Abstract: Provided are mesenchymal stem cells, a preparation method therefor, and a use thereof, the mesenchymal stem cell having oxidative stress resistance by reducing or inhibiting the expression or activity level of KEAP1, which is a negative regulator of Nrf2, so as to increase the activity of Nrf2.

Abstract: One aspect of the present disclosure is a pharmaceutical composition which includes (R)—N-[1-(3,5-difluoro-4-methansulfonylamino-phenyl)-ethyl]-3-(2-propyl-6-trifluoromethyl-pyridin-3-yl)-acrylamide as a first component and a cellulosic polymer as a second component, wherein the composition of one aspect of the present disclosure has a formulation characteristic in which crystal formation is delayed for a long time.

Abstract: A pressurizing centrifugal dehydrator for removing moisture according to the present disclosure includes: an inner basket into which slurry is introduced; an outer basket surrounding the inner basket; a blocking barrier disposed in the outer basket; and a gas supplying portion for supplying gas into the inner basket and/or the outer basket, wherein a dehydration product is positioned between an outer circumference of the blocking barrier and an inner side of the outer basket to maintain airtightness of the outer basket.

Abstract: The present disclosure relates to an organic electroluminescent compound and an organic electroluminescent device comprising the same. By comprising the compound according to the present disclosure, an organic electroluminescent device having improved driving voltage, power efficiency and/or lifetime characteristics compared to conventional organic electroluminescent devices can be provided.

Abstract: Disclosed is a composition for preventing or treating chronic obstructive pulmonary disease containing regorafenib as an active ingredient, and particularly a pharmaceutical composition for preventing or treating chronic obstructive pulmonary disease containing regorafenib or a pharmaceutically acceptable salt thereof as an active ingredient, in which regorafenib is capable of effectively inhibiting increased immune response, which is a symptom of chronic obstructive pulmonary disease, and of improving and restoring changed lung structure and damaged lung function, and can be effectively used for the manufacture of a medicament for the prevention, amelioration, or treatment of chronic obstructive pulmonary disease, such as emphysema, chronic bronchitis, asthma, or pneumonia.

Abstract: Provided are a novel metallocene-supported catalyst and a method of preparing a polyolefin using the same. The metallocene-supported catalyst according to the present disclosure may be used in the preparation of polyolefins, it may have excellent activity and excellent reactivity with comonomers, and it may prepare olefinic polymers having a high molecular weight and a low molecular weight.

Abstract: Disclosed is a composition for preventing or treating chronic obstructive pulmonary disease containing regorafenib as an active ingredient, and particularly a pharmaceutical composition for preventing or treating chronic obstructive pulmonary disease containing regorafenib or a pharmaceutically acceptable salt thereof as an active ingredient, in which regorafenib is capable of effectively inhibiting increased immune response, which is a symptom of chronic obstructive pulmonary disease, and of improving and restoring changed lung structure and damaged lung function, and can be effectively used for the manufacture of a medicament for the prevention, amelioration, or treatment of chronic obstructive pulmonary disease, such as emphysema, chronic bronchitis, asthma, or pneumonia.

Abstract: Disclosed are an amphiphysin-I mutant having anti-senescence activity and the use thereof. More particularly, disclosed are an amphiphysin-I mutant (AMPH-I) wherein valine (V), which is the 392nd amino acid in the amino acid sequence of amphiphysin-I (AMPH-I) represented by SEQ ID NO: 1, is substituted with glycine (G), a composition for suppressing aging and cellular senescence containing the amphiphysin-I mutant as an active ingredient, a pharmaceutical composition for preventing or treating senescence or a senescence-associated disease, a method for suppressing aging and cellular senescence, and a method for screening an inhibitor for aging and cellular senescence.

Abstract: The present invention relates to use of PAK4 and CRTC1 or the treatment or diagnosis of a degenerative brain disease. Specifically, the present invention relates to a pharmaceutical composition for the prevention or treatment of a degenerative brain disease comprising PAK4 (p21-activated kinase 4) or a PAK4 activator as an effective ingredient.

Abstract: Disclosed are an amphiphysin-I mutant having anti-senescence activity and the use thereof. More particularly, disclosed are an amphiphysin-I mutant (AMPH-I) wherein valine (V), which is the 392nd amino acid in the amino acid sequence of amphiphysin-I (AMPH-I) represented by SEQ ID NO: 1, is substituted with glycine (G), a composition for suppressing aging and cellular senescence containing the amphiphysin-I mutant as an active ingredient, a pharmaceutical composition for preventing or treating senescence or a senescence-associated disease, a method for suppressing aging and cellular senescence, and a method for screening an inhibitor for aging and cellular senescence.

Abstract: Disclosed herein are a G-protein-coupled receptor (GPCR) kinase-interacting protein (GIT) and a use thereof. More particularly, a pharmaceutical composition for prevention or treatment of senescence or senescence-associated disease and a composition for inhibition of cellular senescence, each comprising GIT or a GIT activating agent as an active ingredient, a method for screening a cellular senescence inhibitor, and a method for inhibition of cellular senescence are provided. In senescent cells induced by down-regulation of bPIX expression, GIT or GIT-CT overexpression was found to reduce the expression of senescence markers and to suppress senescence-induced endocytosis reduction. Having an inhibitory activity against cellular senescence, GIT can be thus used as a novel therapeutic agent for senescence or senescence-associated disease.

Abstract: The present invention relates to a method for predicting the physical properties of polymers. More specifically, the present invention relates to a method for predicting the processability of polymers using a molecular weight distribution curve.

Abstract: A wireless power transmitter includes: a power supply configured to supply a driving power; a first power transmitter including first bridge switching elements forming a first bridge circuit, and configured to receive the driving power to transmit a first power, wherein a magnitude of a first input voltage applied to the first bridge circuit is determined by a duty of at least one of the first bridge switching elements; a second power transmitter including second bridge switching elements forming a second bridge circuit, and configured to receive the driving power to transmit a second power, wherein a magnitude of a second input voltage applied to the second bridge circuit is determined by a duty of at least one of the second bridge switching elements; and a controller configured to output first and second power transmitting control signals respectively controlling the first bridge switching elements and the second bridge switching elements.

Abstract: Provided are a novel metallocene-supported catalyst and a method of preparing a polyolefin using the same. The metallocene-supported catalyst according to the present disclosure may be used in the preparation of polyolefins, it may have excellent activity and excellent reactivity with comonomers, and it may prepare olefinic polymers having a high molecular weight and a low molecular weight.

Abstract: A wireless power transmitter includes a converter comprising at least one switching element, and configured to generate boosted input power; a resonator and a controller. The resonator is configured to receive the boosted input power as an alternating current (AC) power, and transmit a ping signal in a detection mode for determining whether any one or both of an external object approaching and a type of the external object. The controller is configured to control the switching element, and gradually increase a duty cycle of a gate signal provided to the switching element, in the detection mode.

Abstract: Provided are a novel metallocene-supported catalyst and a method of preparing a polyolefin using the same. The metallocene-supported catalyst according to the present disclosure may be used in the preparation of polyolefins, it may have excellent activity and excellent reactivity with comonomers, and it may prepare olefinic polymers having a high molecular weight and a low molecular weight.

Abstract: A wireless power transmitter includes: a first power transmitting unit including first switching elements forming a first bridge circuit, and configured to receive input DC voltage and transmit a first power by switching operations of the first switching elements; and a second power transmitting unit including second switching elements forming a second bridge circuit, and configured to receive the input DC voltage and transmit second power by switching operations of the second switching elements. The first power transmitting unit steps-up the input DC voltage according to a duty ratio of one or more of the first switching elements, and applies the stepped-up input DC voltage to the first bridge circuit. The second power transmitting unit steps-up or steps-down the input DC voltage according to a duty ratio of one or more of the second switching elements, and applies the stepped-up or stepped-down input DC voltage to the second bridge circuit.

Abstract: There are provided an apparatus for transmitting power wirelessly. The apparatus for transmitting power wirelessly may include a boosting unit boosting an input voltage, and an inverter unit inverting the boosted voltage output from the boosting unit to transmit power wirelessly. The inverter unit and the boosting unit are controlled by the same switching element.

Abstract: A wireless power transmitter includes a converter, a resonator, and a controller. The converter includes switching elements forming a bridge circuit, and is configured to output an alternating current (AC) voltage in response to control signals. The resonator includes a resonant capacitor and a resonant coil, and is configured to receive the AC voltage to wirelessly transmit power. The controller is configured to perform a first mode operation in which a duty of the control signals is fixed, a frequency of one of the control signals is varied and the control signals are output, and a second mode operation in which a frequency of the control signals is fixed, a duty of one of the control signals is reduced and the control signals are output.

Abstract: The present invention relates to a supported hybrid catalyst and a method for preparing olefin polymer using the same. Using the supported hybrid catalyst, olefin polymer that maintains excellent mechanical strength of olefin polymer polymerized with the existing metallocene catalyst, but exhibits remarkably improved processibility compared to the existing olefin polymer, can be provided.