Abstract: One aspect of the disclosure relates to a cargo delivery system comprising an autophagy targeting ligand and a target-binding ligand. In one aspect of the disclosure, by comprising an autophagy targeting ligand, cargo, which is a target-binding ligand that specifically binds to a target, is delivered to the p62 protein and autophagy is activated, so that depending on the type of target-binding ligand used, a target to be degraded can be selectively and directly removed. Accordingly, the cargo delivery system according to an aspect of the disclosure may be used in pharmaceutical compositions or food compositions for preventing, alimerating, and treating various diseases.

Abstract: The present invention discloses a MXene surface-modified with a metal alkoxide, which is formed by surface-modifying a MXene represented by the following Chemical Formula 1 with a metal alkoxide, in which the metal alkoxide is covalently bonded to the surface of the MXene and is present as a ligand. Mn+1 Xn??[Chemical Formula 1] Here, M is one or more transition metal elements selected from the group consisting of Sc, Ti, V, Cr, Mn, Y, Zr, Nb, Mo, Hf, and Ta, X is at least one of carbon and nitrogen, and n is an integer from 1 to 4.

Abstract: A semiconductor device includes a substrate including an N-type region and a P-type region, a first active pattern on the N-type region, a first gate structure on the N-type region, the first gate structure crossing the first active pattern and including fluorine (F), a second active pattern on the P-type region, and a second gate structure on the P-type region, the second gate structure crossing the second active pattern and including fluorine (F), where the first gate structure includes a first gate dielectric film on the first active pattern, and a first gate electrode on the first gate dielectric film, the second gate structure includes a second gate dielectric film on the second active pattern and a second gate electrode on the second gate dielectric film, and a fluorine (F) concentration of the second gate dielectric film is smaller than a fluorine (F) concentration of the first gate dielectric film.

Abstract: A display device includes a display panel; a metal plate and a filling member which are disposed on a lower surface of the display panel, are disposed on the same layer, and include different materials; and a fingerprint sensor which is disposed on a lower surface of the filling member and is overlapped by the filling member in a thickness direction, wherein the metal plate includes a plurality of outlines extending in different directions in plan view, one outline of the metal plate includes a plurality of sides extending along a first direction and a discontinuous part disposed between the sides, an open part recessed from the discontinuous part in a second direction intersecting the first direction is formed in the metal plate, and the filling member is located in the open part in plan view.

Abstract: A multilayer electronic component includes a body including a dielectric layer and first and second internal electrodes alternately disposed with the dielectric layer therebetween, and including first and second surfaces opposing each other in a first direction, third and fourth surfaces opposing each other in a second direction, and fifth and sixth surfaces opposing each other in a third direction; and an external electrode including a connection portion disposed on the third or fourth surface and a band portion extending from the connection portion to portions of the first and second surfaces, wherein the external electrode includes a sputtered layer disposed in the connection portion and contacting the first or second internal electrode and including Cu, an oxide layer disposed on the sputtered layer and including a Cu oxide, and a conductive polymer layer disposed in the band portion and including a polymer material.

Abstract: A battery managing apparatus according to an embodiment of the present disclosure includes a measurement unit configured to measure the voltage of a battery that is charged by repeating a charging period and a resting period; and a control unit configured to calculate a resistance corresponding to each of a plurality of resting periods, generate a first profile indicating a correspondence relationship between a state of charge (SOC) and the resistance of the battery, divide an SOC section of the first profile into a plurality of unit sections, and calculate a summed resistance of the battery based on a weight and a reference resistance corresponding to each of the plurality of unit sections.

Abstract: A reflectivity correction method using a double polarization variable-based bright band detection result includes a preprocessing operation for correcting a double polarization variable observation error and calculating a depolarization ratio; a fuzzy classifier generation operation for calculating a weighting and a membership function of each characteristic variable using a bright band height extracted from a quasi-vertical profile generated from specific elevation angle data, a bright band detection operation for detecting a bright band using a depolarization ratio and a fuzzy classifier for each elevation angle, and a reflectivity correction operation for correcting reflectivity over-observation for a detected bright band region on the basis of a correction factor calculated using an apparent profile of reflectivity generated by averaging reflectivity data for the bright band region for each elevation angle.

Abstract: A novel multi-fused-ring compound and a composition for preventing or treating multiple myeloma comprising the same as an active ingredient is described herein. The compound is a derivative synthesized from the natural compound ginsenoside as a starting material, and shows no cytotoxicity to normal hematopoietic stem cells, while exhibiting a significant killing effect on various multiple myeloma cell lines, indicating that it may be administered for a long period of time without side effects. In addition, the compound exhibits a significant synergistic effect when co-administered with the immunomodulator thalidomide or its analog lenalidomide, and thus may be useful as an efficient therapeutic agent or therapeutic aid agent composition for multiple myeloma, an incurable disease.

Abstract: In an apparatus for controlling a driving system of a hybrid vehicle and a driving system control method thereof, the torque of an internal combustion driving system and the torque of an electric driving system in the hybrid vehicle are controlled according to the states of the internal combustion driving system and the electric driving system, so that the states of the driving systems in the hybrid vehicle may be maintained in balance, raising a residual value of the vehicle.

Abstract: A storage device comprises first and second storage devices mounted on respective first and second PCBs (Printed Circuit Boards) that are separated from each other, the first and second PCBs configured to store different data. The first storage device includes a first storage controller, and a first shock sensor that senses an impact of the first storage device to output a first sensor signal. The second storage device includes a second shock sensor different from the first shock sensor, and senses an impact of the second storage device to output a second sensor signal. The first storage controller outputs a first internal control signal that controls an internal operation of the first storage device based on the first sensor signal. The first storage device and the second storage device transmit data to each other based on the first sensor signal and the second sensor signal.

Abstract: Disclosed are semiconductor packages and/or methods of fabricating the same. The semiconductor package comprises a package substrate, a first semiconductor chip mounted on the package substrate, a second semiconductor chip mounted on a top surface of the first semiconductor chip, and a first under-fill layer that fills a space between the package substrate and the first semiconductor chip. The package substrate includes a cavity in the package substrate, and a first vent hole that extends from a top surface of the package substrate and is in fluid communication with the cavity. The first under-fill layer extends along the first vent hole to fill the cavity.

Abstract: An electrode assembly, a battery, a battery pack and a vehicle including the same are provided. In the electrode assembly, the uncoated portion of an electrode includes a segment region divided into a plurality of segments, and the segment region includes a plurality of segment groups separated by a group separation pitch along a winding direction. One end of the electrode assembly includes a plurality of segment alignments. In winding turns corresponding to the plurality of segment alignments, group separation pitches of segment groups disposed in a same winding turn are substantially identical, and separation pitches of the segment groups is greater in a winding turn of a region adjacent to the outer circumference of the electrode assembly than in a winding turn of a region adjacent to the core of the electrode assembly.

Abstract: The present invention provides a novel compound having a chromanone or its ring-opening form, phenylpropenone, as backbone and compositions for the preventing or treating multiple myeloma, comprising the same. The compounds of the invention exhibit significant killing effects against various multiple myeloma cell lines and show in vivo anti-cancer effects that exceed those of lenalidomide, a commercially available immunomodulator widely used in the treatment of multiple myeloma and myelodysplastic syndromes. In addition, the compounds of the invention exhibit a significant synergistic effect when co-administered with the thalidomide or its analog lenalidomide, and thus are useful as an efficient therapeutic agent or therapeutic aid agent composition for multiple myeloma which is an incurable disease.

Abstract: A medical treatment system includes a transparent display located between a patient and a medical staff and configured to display, a plurality of interface, first and second gaze trackers respectively mounted on both sides of the transparent display to detect pupils of the medical staff and patient and configured to acquire positional coordinates of the pupils of the medical staff and patient in a three-dimensional space, a region setting unit configured to set a gaze exchange region based on an intersection point where a virtual connection line between the positional coordinates of the pupils of the medical staff and patient intersects a plane of the transparent display, and a control unit configured to rearrange the plurality of interface windows by moving at least one interface window overlapping the gaze exchange region outside the gaze exchange region.

Abstract: The present invention relates to a pharmaceutical composition for the prevention or treatment of cancer, comprising a DEAD-box helicase 54 (DDX54) inhibitor and a cancer immunotherapy agent, and to a combination therapy of cancer immunotherapy. The DDX54 inhibitor according to the present invention can enhance the efficacy of cancer immunotherapy when used in combination with a cancer immunotherapy agent, and the composition containing the DDX54 inhibitor and a cancer immunotherapy agent inhibits proliferation of cancer, which is a key characteristic thereof, and simultaneously inhibits a signal transduction pathway known as an immune evasion mechanism, and thus may be provided for the prevention or treatment of cancer.

Abstract: An apparatus for setting a charging protocol according to an embodiment of the present disclosure includes a profile acquisition unit configured to acquire a resistance profile indicating a corresponding relationship between a state of charge (SOC) and resistance for a battery charged at a predetermined C-rate; and a control unit configured to determine a target SOC satisfying a predetermined condition in the resistance profile, and set a charging protocol including a corresponding relationship between the predetermined C-rate and the target SOC.

Abstract: The present invention relates to: a chimeric antigen receptor comprising an antigen-binding site specifically binding to HLA-G, which is an immune checkpoint; immune cells into which the receptor is introduced; and use thereof. The immune cells can effectively remove cancer cells in which an immune checkpoint is expressed, such that even the activation of endogenous immune cells, which had been suppressed by immune checkpoints, can be expected, and thus can be effectively used as an immunotherapeutic method for various cancer diseases related to HLA-G.

Abstract: A method for providing a rebar arrangement state is provided. The method provides an arrangement state for a plurality of rebars by inputting a rebar image to a pre-trained space detection model to estimate mask regions corresponding to spaces between the plurality of rebars to obtain a plurality of mask regions, classifying the plurality of mask regions into a similar group and a unsimilar group on the basis of similarity in size between the plurality of mask regions, and displaying the plurality of mask regions corresponding to at least one of the similar group or the unsimilar group in the rebar image.

Abstract: A method for providing widgets on a display of a navigation device includes obtaining information about recently executed applications from a user device of a user in a mobility apparatus equipped with the navigation device. The information about the recently executed applications includes execution order information about an order in which the recently executed applications have been executed in the user device. The method also includes determining a display arrangement sequence of widgets of the recently executed applications on a display of the navigation device, based on the execution order information. The method additionally includes displaying the widgets in a first area of the display of the navigation device, based on the determined display arrangement sequence. The first area is positioned at a position adjacent to a side of the display opposite to a driver seat of the mobility apparatus.

Abstract: An electrode rolling apparatus including a non-coating portion pressing part for rolling a non-coating portion of an electrode substrate and an electrode rolling method using the same, making it is possible to prevent a swell from occurring in the non-coating portion region in the process of rolling the electrode substrate and enhance the manufacturing process efficiency.