Abstract: The present disclosure provides a method of monitoring total protein acetylation in a cell exposed to an HDAC inhibitor that involves first contacting a cell that has been exposed to an HDAC inhibitor with a plurality of reagents that each recognize and bind to a nuclear or cytoplasmic acetylated protein. The bound reagent is then detected using a detection assay and the level of the detected bound reagent is compared to a control, thereby monitoring total protein acetylation in the cell.

Abstract: The invention provides compositions and methods for inhibiting cell motility, metastatic cancer and viral infections in a mammal that involve increasing the activity or expression of MxA.