Patents by Inventor Eun-Chung Park

Eun-Chung Park has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Self-rearranging DNA vectors
    Patent number: 7259009
    Abstract: Disclosed are replicatable viral DNA vectors encoding a site-specific DNA-altering enzyme and a DNA target recognized by the enzyme, the enzyme selectively converting, in a cell expressing the enzyme, the DNA vector to a rearranged form. The invention further relates to methods for assembling recombinant adenoviral DNAs. These methods include the steps of: (a) providing a first linearized DNA vector including a restriction site and a cos site and a second linearized DNA vector including the restriction site, an adenoviral nucleic acid molecule, and a cos site; and (b) ligating the first and second linearized DNA vectors, the ligation assembling a recombinant adenoviral DNA.
    Type: Grant
    Filed: March 7, 2003
    Date of Patent: August 21, 2007
    Assignee: The General Hospital Corporation
    Inventors: Brian Seed, Mason Wright Freeman, Alexander Kovtun, Masahiro Murakawa, Eun-Chung Park, Xinzhong Wang
  • Self-rearranging DNA vectors
    Publication number: 20070166286
    Abstract: Disclosed are replicatable viral DNA vectors encoding a site-specific DNA-altering enzyme and a DNA target recognized by the enzyme, the enzyme selectively converting, in a cell expressing the enzyme, the DNA vector to a rearranged form. The invention further relates to methods for assembling recombinant adenoviral DNAs. These methods include the steps of: (a) providing a first linearized DNA vector including a restriction site and a cos site and a second linearized DNA vector including the restriction site, an adenoviral nucleic acid molecule, and a cos site; and (b) ligating the first and second linearized DNA vectors, the ligation assembling a recombinant adenoviral DNA.
    Type: Application
    Filed: March 13, 2007
    Publication date: July 19, 2007
    Inventors: Brian Seed, Mason Freeman, Alexander Kovtun, Masahiro Murakawa, Eun-Chung Park, Xinzhong Wang
  • Self-rearranging DNA vectors
    Publication number: 20040028653
    Abstract: Disclosed are replicatable viral DNA vectors encoding a site-specific DNA-altering enzyme and a DNA target recognized by the enzyme, the enzyme selectively converting, in a cell expressing the enzyme, the DNA vector to a rearranged form. The invention further relates to methods for assembling recombinant adenoviral DNAs. These methods include the steps of: (a) providing a first linearized DNA vector including a restriction site and a cos site and a second linearized DNA vector including the restriction site, an adenoviral nucleic acid molecule, and a cos site; and (b) ligating the first and second linearized DNA vectors, the ligation assembling a recombinant adenoviral DNA.
    Type: Application
    Filed: March 7, 2003
    Publication date: February 12, 2004
    Inventors: Brian Seed, Mason Wright Freeman, Alexander Kovtun, Masahiro Murakawa, Eun-Chung Park, Xinzhong Wang
  • Transferrin receptor specific ligand-neuropharmaceutical agent fusion proteins
    Patent number: 5977307
    Abstract: The present invention pertains to a method for delivering a neuropharmaceutical agent across the blood brain barrier to the brain of a host. The method comprises administering to the host a therapeutically effective amount of a ligand-neuropharmaceutical agent fusion protein wherein the ligand is reactive with a brain capillary endothelial cell receptor. Other aspects of this invention include a delivery system comprising a ligand reactive with a brain capillary endothelial cell receptor which has formed a fusion protein with a neuropharmaceutical agent. The fusion proteins are also aspects of this invention.
    Type: Grant
    Filed: February 13, 1996
    Date of Patent: November 2, 1999
    Assignees: Alkermes, Inc., The Regents of the University of California
    Inventors: Phillip M. Friden, Ruth M. Starzyk, Sherie L. Morrison, Eun-Chung Park, John P. McGrath
  • Transferrin neuropharmaceutical agent fusion protein
    Patent number: 5672683
    Abstract: The present invention pertains to a method for delivering a neuropharmaceutical agent across the blood brain barrier to the brain of a host. The method comprises administering to the host a therapeutically effective amount of a ligand-neuropharmaceutical agent fusion protein wherein the ligand is reactive with a brain capillary endothelial cell receptor. Other aspects of this invention include a delivery system comprising a ligand reactive with a brain capillary endothelial cell receptor which has formed a fusion protein with a neuropharmaceutical agent. The fusion proteins are also aspects of this invention.
    Type: Grant
    Filed: July 16, 1993
    Date of Patent: September 30, 1997
    Assignees: Alkermes, Inc., The Regents of the University of California
    Inventors: Phillip M. Friden, Ruth M. Starzyk, Sherie L. Morrison, Eun-Chung Park