Abstract: The subject compounds are ester, thioester, amide, hydrazide and anhydride derivatives of 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylic acid. These compounds are prepared by reacting the aforementioned acid with the appropriate alcohol, thiol, amine, or the like in the presence of a suitable dehydrating agent, or by reacting the acid chloride derivative of the aforementioned acid with the appropriate alcohol, thiol, amine or the like. A further embodiment of this invention is N-oxide derivative of 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylic acid. This N-oxide compound is prepared by peracid treatment of the mentioned acid. The instant compounds share various valuable pharmacological properties, including analgesic and especially potent antidiarrheal properties.

Abstract: Preparation of the subject compounds by reaction of 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylic acid with an N-hydroxy compound of the type HO--N Q wherein ##EQU1## represents an optionally substituted monocyclic- or fused polycylic-heterocyclic radical containing at least one carbonyl function adjacent the nitrogen atom, in the presence of a suitable dehydrating agent, and their useful biological properties, including analgesic and especially potent antidiarrheal activity are disclosed.

Abstract: 2-(2-Methyl-5-nitro-1-imidazolyl)ethyl esters of cycloaminocarbodithioates are herein described. These compounds are anti-protozoal and anti-fungal agents. The compounds are prepared in 2 steps. The reaction of the appropriate cycloamine with carbon disulfide in aqueous base forms the aminocarbodithioate salt and the final products are formed by the reaction of this salt with 1-(2-chloroethyl)-2-methyl-5-nitroimidazole.