Abstract: Devices, systems, compositions and methods for long term or prolonged transdermal administration of an active agent are provided.

Abstract: Devices, systems, compositions and methods for long term or prolonged transdermal administration of an active agent are provided.

Abstract: Methods, compositions, and devices for transdermally administering an active agent such as donepezil are provided. In one aspect, the method comprises contacting skin with a transdermal device designed to create a depot of the active agent in the subject, removing the transdermal device and continuing to administer the active agent for a period after the device is removed.

Abstract: A method of measuring the height of a foot arch precisely and easily using two essential heights of the foot arch is disclosed. In the method, a foot cast is primarily cast by pouring plaster into a foot mold. Thereafter, a first intersecting point and a second intersecting point are determined. The first intersecting point is determined by making a first line and a third line intersect. The second intersecting point is determined by making a second line and the third line intersect. The first line is a straight line extending from the center of the second toe to the center of the heel end. The second line is a straight line extending from the center of the big toe to a point spaced apart inwardly from the center of the heel end by ⅛ of the total distance of the heel end. The third line is a center line of the transverse arch of the foot. Finally, a first height and a second height are measured while the foot pattern is set in an upright position.

Abstract: A method for recovering a recombinant protein from a protein solution containing high molecular weight contaminating proteins by directly adding Group IIA metal salts to the solution in amounts sufficient to selectively precipitate the high molecular weight protein contaminants is disclosed.The high molecular weight precipitates are removed and the solution is further processed to remove low molecular weight contaminating proteins and other non-protein contaminants. The recombinant protein is subsequently recovered and further processed to produce a protein composition suitable for its intended use.

Abstract: A method for recovering a recombinant protein from a protein solution containing high molecular weight contaminating proteins by directly adding Group IIA metal salts to the solution in amounts sufficient to selectively precipitate the high molecular weight protein contaminants is disclosed.The high molecular weight precipitates are removed and the solution is further processed to remove low molecular weight contaminating proteins and other non-protein contaminants. The recombinant protein is subsequently recovered and further processed to produce a protein composition suitable for its intended use.