Patents by Inventor Eunice E. Kim

Eunice E. Kim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Molecules comprising a calcineurin-like binding pocket and encoded data storage medium capable of graphically displaying them
    Patent number: 7065452
    Abstract: The present invention relates to crystallized molecules and molecular complexes which comprise the active site binding pocket or the FKBP12/FK506 binding pocket of calcineurin or close structural homologues to either binding pocket. This invention also relates to a data storage material encoded with the corresponding structure coordinates of those crystallized molecules or molecular complexes. Such data storage material is capable of displaying such molecules and molecular complexes as a graphical three-dimensional representation on a computer screen. In addition, this invention relates to methods of using the structure coordinates of those molecules or molecular complexes to solve the structure of homologous proteins. This invention also relates to methods of using the structure coordinates to screen and design compounds that bind to calcineurin or homologues thereof.
    Type: Grant
    Filed: November 1, 1999
    Date of Patent: June 20, 2006
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: David M. Armistead, Matthew James Fitzgibbon, Mark Andrew Fleming, James P. Griffith, Eunice E. Kim, Joseph L. Kim, Michael D. Sintchak, John Allan Thomson, Keith P. Wilson
  • Crystal structure and mutants of interleukin-1.beta. converting enzyme
    Patent number: 6057119
    Abstract: Interleukin-1.beta. converting enzyme ("ICE") processes an inactive precursor to the pro-inflammatory cytokine, interleukin-1.beta.. The high-resolution structure of human ICE crystallized in complex with an inhibitor is determined by X-ray diffraction. The active site spans both the 10 and 20 kilodalton subunits. The accessory binding site is composed of residues from the p10 and p20 subunits that are adjacent to the two-fold axis of the crystal. The structure coordinates of the enzyme may be used to design novel classes of ICE inhibitors.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: May 2, 2000
    Assignee: Vertex Pharmaceuticals, Incorporated
    Inventors: Keith P. Wilson, James P. Griffith, Eunice E. Kim, David J. Livingston
  • Molecules comprising a calcineurin-like binding pocket and encoded data storage medium capable of graphically displaying them
    Patent number: 5978740
    Abstract: The present invention relates to crystallized molecules and molecular complexes which comprise the active site binding pocket or the FKBP12/FK506 binding pocket of calcineurin or close structural homologues to either binding pocket. This invention also relates to a data storage material encoded with the corresponding structure coordinates of those crystallized molecules or molecular complexes. Such data storage material is capable of displaying such molecules and molecular complexes as a graphical three-dimensional representation on a computer screen. In addition, this invention relates to methods of using the structure coordinates of those molecules or molecular complexes to solve the structure of homologous proteins. This invention also relates to methods of using the structure coordinates to screen and design compounds that bind to calcineurin or homologues thereof.
    Type: Grant
    Filed: August 9, 1995
    Date of Patent: November 2, 1999
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: David M. Armistead, Matthew James Fitzgibbon, Mark Andrew Fleming, James P. Griffith, Eunice E. Kim, Joseph L. Kim, Michael D. Sintchak, John Allan Thomson, Keith P. Wilson
  • Crystal structure and mutants of interleukin-1 beta converting enzyme
    Patent number: 5856116
    Abstract: Interleukin-1.beta. converting enzyme ("ICE") processes an inactive precursor to the pro-inflammatory cytokine, interleukin-1.beta.. The high-resolution structure of human ICE crystallized in complex with an inhibitor is determined by X-ray diffraction. The active site spans both the 10 and 20 kilodalton subunits. The accessory binding site is composed of residues from the p10 and p20 subunits that are adjacent to the two-fold axis of the crystal. The structure coordinates of the enzyme may be used to design novel classes of ICE inhibitors.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: January 5, 1999
    Assignee: Vertex Pharmaceuticals, Incorporated
    Inventors: Keith P. Wilson, James P. Griffith, Eunice E. Kim, David J. Livingston