Abstract: The present disclosure relates to an isolated anti-FcRN antibody, which is an antibody binding to FcRN (stands for neonatal Fc receptor, also called FcRP, FcRB or Brambell receptor) that is a receptor with a high affinity for IgG or a fragment thereof, a method of preparing thereof, a composition for treating autoimmune disease, which comprises the antibody, and a method of treating and diagnosing autoimmunre diseases using the antibody. The FcRn-specific antibody according to the present disclosure binds to FcRn non-competitively with IgG to reduce serum pathogenic auto-antibody levels, and thus can be used for the treatment of autoimmune diseases.

Abstract: Methods and systems for identifying epileptogenic regions of the brain and locating seizure foci can use only interictal EEG data. These methods and systems enable a physician to locate seizure foci without having to wait for a patient to experience a seizure and have it recorded. A network causality analysis can be applied to the interictal EEG data to determine the causal nodes, the nodes influenced by the causal nodes and the causal connection or link between the nodes. The most influential causal nodes can be ranked and used to generate a map of causal links in the brain networks to accelerate the identification of the epileptogenic regions of the brain and the location seizure focus.