process of forming a plurality of slits in a lower portion of the body part of the shrimp close to a tail part thereof; a second process of removing a back shell of the body; a third process of coating the head part, the body part, plurality of leg parts, and the tail part of the shrimp from which the back shell thereof has been removed, with a powder form of primary batter; a fourth process of coating the shrimp coated with the powder form of primary batter, with a liquid type of secondary batter; and a process operation of introducing the shrimp into a fry container from an end portion of the head part by acute angle when the shrimp coated with the liquid type of secondary batter is put into the fry container.