Patents by Inventor Eun Joo Nam

Eun Joo Nam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230174617
    Abstract: The present invention relates to a novel immunoglobulin Fc domain variant protein and use thereof, and when expressed in the form of a fusion protein with another biologically active protein, an immunoglobulin Fc domain variant protein according to an embodiment of the present invention can prolong the half-life in vivo of the biologically active protein as well as effectively suppress effector functions such as ADCC or CDC to minimize unexpected side effects.
    Type: Application
    Filed: May 14, 2020
    Publication date: June 8, 2023
    Inventors: Hyun-Tak JIN, Eun Joo NAM, Je-In YOUN
  • Patent number: 11339197
    Abstract: A modified EGF protein, a production method therefor, and a use thereof are disclosed. The modified EGF protein allows an effective delivery of EGF into the cell and exhibits an enhanced half-life span. A method for producing the modified EGF protein includes culturing conditions where host cell growth phase and protein expression phase employ different temperature conditions. A use of the modified EGF protein is also disclosed.
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: May 24, 2022
    Assignee: PROGEN CO., LTD.
    Inventors: Zungyoon Yang, Eun Joo Nam
  • Publication number: 20220096589
    Abstract: A treatment of cervical tumor caused by human papillomavirus (HPV) infection is disclosed. Methods for improving treatment of cervical tumor caused by HPV infection are also disclosed. The methods include administering a polynucleotide encoding an E6/E7 fusion protein to a subject suffering from cervical tumor caused by HPV. The cervical tumor may be squamous cell carcinoma (SCC), adenocarcinoma, adenosquamous carcinoma, small cell carcinoma, neuroendocrine tumor (NET), glassy cell carcinoma, villoglandular adenocarcinoma (VGA), non-carcinoma malignancies, melanoma, lymphoma, or cervical intraepithelial neoplasia (CIN).
    Type: Application
    Filed: August 27, 2021
    Publication date: March 31, 2022
    Applicant: GENEXINE, INC.
    Inventors: Hyun-Tak JIN, Hye Seong LIM, You Suk SUH, Eun Joo NAM
  • Patent number: 11135262
    Abstract: This invention relates to the treatment of cervical tumor caused by human papillomavirus (HPV) infection. In particular, the invention provides methods for improving cervical tumor treatment and methods for treating cervical tumor caused by HPV infection using a polynucleotide encoding an E6/E7 fusion protein.
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: October 5, 2021
    Assignee: GENEXINE, INC.
    Inventors: Hyun-Tak Jin, Hye Seong Lim, You Suk Suh, Eun Joo Nam
  • Publication number: 20210188931
    Abstract: A modified EGF protein, a production method therefor, and a use thereof are disclosed. The modified EGF protein allows an effective delivery of EGF into the cell and exhibits an enhanced half-life span. A method for producing the modified EGF protein includes culturing conditions where host cell growth phase and protein expression phase employ different temperature conditions. A use of the modified EGF protein is also disclosed.
    Type: Application
    Filed: October 23, 2018
    Publication date: June 24, 2021
    Applicant: PROGEN CO., LTD.
    Inventors: Zungyoon YANG, Eun Joo NAM
  • Publication number: 20170304385
    Abstract: This invention relates to the treatment of cervical tumor caused by human papillomavirus (HPV) infection. In particular, the invention provides methods for improving cervical tumor treatment and methods for treating cervical tumor caused by HPV infection using a polynucleotide encoding an E6/E7 fusion protein.
    Type: Application
    Filed: August 14, 2015
    Publication date: October 26, 2017
    Applicant: GENEXINE, Inc.
    Inventors: Hyun-Tak JIN, HYE SEONG LIM, YOU SUK SUH, EUN JOO NAM
  • Publication number: 20160108105
    Abstract: Disclosed is a human IgG4 Fc polypeptide variant, including a modified CH2 domain of human IgG4 Fc, wherein the modification contains a replacement of a 6-20 consecutive amino acid sequence from the N-terminus of the CH2 domain of IgG4 with a 4-18 consecutive amino acid sequence from the N-terminus of human IgA1 CH2, a 4-18 consecutive amino acid sequence from the N-terminus of human IgA2 CH2, a 4-18 consecutive amino acid sequence from the N-terminus of human IgD CH2, a 4-18 consecutive amino acid sequence from the N-terminus of human IgE CH2, or a 4-18 consecutive amino acid sequence from the N-terminus of human IgM CH2. The Fc variant imparts to a biologically active polypeptide—the modified Fc variant with a prolonged in-vivo half-life and reduced immunogenic reaction.
    Type: Application
    Filed: October 6, 2015
    Publication date: April 21, 2016
    Applicant: GENEXINE, INC.
    Inventors: Se Hwan YANG, Eun Ju SHIN, Jaehan PARK, Eun Joo NAM
  • Patent number: 8580848
    Abstract: The present invention relates to the novel benzofuran derivatives, the preparation thereof and the composition comprising the same. The benzofuran derivatives of the present invention showed potent inhibiting activity of beta-amyloid aggregation and cell cytotoxicity resulting in stimulating the proliferation of neuronal cells as well as recovering activity of memory learning injury caused by neuronal cell injury using transformed animal model with beta-amyloid precursor gene, therefore the compounds can be useful in treating or preventing cognitive function disorder.
    Type: Grant
    Filed: June 5, 2012
    Date of Patent: November 12, 2013
    Assignees: Daewoong Pharmaceutical Co., Ltd., Medifron DBT Co., Ltd.
    Inventors: Dong Wook Kang, Jee Woo Lee, Young Ho Kim, Hee Kim, Hee Jin Ha, Eun Joo Nam, Chan Mi Joung
  • Patent number: 8507553
    Abstract: The present invention relates to the novel benzofuran derivatives, the preparation thereof and the composition comprising the same. The benzofuran derivatives of the present invention showed potent inhibiting activity of beta-amyloid aggregation and cell cytotoxicity resulting in stimulating the proliferation of neuronal cells as well as recovering activity of memory learning injury caused by neuronal cell injury using transformed animal model with beta-amyloid precursor gene, therefore the compounds can be useful in treating or preventing cognitive function disorder.
    Type: Grant
    Filed: June 5, 2012
    Date of Patent: August 13, 2013
    Assignees: Daewoong Pharmaceutical Co., Ltd., Medifron DBT Co., Ltd.
    Inventors: Dong Wook Kang, Jee Woo Lee, Young Ho Kim, Hee Kim, Hee Jin Ha, Eun Joo Nam, Chan Mi Joung
  • Patent number: 8455542
    Abstract: The present invention relates to the novel benzofuran derivatives, the preparation thereof and the composition comprising the same. The benzofuran derivatives of the present invention showed potent inhibiting activity of beta-amyloid aggregation and cell cytotoxicity resulting in stimulating the proliferation of neuronal cells as well as recovering activity of memory learning injury caused by neuronal cell injury using transformed animal model with beta-amyloid precursor gene, therefore the compounds can be useful in treating or preventing cognitive function disorder.
    Type: Grant
    Filed: June 5, 2012
    Date of Patent: June 4, 2013
    Assignees: Daewoong Pharmaceutical Co., Ltd., Medifron DBT Co., Ltd.
    Inventors: Dong Wook Kang, Jee Woo Lee, Young Ho Kim, Hee Kim, Hee Jin Ha, Eun Joo Nam, Chan Mi Joung
  • Publication number: 20120259006
    Abstract: The present invention relates to the novel benzofuran derivatives, the preparation thereof and the composition comprising the same. The benzofuran derivatives of the present invention showed potent inhibiting activity of beta-amyloid aggregation and cell cytotoxicity resulting in stimulating the proliferation of neuronal cells as well as recovering activity of memory learning injury caused by neuronal cell injury using transformed animal model with beta-amyloid precursor gene, therefore the compounds can be useful in treating or preventing cognitive function disorder.
    Type: Application
    Filed: June 5, 2012
    Publication date: October 11, 2012
    Applicants: DAEWOONG PHARMACEUTICAL CO., LTD, MEDIFRON DBT CO., LTD.
    Inventors: Dong Wook KANG, Jee Woo LEE, Young Ho KIM, Hee KIM, Hee Jin HA, Eun Joo NAM, Chan Mi JOUNG
  • Publication number: 20120245165
    Abstract: The present invention relates to the novel benzofuran derivatives, the preparation thereof and the composition comprising the same. The benzofuran derivatives of the present invention showed potent inhibiting activity of beta-amyloid aggregation and cell cytotoxicity resulting in stimulating the proliferation of neuronal cells as well as recovering activity of memory learning injury caused by neuronal cell injury using transformed animal model with beta-amyloid precursor gene, therefore the compounds can be useful in treating or preventing cognitive function disorder.
    Type: Application
    Filed: June 5, 2012
    Publication date: September 27, 2012
    Applicants: DAEWOONG PHARMACEUTICAL CO., LTD, MEDIFRON DBT CO., LTD.
    Inventors: Dong Wook KANG, Jee Woo LEE, Young Ho KIM, Hee KIM, Hee Jin HA, Eun Joo NAM, Chan Mi JOUNG
  • Publication number: 20120245225
    Abstract: The present invention relates to the novel benzofuran derivatives, the preparation thereof and the composition comprising the same. The benzofuran derivatives of the present invention showed potent inhibiting activity of beta-amyloid aggregation and cell cytotoxicity resulting in stimulating the proliferation of neuronal cells as well as recovering activity of memory learning injury caused by neuronal cell injury using transformed animal model with beta-amyloid precursor gene, therefore the compounds can be useful in treating or preventing cognitive function disorder.
    Type: Application
    Filed: June 5, 2012
    Publication date: September 27, 2012
    Applicants: DAEWOONG PHARMACEUTICAL CO., LTD, MEDIFRON DBT CO., LTD.
    Inventors: Dong Wook KANG, Jee Woo LEE, Young Ho KIM, Hee KIM, Hee Jin HA, Eun Joo NAM, Chan Mi JOUNG
  • Patent number: 8263649
    Abstract: The present invention relates to the novel benzofuran derivatives, the preparation thereof and the composition comprising the same. The benzofuran derivatives of the present invention showed potent inhibiting activity of beta-amyloid aggregation and cell cytotoxicity resulting in stimulating the proliferation of neuronal cells as well as recovering activity of memory learning injury caused by neuronal cell injury using transformed animal model with beta-amyloid precursor gene, therefore the compounds can be useful in treating or preventing cognitive function disorder.
    Type: Grant
    Filed: October 2, 2007
    Date of Patent: September 11, 2012
    Assignee: Medifron DBT Co., Ltd.
    Inventors: Dong Wook Kang, Jee Woo Lee, Young Ho Kim, Hee Kim, Hee Jin Ha, Eun Joo Nam, Chan Mi Joung
  • Publication number: 20100197685
    Abstract: The present invention relates to the novel benzofuran derivatives, the preparation thereof and the composition comprising the same. The benzofuran derivatives of the present invention showed potent inhibiting activity of beta-amyloid aggregation and cell cytotoxicity resulting in stimulating the proliferation of neuronal cells as well as recovering activity of memory learning injury caused by neuronal cell injury using transformed animal model with beta-amyloid precursor gene, therefore the compounds can be useful in treating or preventing cognitive function disorder.
    Type: Application
    Filed: October 2, 2007
    Publication date: August 5, 2010
    Applicants: DIGITAL BIOTECH CO., LTD, DAEWOONG PHARMACEUTICAL CO., LTD
    Inventors: Dong Wook Kang, Jee Woo Lee, Young Ho Kim, Hee Kim, Hee Jin Ha, Eun Joo Nam, Chan Mi Joung