Abstract: Proposed is a method for guiding at least two detailed performance experiments. The method may include providing a data input screen for at least one requirement item selected among items for experimentation to be used in performing each detailed performance experiment on an oligonucleotide for detecting the target nucleic acid molecule. The method may also include displaying preparation information for a reaction plate for performing, by a nucleic acid detection device, an amplification reaction using the oligonucleotide on the basis of the data input. The method may further include receiving result data of the amplification reaction by using an amplification composition containing the oligonucleotide, on the basis of the preparation information.

Abstract: According to an embodiment of the present invention, there is provided a method method for providing a user interface on a user interface-providing device for operating a liquid handler to prepare a candidate composition to be tested to provide a nucleic acid amplification composition for detecting a target nucleic acid molecule, the method comprising: displaying an input screen for selecting types of tasks and a plurality of test items for preparing the candidate composition: displaying (i) a parameter defined by the selected task and the test item and (ii) an input screen for receiving the parameter value for the displayed parameter; receiving the parameter value; and transferring the received parameter value to the liquid handler, wherein the user interface-providing device communicates with the liquid handler such that the liquid handler is operated at least partially based on an instruction and a parameter value to be referenced upon execution of the instruction, wherein the test of the candidate composi

Abstract: A computer-implemented method for generating a technical construction file for a reagent for detecting a target nucleic acid molecule according to one embodiment, includes: providing an input screen for items common to at least two or more detailed performance experiments among a plurality of detailed performance experiments for the reagent for detecting the target nucleic acid molecule, wherein the technical construction file includes two or more detailed performance documents including the at least two or more detailed performance experiments; receiving input of contents for the common items at once; and exporting the common items and the received contents for the common items to the two or more detailed performance documents to generate the two or more detailed performance documents.

Abstract: A method for preparing pluripotent stem cell-derived hematopoietic stem cells and a method of constructing a humanized mouse model with the prepared hematopoietic stem cells. The method of preparing the hematopoietic stem cells identified an optimal differentiation condition according to a combination of low-molecular-weight compounds and protein growth factors without gene insertion, and thus may differentiate hematopoietic stem cells from pluripotent stem cells at high yield.

Abstract: The present invention provides a method for detecting mycoplasma, which can directly confirm whether a cell is infected with mycoplasma, by simultaneously amplifying DNA extracted from lysing a host cell infected with mycoplasma, and mitochondrial DNA in the cytoplasm of the host cell. According to the method of the present invention, by directly using the DNA inside the host cell, the DNA of mycoplasma bound around the nucleus of the host cell can be used as an amplification target, thereby increasing detection sensitivity. In addition, since the mitochondrial DNA inside the host cell is used as an amplification target of an internal control sample, whether the sample has been sampled in an appropriate amount can be confirmed in a convenient manner, and furthermore, by comparing the band size between the internal control sample and the mycoplasma DNA, the degree of mycoplasma infection can be quantitatively confirmed.

Abstract: An apparatus for fabricating a microneedle includes a first substrate having a plurality of first spaced viscous materials formed on one side thereof and including at least one first transmission area, a second substrate disposed opposite to the first substrate, having a plurality of second spaced viscous materials formed on one side thereof facing the first substrate and including at least one second transmission area corresponding to the first transmission area, a light emitting unit arranged to correspond to the first transmission area on the other side of the first substrate and emitting light, and a light receiving unit arranged to correspond to the second transmission area on the other side of the second substrate. The microneedle manufacturing apparatus checks whether the first substrate and the second substrate are aligned according to whether the light receiving unit receives light emitted from the light emitting unit.

Abstract: The present invention provides a method for detecting mycoplasma, which can directly confirm whether a cell is infected with mycoplasma, by simultaneously amplifying DNA extracted from lysing a host cell infected with mycoplasma, and mitochondrial DNA in the cytoplasm of the host cell. According to the method of the present invention, by directly using the DNA inside the host cell, the DNA of mycoplasma bound around the nucleus of the host cell can be used as an amplification target, thereby increasing detection sensitivity. In addition, since the mitochondrial DNA inside the host cell is used as an amplification target of an internal control sample, whether the sample has been sampled in an appropriate amount can be confirmed in a convenient manner, and furthermore, by comparing the band size between the internal control sample and the mycoplasma DNA, the degree of mycoplasma infection can be quantitatively confirmed.

Abstract: Disclosed is a sealed structure for an electrochemical device having a hollow space therein, further comprising a material generating gases via thermal decomposition in the hollow space. Also, disclosed is an electrochemical device comprising a cathode, an anode, a separator, an electrolyte, a casing for the device, and the structure for the electrochemical device.

Abstract: Disclosed is a sealed structure for an electrochemical device having a hollow space therein, further comprising a material generating gases via thermal decomposition in the hollow space. Also, disclosed is an electrochemical device comprising a cathode, an anode, a separator, an electrolyte, a casing for the device, and the structure for the electrochemical device.

Abstract: Disclosed is a sealed structure for an electrochemical device having a hollow space therein, further comprising a material generating gases via thermal decomposition in the hollow space. Also, disclosed is an electrochemical device comprising a cathode, an anode, a separator, an electrolyte, a casing for the device, and the structure for the electrochemical device.

Abstract: Provided is a secondary battery electrolyte having improved high temperature properties and overcharge-prevention properties, particularly improved overcharge-prevention properties under high voltage/high current conditions, in conjunction with a minimized deterioration of the battery performance, by adding 3 to 5% by weight of cyclohexyl benzene (CHB) and 0.2 to 1.5% by weight of 2-fluoro biphenyl (2-FBP) as overcharge-preventing additives to an electrolyte of a lithium secondary battery.

Abstract: Disclosed is an interferon-? (IFN-?) fused protein having IFN-? fused to a cytoplasmic transduction peptide (CTP). The disclosure relates to a fused protein wherein a CTP, which binds well to cell-membrane barriers and enables translocation into the liver, is genetically fused to a human IFN-?, thereby enhancing the conjugation capacity of cell membranes and antiviral activity, inhibiting CTP transport into the cell nucleus, and enhancing the translocation and settlement of the fused protein into the liver and of transduction to the liver tissue. Accordingly, it is possible to develop protein-based medicines effective for preventing or treating various liver diseases associated with viral infection at low doses.

Abstract: Provided is a lithium secondary battery comprising a lithium transition metal compound-containing cathode and a graphitized carbon-containing anode with addition of a surfactant to the cathode and/or the anode, whereby the addition of the surfactant improves the wettability of an electrolyte on the electrode, thereby increasing the battery capacity and improving rate properties and cycle properties of the battery, in conjunction with a significant reduction of a manufacturing process time of the battery.

Abstract: Disclosed is the structure of a center pin assembly inserted into the winding center of a winding-type electrode assembly of an electrochemical device, which has a case containing the winding-type electrode assembly. The center pin assembly can secure the safety of an electrochemical device when physical impact (e.g. squeezing, shock) is applied from the outside, when the internal temperature rises, and/or when the device is overcharged. The center pin assembly includes a center pin manufactured by winding a planar substrate into a tubular shape, the planar substrate having at least two protrusions formed in an embossing type or at least two discontinuous scores formed in a predetermined shape; and a container placed in a space inside the center pin, the container containing a substance capable of improving the safety of the device.

Abstract: Provided is a secondary battery electrolyte having improved high temperature properties and overcharge-prevention properties, particularly improved overcharge-prevention properties under high voltage/high current conditions, in conjunction with a minimized deterioration of the battery performance, by adding 3 to 5% 100 by weight of cyclohexyl benzene (CHB) and 0.2 to 1.5% by weight of 2-fluoro biphenyl (2-FBP) as overcharge-preventing additives to an electrolyte of a lithium secondary battery.

Abstract: Disclosed is an electrochemical device including a gas discharge member disposed in inner volumes thereof or used as an element for forming the device, wherein the gas discharge member comprises: (a) a core portion containing a compound that discharges gases other than oxygen at a predetermined temperature range; and (b) a polymeric shell portion for encapsulating the compound and surrounding the core portion. A center pin for an electrochemical device having the gas discharge member inserted into the interstitial volumes of the device is also disclosed. The electrochemical device comprising the gas discharge member, which discharges a large amount of gas at a predetermined temperature and is inserted into the inner volumes of the device, is prevented from ignition or explosion under overcharge and high-temperature storage conditions with no drop in the performance.

Abstract: Disclosed is a sealed structure for an electrochemical device having a hollow space therein, further comprising a material generating gases via thermal decomposition in the hollow space. Also, disclosed is an electrochemical device comprising a cathode, an anode, a separator, an electrolyte, a casing for the device, and the structure for the electrochemical device.

Abstract: Disclosed are nonaqueous electrolyte additives, which can improve the safety of a battery upon overcharge of the battery without reducing the performance of the battery, as well as a nonaqueous electrolyte comprising the additives, and a lithium secondary battery comprising the nonaqueous electrolyte. More particularly, disclosed are a nonaqueous electrolyte comprising both fluorobiphenyl and fluorotoluene as additives, and a lithium secondary battery comprising the nonaqueous electrolyte.

Abstract: Disclosed is the structure of a center pin assembly inserted into the winding center of a winding-type electrode assembly of an electrochemical device, which has a case containing the winding-type electrode assembly. The center pin assembly can secure the safety of an electrochemical device when physical impact (e.g. squeezing, shock) is applied from the outside, when the internal temperature rises, and/or when the device is overcharged. The center pin assembly includes a center pin manufactured by winding a planar substrate into a tubular shape, the planar substrate having at least two protrusions formed in an embossing type or at least two discontinuous scores formed in a predetermined shape; and a container placed in a space inside the center pin, the container containing a substance capable of improving the safety of the device.

Abstract: Provided is a lithium secondary battery comprising a lithium transition metal compound-containing cathode and a graphitized carbon-containing anode with addition of a surfactant to the cathode and/or the anode, whereby the addition of the surfactant improves the wettability of an electrolyte on the electrode, thereby increasing the battery capacity and improving rate properties and cycle properties of the battery, in conjunction with a significant reduction of a manufacturing process time of the battery.