Abstract: The present disclosure provides a compound of Chemical Formula (1) or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same: wherein X, Z, R1 and R2 are as defined in the specification. The compound of Chemical Formula (1) or pharmaceutically acceptable salt thereof acts as a positive allosteric modulator of metabotropic glutamate receptor subtype 5 (mGluR5), thereby being useful in the prevention or treatment of disorder mediated by glutamate dysfunction and mGluR5.

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating cancer comprising a PIP4K2C inhibitor as an active ingredient. The present invention provides a composition for efficient and radical treatment of cancer by discovering PIP4K2C as a new treatment target for cancer, which exhibits a high recurrence rate and is difficult to radically treat, and selecting a drug that inhibits PIP4K2C among known anticancer drugs.

Abstract: The present disclosure provides a compound of Chemical Formula (1) or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same: wherein X, Z, R1 and R2 are as defined in the specification. The compound of Chemical Formula (1) or pharmaceutically acceptable salt thereof acts as a positive allosteric modulator of metabotropic glutamate receptor subtype 5 (mGluR5), thereby being useful in the prevention or treatment of disorder mediated by glutamate dysfunction and mGluR5.

Abstract: A method of manufacturing a cosmetic product for regenerating a skin cell including generating a water into a magnetized hexagonal water through a magnetized hexagonal water generator, separating a body fat stem cell from a body skin through a first extractor to extract a natural protein from a culture medium of a stem cell including the adipose-derived stem cell, extracting at least one skin beneficial ingredient from the culture medium of the stem cell through a second extractor, extracting a plant extract from at least one plant of a pomegranate, red ginseng, liquorice, ginseng seed, milk vetch, poria cocos, scutellaria, portulaca oleracea, pleuropterus multiflorus, angelica, angelica tenuissima, coix, codonopsis, morus alba and cucumber, and mixing the magnetized hexagonal water, natural protein, the at least one skin beneficial ingredient and the at least one plant extract through a mixer to manufacture a cosmetic product for regenerating a skin cell.

Abstract: A method of manufacturing a cosmetic product for regenerating a skin cell including generating a water into a magnetized hexagonal water through a magnetized hexagonal water generator, separating a body fat stem cell from a body skin through a first extractor to extract a natural protein from a culture medium of a stem cell including the adipose-derived stem cell, extracting at least one skin beneficial ingredient from the culture medium of the stem cell through a second extractor, extracting a plant extract from at least one plant of a pomegranate, red ginseng, liquorice, ginseng seed, milk vetch, poria cocos, scutellaria, portulaca oleracea, pleuropterus multiflorus, angelica, angelica tenuissima, coix, codonopsis, morus alba and cucumber, and mixing the magnetized hexagonal water, natural protein, the at least one skin beneficial ingredient and the at least one plant extract through a mixer to manufacture a cosmetic product for regenerating a skin cell.