Abstract: Disclosed are a biomimic system simulating lung tissue, a method for manufacturing same, and a microfluidic control method using same, wherein the biomimic system comprises lung epithelial cells and lung fibroblasts, which are isolated from human lungs, and commercially available vascular endothelial cells, and wherein a microfluid flows through the biomimic system. Each chamber inside the corresponding system can allow a fluid, which contains gas and a medium, to flow therethrough and simulate respiration-like movement, wherein all of the three types of cells can survive inside the system even when one week or more have elapsed after through-flow of the fluid. In addition, the pH and pO2 in the chamber can be monitored by using a pH sensor and a gas partial pressure sensor inside the system, and thus the three types of cells inside the system can be exposed to external environments, drugs, and the like under the same conditions as in the lungs in vivo.

Abstract: The present specification relates to a system for measuring the metastatic potential of cancer cells and a method for measuring the metastatic potential of cancer cells by using same, the system comprising a microenvironment mimicking part and a measurement unit, in which the microenvironment mimicking part comprises: a primary tumor layer including cancer cells and vascular endothelial cells; and a metastasis layer including a gel. The system according to an aspect of the present invention has excellent effects such as being able to co-culture cancer cells and vascular endothelial cells, mimic the metastasis of cancer cells that is caused by a vascular layer formed by vascular endothelial cells during co-culture, easily observe and measure the metastatic potential of cancer cells by using a marker that is expressed specifically in cancer cells, and mimic the metastasis of cancer cells and measure the metastatic potential thereof.

Abstract: Disclosed are a biomimic system simulating lung tissue, a method for manufacturing same, and a microfluidic control method using same, wherein the biomimic system comprises lung epithelial cells and lung fibroblasts, which are isolated from human lungs, and commercially available vascular endothelial cells, and wherein a microfluid flows through the biomimic system. Each chamber inside the corresponding system can allow a fluid, which contains gas and a medium, to flow therethrough and simulate respiration-like movement, wherein all of the three types of cells can survive inside the system even when one week or more have elapsed after through-flow of the fluid. In addition, the pH and pO2 in the chamber can be monitored by using a pH sensor and a gas partial pressure sensor inside the system, and thus the three types of cells inside the system can be exposed to external environments, drugs, and the like under the same conditions as in the lungs in vivo.