Abstract: Plasmonic nanostructures function as an antenna-reactor nanostructure to focus and convert light into thermal/chemical energy, and thus have significant potential for sustainable solar water disinfection. However, the insufficient energy harvesting efficiency resulting from inconsistent nano-features linked with arrangement and scaling is a persistent challenge. An integrated optofluidic fabrication method is presented to produce a high density integrative plasmonic dimer array to enhance solar water disinfection. The plasmonic dimer array is constructed by a combined fabrication of self-assembly monolayer method and block-co-polymer lithography approaches. This combination leads to a two-dimensional hexagonal array of dimer structures consisting of 1.3 nm nanogap. The uniformity and high density of the nanogaps in the plasmonic dimer array allows strong light focusing and a rapid and highly efficient harvesting of photothermal energy at visible and near-infrared region.

Abstract: The present disclosure relates to dosing regimens comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione compounds or pharmaceutical compositions, pharmaceutical formulations, or combinations comprising the same; and methods of using such compounds, combinations, and compositions in the treatment or prevention IKAROS Family Zinc Finger 2 (IKZF2)-dependent diseases or disorders or where reduction of IKZF2 or IKZF4 protein levels can ameliorate a disease, for example, the treatment of cancers.

Abstract: Precise polarimetric imaging of polarization-sensitive nanoparticles is essential to resolving their accurate spatial positions beyond the diffraction limit. However, conventional technologies typically employ mechanically rotated optical components, causing beam deviation errors that cannot be corrected beyond the diffraction limit. To overcome this limitation, a spatially stable nano-imaging system is presented for polarization-sensitive nanoparticles. In this disclosure, it is demonstrated that by integrating a voltage-tunable polarizer into optical microscopy, one is able to achieve high precision nano-imaging without mechanically induced image shift. It is also demonstrated that by integrating a voltage-tunable polarizer into photographic imaging system, one can achieve high-speed suppression of reflection glare and/or high-speed variation light exposure to the imager.

Abstract: A method is presented for reducing glare in images captured by an imaging system. As a starting point, multiple images of a scene are captured by an imaging system to form a set of images, where the imaging system includes a voltage tunable polarizer and each image in the set of images is captured with the voltage tunable polarizer set at a different polarization angle. The method further includes: partitioning each image in the set of images into a plurality of segments; for corresponding segments in the set of images, determining an amount of change in intensity across corresponding segments of images; quantifying the amount of intensity change for each image in the set of images; and identifying a given image from the set of images based on the quantified amount of intensity change, where the given image has least amount of intensity change amongst the set of images.

Abstract: An image reconstruction method includes capturing a reference image of the specimen and capturing a set of original images based on the reference image. The method includes generating a set of analyzed images based on the set of original images by determining an intensity distribution for each pixel of each original image of the set of original images and combining the intensity distribution at each pixel location across the set of original images into an intermediate image. The method includes, identifying an object in the intermediate image. In response to identifying the object in the intermediate image, determining an intensity value of the object in each original image of the set of original images and generating an improved image of the object based on the determined intensity value of the object. The method includes generating a final image including the improved image of the object and displaying the final image.

Abstract: A mobile video game uses real world anchor points in providing for video game play which includes virtual elements. The real world anchor points may be specified in terms of a geographic coordinate system, and game play may be based on mobile device presence at or about the anchor points.

Abstract: Precise polarimetric imaging of polarization-sensitive nanoparticles is essential to resolving their accurate spatial positions beyond the diffraction limit. However, conventional technologies typically employ mechanically rotated optical components, causing beam deviation errors that cannot be corrected beyond the diffraction limit. To overcome this limitation, a spatially stable nano-imaging system is presented for polarization-sensitive nanoparticles. In this disclosure, it is demonstrated that by integrating a voltage-tunable polarizer into optical microscopy, one is able to achieve high precision nano-imaging without mechanically induced image shift. It is also demonstrated that by integrating a voltage-tunable polarizer into photographic imaging system, one can achieve high-speed suppression of reflection glare and/or high-speed variation light exposure to the imager.

Abstract: A method is presented for reducing glare in images captured by an imaging system. As a starting point, multiple images of a scene are captured by an imaging system to form a set of images, where the imaging system includes a voltage tunable polarizer and each image in the set of images is captured with the voltage tunable polarizer set at a different polarization angle. The method further includes: partitioning each image in the set of images into a plurality of segments; for corresponding segments in the set of images, determining an amount of change in intensity across corresponding segments of images; quantifying the amount of intensity change for each image in the set of images; and identifying a given image from the set of images based on the quantified amount of intensity change, where the given image has least amount of intensity change amongst the set of images.

Abstract: An image reconstruction method includes capturing a reference image of the specimen and capturing a set of original images based on the reference image. The method includes generating a set of analyzed images based on the set of original images by determining an intensity distribution for each pixel of each original image of the set of original images and combining the intensity distribution at each pixel location across the set of original images into an intermediate image. The method includes, identifying an object in the intermediate image. In response to identifying the object in the intermediate image, determining an intensity value of the object in each original image of the set of original images and generating an improved image of the object based on the determined intensity value of the object. The method includes generating a final image including the improved image of the object and displaying the final image.

Abstract: A mobile video game uses real world anchor points in providing for video game play which includes virtual elements. The real world anchor points may be specified in terms of a geographic coordinate system, and game play may be based on mobile device presence at or about the anchor points.

Abstract: A nanoscale temperature sensor is presented that is based on mechano-optical sensing. The temperature sensor features a nanoscale bilayer sensing member with a footprint of <100 nm. The sensing member is composed of two layers of materials with similar elastic modulus but different coefficients of thermal expansion. This difference in coefficients of thermal expansion causes the sensing member to mechanically deform upon temperature change. The deformation of the sensing member alters its optical properties, allowing the temperature measurement to be achieved by far field imaging with high throughput. Both the mechanical and optical properties of the sensing member are reversible thus allow stable and repeatable measurement.

Abstract: A system for monitoring strain as an indicator of biological conditions, such as spinal fusion, glucose levels, spinal loading, and heart rate. The system includes an inter-digitated capacitor sensor, and RF transmitter, and an associated antenna, all of which are microminiature or microscopic in size and can be implanted in a biological host such as a human or animal. An inductively coupled power supply is also employed to avoid the need for implantation of chemical batteries. Power is provided to the sensor and transmitter, and data is transmitted from the sensor, when an external receiving device, such as a handheld RF ID type receiver, is placed proximate the location of the implanted sensor, transmitter and inductively coupled power supply. The implanted sensor, transmitter and inductively coupled power supply can be left in place permanently or removed when desired.

Abstract: A selectively addressable optical biomolecular carrier and its method of use for reconfiguring gene circuits are described. One carrier is a plasmon resonant nanoantenna formed from a gold metal nanorod coated with a cationic phospholipid bilayer with an aspect ratio between 2.0 and 8.0 and plasmon resonance wavelength in the near infrared range. Biomolecules such as siRNA adhere to the carrier and are introduced into a cell. The biomolecules are released from the nanoantenna carriers with exposure to light at the plasmon resonance wavelength. The nanoantenna efficiently converts absorbed optical energy to surface localized heat releasing the biomolecules at a time determined by the user. The carrier can be used to modify gene circuits by allowing temporal control over the genes within a selected gene circuit through the optical release of interfering nucleotides. Optical silencing of endogenous genes with siRNA released from nanoantenna carriers was used to illustrate the methods.

Abstract: A system for monitoring strain as an indicator of biological conditions, such as spinal fusion, glucose levels, spinal loading, and heart rate. The system includes an inter-digitated capacitor sensor, and RF transmitter, and an associated antenna, all of which are microminiature or microscopic in size and can be implanted in a biological host such as a human or animal. An inductively coupled power supply is also employed to avoid the need for implantation of chemical batteries. Power is provided to the sensor and transmitter, and data is transmitted from the sensor, when an external receiving device, such as a handheld RF ID type receiver, is placed proximate the location of the implanted sensor, transmitter and inductively coupled power supply. The implanted sensor, transmitter and inductively coupled power supply can be left in place permanently or removed when desired.

Abstract: A system for monitoring strain as an indicator of biological conditions, such as spinal fusion, glucose levels, spinal loading, and heart rate. The system includes an inter-digitated capacitor sensor, and RF transmitter, and an associated antenna, all of which are microminiature or microscopic in size and can be implanted in a biological host such as a human or animal. An inductively coupled power supply is also employed to avoid the need for implantation of chemical batteries. Power is provided to the sensor and transmitter, and data is transmitted from the sensor, when an external receiving device, such as a handheld RF ID type receiver, is placed proximate the location of the implanted sensor, transmitter and inductively coupled power supply. The implanted sensor, transmitter and inductively coupled power supply can be left in place permanently or removed when desired.

Abstract: A system for monitoring strain as an indicator of biological conditions, such as spinal fusion, glucose levels, spinal loading, and heart rate. The system includes an inter-digitated capacitor sensor, and RF transmitter, and an associated antenna, all of which are microminiature or microscopic in size and can be implanted in a biological host such as a human or animal. An inductively coupled power supply is also employed to avoid the need for implantation of chemical batteries. Power is provided to the sensor and transmitter, and data is transmitted from the sensor, when an external receiving device, such as a handheld RF ID type receiver, is placed proximate the location of the implanted sensor, transmitter and inductively coupled power supply. The implanted sensor, transmitter and inductively coupled power supply can be left in place permanently or removed when desired.

Abstract: A system for monitoring strain as an indicator of biological conditions, such as spinal fusion, glucose levels, spinal loading, and heart rate. The system includes an inter-digitated capacitor sensor, and RF transmitter, and an associated antenna, all of which are microminiature or microscopic in size and can be implanted in a biological host such as a human or animal. An inductively coupled power supply is also employed to avoid the need for implantation of chemical batteries. Power is provided to the sensor and transmitter, and data is transmitted from the sensor, when an external receiving device, such as a handheld RF ID type receiver, is placed proximate the location of the implanted sensor, transmitter and inductively coupled power supply. The implanted sensor, transmitter and inductively coupled power supply can be left in place permanently or removed when desired.

Abstract: A system for monitoring strain as an indicator of biological conditions, such as spinal fusion, glucose levels, spinal loading, and heart rate. The system includes an inter-digitated capacitor sensor, and RF transmitter, and an associated antenna, all of which are microminiature or microscopic in size and can be implanted in a biological host such as a human or animal. An inductively coupled power supply is also employed to avoid the need for implantation of chemical batteries. Power is provided to the sensor and transmitter, and data is transmitted from the sensor, when an external receiving device, such as a handheld RF ID type receiver, is placed proximate the location of the implanted sensor, transmitter and inductively coupled power supply. The implanted sensor, transmitter and inductively coupled power supply can be left in place permanently or removed when desired.

Abstract: A system for monitoring strain as an indicator of biological conditions, such as spinal fusion, glucose levels, spinal loading, and heart rate. The system includes an inter-digitated capacitor sensor, and RF transmitter, and an associated antenna, all of which are microminiature or microscopic in size and can be implanted in a biological host such as a human or animal. An inductively coupled power supply is also employed to avoid the need for implantation of chemical batteries. Power is provided to the sensor and transmitter, and data is transmitted from the sensor, when an external receiving device, such as a handheld RF ID type receiver, is placed proximate the location of the implanted sensor, transmitter and inductively coupled power supply. The implanted sensor, transmitter and inductively coupled power supply can be left in place permanently or removed when desired.

Abstract: A system for monitoring strain as an indicator of biological conditions, such as spinal fusion, glucose levels, spinal loading, and heart rate. The system includes an inter-digitated capacitor sensor, and RF transmitter, and an associated antenna, all of which are microminiature or microscopic in size and can be implanted in a biological host such as a human or animal. An inductively coupled power supply is also employed to avoid the need for implantation of chemical batteries. Power is provided to the sensor and transmitter, and data is transmitted from the sensor, when an external receiving device, such as a handheld RF ID type receiver, is placed proximate the location of the implanted sensor, transmitter and inductively coupled power supply. The implanted sensor, transmitter and inductively coupled power supply can be left in place permanently or removed when desired.