Patents by Inventor Eun Ju Sohn

Eun Ju Sohn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12357686
    Abstract: The present invention relates to: a porcine epidemic diarrhea (PED) virus protein comprising an amino acid sequence represented by SEQ ID NO:5; a vaccine composition comprising same; and the like.
    Type: Grant
    Filed: April 13, 2020
    Date of Patent: July 15, 2025
    Assignee: BIOAPPLICATIONS INC.
    Inventors: Eun-Ju Sohn, Yong Jik Lee
  • Patent number: 12234262
    Abstract: The present invention relates to a vaccinia virus recombinant A33R protein and a kit for diagnosing antibodies against orthopoxvirus containing the same, and more particularly, to a recombinant A33R protein in which the transmembrane domain of the vaccinia virus A33R protein is replaced with a peptide linker, a recombinant vector for efficiently expressing the recombinant A33R protein, a transgenic organism, a method for producing the recombinant A33R protein, a composition and kit for diagnosing antibodies against orthopoxvirus containing the recombinant A33R protein.
    Type: Grant
    Filed: December 21, 2023
    Date of Patent: February 25, 2025
    Assignee: REPUBLIC OF KOREA (DEFENSE ACQUISITION PROGRAM ADMINISTRATION)
    Inventors: Eun-Ju Sohn, Hyangju Kang, So Yun Park
  • Patent number: 12156907
    Abstract: The present invention relates to a technique of preparing a vaccine composition from PCV2 isolated from a plant transformed with a chlorophyll-targeting recombinant vector for expression in plants and provides a recombinant vector carrying a polynucleotide coding for a recombinant protein in which a chlorophyll-targeting protein and a PCV2 capsid protein are fused to each other. In addition, provided are a transgenic plant transformed with the recombinant vector, a method for isolating and purifying a target protein from the transgenic plant, a method for preparing a vaccine composition containing virus-like particles by using same, and a vaccine composition prepared by the preparation method.
    Type: Grant
    Filed: May 14, 2021
    Date of Patent: December 3, 2024
    Assignee: BIOAPPLICATIONS INC.
    Inventors: Eun-Ju Sohn, Yongjik Lee, Sangmin Lee
  • Publication number: 20240350614
    Abstract: The present invention relates to: a recombinant vector comprising a nucleotide sequence of antigen protein(s) Lectin, CD2v, p72, p54, p30, p15, p35, E199L, and/or F317L of an African swine fever virus; a transformant transformed by means of the recombinant vector; and a vaccine composition for preventing African swine fever, comprising, as an active ingredient, African swine fever virus antigen protein(s) Lectin, CD2v, p72, p54, p30, p15, p35, E199L, and/or F317L, isolated from the transformant; and the like.
    Type: Application
    Filed: August 12, 2022
    Publication date: October 24, 2024
    Applicant: BioApplications Inc.
    Inventors: Hyangju KANG, Bo-Hwa CHOI, Eun-Ju SOHN
  • Publication number: 20240316184
    Abstract: The present invention relates to a plant-based COVID-19 variant recombinant spike protein expression vector, and a recombinant protein using the expression vector, wherein a plant expression system is used such that the recombinant protein does not have the disadvantages of animal-derived recombinant proteins and exhibits an excellent SARS coronavirus 2 prevention and treatment effect, and thus can be effectively utilized as a safe composition for preventing and treating COVID-19.
    Type: Application
    Filed: July 19, 2022
    Publication date: September 26, 2024
    Applicant: BioApplications Inc.
    Inventors: Eun-Ju SOHN, Bo-Hwa CHOI, Hyangju KANG, Kyungmin MIN, Minhee PARK, Nam Hyung KIM, Daniel KIM, Yoo-Kyoung LEE, Byung-Chul KIM, Heeji LIM, Sundong JANG, Kwangwook KIM, Soo Ji KIM, Dokeun KIM, You-Jin KIM, Jung-Ah LEE, Woo-Jung PARK
  • Publication number: 20230293665
    Abstract: The present invention relates to a vaccine composition including, as active ingredients, a recombinant Zika virus envelope protein including an amino acid sequence of SEQ ID NO: 1, and an adjuvant selected from alum, monophosphoryl lipid A (MPL), or a combination thereof, a recombinant vector for producing the recombinant Zika virus envelope protein in a plant, a transformant transformed with the vector, and a method for producing the recombinant Zika virus envelope protein.
    Type: Application
    Filed: August 11, 2021
    Publication date: September 21, 2023
    Inventors: Tae-Wook Hahn, Minna Shin, Eun-Ju Sohn, Hyangju Kang
  • Publication number: 20230287440
    Abstract: The present invention relates to a recombinant vector including a polynucleotide encoding an African swine fever virus P32 protein, a transgenic organism transformed with the recombinant vector, a composition and kit for diagnosing African swine fever comprising an African swine fever virus P32 antigen protein isolated from the transgenic organism, and the like.
    Type: Application
    Filed: June 16, 2020
    Publication date: September 14, 2023
    Inventors: Eun-Ju SOHN, Sangmin LEE, Hyang Ju KANG
  • Publication number: 20230218729
    Abstract: The present invention relates to a vaccine composition which is form neutering or spaying an animal and comprises a recombinant protein in which cholera toxin B subunit (CTB) and gonadotropin-releasing hormone (GnRH) are fused. More specifically, provided are: a recombinant protein for neutering or spaying an animal and for inducing antibodies against GnRH; a recombinant vector for producing the recombinant protein; a vaccine composition for neutering or spaying an animal, the vaccine composition comprising the recombinant protein; and a method for neutering or spaying an animal by using the vaccine composition. The vaccine composition according to the present invention induces antibodies against GnRH in an individual, thereby atrophying the ovaries or testes thereof. Therefore, the present invention can, at low cost, a high level of safety, and with minimal side effects, replace surgical procedures for neutering and spaying, and be beneficially used to neuter or spay an animal.
    Type: Application
    Filed: March 12, 2021
    Publication date: July 13, 2023
    Inventors: Eun-Ju SOHN, Yong Jik LEE
  • Publication number: 20230203101
    Abstract: The present invention relates to a recombinant spike protein of the COVID-19 virus forming a trimer and a method for mass-producing the recombinant spike protein, and more specifically to a method for designing a recombinant gene expressing a recombinant spike protein of the COVID-19 virus forming a trimer for the purposes of enhancing immunogenicity and effective antigen delivery, and a method for mass-producing the recombinant spike protein in plants.
    Type: Application
    Filed: April 22, 2021
    Publication date: June 29, 2023
    Applicants: POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION, KOREA NATIONAL INSTITUTE OF HEALTH, BIOAPPLICATIONS INC
    Inventors: In Hwan HWANG, Shijian SONG, Rezaul Islam Khan MD, Haiping DIAO, Eun Ju SOHN, Bo Hwa CHOI, Jang Hoon CHOI, Eun Young JANG, Young Jae LEE
  • Publication number: 20230173044
    Abstract: The present invention relates to a vaccine composition for removing boar taint, the vaccine composition including a recombinant protein in which a cholera toxin B subunit (CTB) and n gonadotropin-releasing hormones (GnRH) are fused, and more specifically, provides a recombinant protein for removing boar taint to induce antibodies against GnRH, a recombinant vector for producing the same, a vaccine composition for removing boar taint, the vaccine composition including the recombinant protein, and a method for removing boar taint using the same. The vaccine composition according to the present invention induces antibodies against GnRH in an individual and has the effect of atrophying the testes through the induction of antibodies. Therefore, the present invention can be usefully used to remove boar taint by immunologically castrating a boar at low cost and with high safety and minimal side effects.
    Type: Application
    Filed: June 29, 2020
    Publication date: June 8, 2023
    Inventors: Eun-Ju SOHN, Yong Jik LEE, Sangmin LEE
  • Publication number: 20220133879
    Abstract: The present invention relates to: a porcine epidemic diarrhea (PED) virus protein comprising an amino acid sequence represented by SEQ ID NO:5; a vaccine composition comprising same; and the like.
    Type: Application
    Filed: April 13, 2020
    Publication date: May 5, 2022
    Inventors: Eun-Ju Sohn, Yong Jik Lee
  • Publication number: 20220088167
    Abstract: The present invention relates to a vaccine composition for preventing tuberculosis comprising a glycosylated Ag85A protein, a vector for preparing the protein, a transformant using the vector, and a method for producing the glycosylated Ag85A protein by using the transformant. A vaccine composition comprising a glycosylated Ag85A protein of the present invention has the effect of inducing an increase in multifunctional T cells simultaneously secreting IFN-?, TNF-?, and IL-2 which are important in regard to a protective effect against tuberculosis, and thus can be usefully used as a vaccine for preventing tuberculosis. Furthermore, the glycosylated Ag85A protein can be effectively expressed in plants and separated with high yield by means of a vector optimized for protein production, and thus can be mass produced at low cost.
    Type: Application
    Filed: January 23, 2020
    Publication date: March 24, 2022
    Inventors: Yong Jik Lee, Eun-Ju Sohn, Sung Jae Shin, Hongmin Kim, KwanGoo Cho, Myung Ryurl OH
  • Publication number: 20210330780
    Abstract: The present invention relates to a technique of preparing a vaccine composition from PCV2 isolated from a plant transformed with a chlorophyll-targeting recombinant vector for expression in plants and provides a recombinant vector carrying a polynucleotide coding for a recombinant protein in which a chlorophyll-targeting protein and a PCV2 capsid protein are fused to each other. In addition, provided are a transgenic plant transformed with the recombinant vector, a method for isolating and purifying a target protein from the transgenic plant, a method for preparing a vaccine composition containing virus-like particles by using same, and a vaccine composition prepared by the preparation method.
    Type: Application
    Filed: May 14, 2021
    Publication date: October 28, 2021
    Inventors: Eun-Ju Sohn, Yongjik Lee, Sangmin Lee
  • Patent number: 10934558
    Abstract: The present invention relates to a recombinant vector carrying cellulose-binding domain 3 and a method for separating a target protein using the recombinant vector. The protein isolating method of the present invention can easily separate a fusion protein containing a target protein by using the recombinant vector to bind a transformed plant body to cellulose and can effectively isolate the target protein from a cellulose-binding domain by treating the fusion protein with enterokinase, thus being expected to find industrial applications in various fields.
    Type: Grant
    Filed: May 10, 2018
    Date of Patent: March 2, 2021
    Inventors: Inhwan Hwang, Eun Ju Sohn, Yongjik Lee
  • Publication number: 20200270624
    Abstract: The present invention relates to a recombinant vector carrying cellulose-binding domain 3 and a method for separating a target protein using the recombinant vector. The protein isolating method of the present invention can easily separate a fusion protein containing a target protein by using the recombinant vector to bind a transformed plant body to cellulose and can effectively isolate the target protein from a cellulose-binding domain by treating the fusion protein with enterokinase, thus being expected to find industrial applications in various fields.
    Type: Application
    Filed: May 10, 2018
    Publication date: August 27, 2020
    Inventors: Inhwan Hwang, Eun Ju Sohn, Yongjik Lee
  • Patent number: 10344293
    Abstract: A recombinant vector for transforming a plant, a plant transformed with the recombinant vector, a plant-made classical swine fever virus antigen pmE2 protein expressed in the plant and uses thereof is provided. By using a recombinant vector having a polynucleotide encoding a GP55 protein of CSFV according to the present invention; and a polynucleotide encoding a cellulose-binding domain protein; and a plant transformed with the recombinant vector, a plant-made classical swine fever virus antigen pmE2 protein may be produced with high efficiency, and has higher safety and stability than those achieved by other production methods. Also, since the plant-derived classical swine fever virus antigen protein pmE2 has a cellulose-binding domain (CBD) protein, it may be usefully used as an effective marker to determine a virus exposure pathway and an antibody producing pathway.
    Type: Grant
    Filed: May 12, 2016
    Date of Patent: July 9, 2019
    Assignees: BIO APPLICATIONS INC., REPUBLIC OF KOREA (ANIMAL AND PLANT QUARANTINE AGENCY)
    Inventors: Dong Jun An, Seong In Lim, Jae Young Song, Hye Young Jeoung, Eun Ju Sohn, In Hwan Hwang, Nam Jo Park, Yong Jik Lee, Nam Hyung Kim, Sung Min Gu
  • Patent number: 10239928
    Abstract: The present invention provides a plant expressing a target protein, a method of preparing the same and a method of preparing a composition for oral administration of a biopharmaceutical using the same. A target protein expression system using plant cells according to the present invention solves conventional problems in plant cell culture, provides a method of producing a large quantity of target proteins including a biopharmaceutical protein and allowing a target protein to have a resistance to a protease present in a digestive organ, and therefore is very effective to enable commercialization of plant-derived biopharmaceuticals.
    Type: Grant
    Filed: May 17, 2017
    Date of Patent: March 26, 2019
    Assignee: POSTECH ACADEMY-INDUSTRY FOUNDATION
    Inventors: Inhwan Hwang, Hyang Ju Kang, Eun Ju Sohn, Yong Jik Lee, Per-Olof Berggren, Yun Joo Yoo, Jae Yoon Kim
  • Publication number: 20180305710
    Abstract: A recombinant vector for transforming a plant, a plant transformed with the recombinant vector, a plant-made classical swine fever virus antigen pmE2 protein expressed in the plant and uses thereof is provided. By using a recombinant vector having a polynucleotide encoding a GP55 protein of CSFV according to the present invention; and a polynucleotide encoding a cellulose-binding domain protein; and a plant transformed with the recombinant vector, a plant-made classical swine fever virus antigen pmE2 protein may be produced with high efficiency, and has higher safety and stability than those achieved by other production methods. Also, since the plant-derived classical swine fever virus antigen protein pmE2 has a cellulose-binding domain (CBD) protein, it may be usefully used as an effective marker to determine a virus exposure pathway and an antibody producing pathway.
    Type: Application
    Filed: May 12, 2016
    Publication date: October 25, 2018
    Applicants: BIOAPPLICATIONS INC., REPUBLIC OF KOREA (ANIMAL AND PLANT QUARANTINE AGENCY)
    Inventors: Dong Jun AN, Seong In LIM, Jae Young SONG, Hye Young JEOUNG, Eun Ju SOHN, In Hwan HWANG, Nam Jo PARK, Yong Jik LEE, Nam Hyung KIM, Sung Min GU
  • Publication number: 20170335361
    Abstract: The present invention provides a plant expressing a target protein, a method of preparing the same and a method of preparing a composition for oral administration of a biopharmaceutical using the same. A target protein expression system using plant cells according to the present invention solves conventional problems in plant cell culture, provides a method of producing a large quantity of target proteins including a biopharmaceutical protein and allowing a target protein to have a resistance to a protease present in a digestive organ, and therefore is very effective to enable commercialization of plant-derived biopharmaceuticals.
    Type: Application
    Filed: May 17, 2017
    Publication date: November 23, 2017
    Inventors: Inhwan HWANG, Hyang Ju KANG, Eun Ju SOHN, Yong Jik LEE, Per-Olof Berggren, Yun Joo YOO, Jae Yoon KIM
  • Patent number: 9512173
    Abstract: The present invention relates to a method of isolating a protein containing a cellulose binding domain from plants using various structures of cellulose and/or variants thereof. According to the method of isolating a protein, as a high affinity cellulose binding domain is used, a high purity recombinant protein is rapidly and effectively isolated in large quantities at low cost, and thus can be applied in various industrial fields.
    Type: Grant
    Filed: September 25, 2013
    Date of Patent: December 6, 2016
    Assignee: BIOAPPLICATIONS INC.
    Inventors: Inhwan Hwang, Soo Hong Park, Yong Jik Lee, Eun Ju Sohn, Kyung Min Min