Patents by Inventor Eusebio Manchado-Robles

Eusebio Manchado-Robles has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibodies to PMEL17 and conjugates thereof
    Patent number: 11779649
    Abstract: This application discloses anti-PMEL17 antibodies, antigen binding fragments thereof, and antibody drug conjugates comprising antibodies or antigen binding fragments conjugated to a GNAQ/GNA11 inhibitor. The application also discloses methods of treating or preventing cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.
    Type: Grant
    Filed: December 18, 2019
    Date of Patent: October 10, 2023
    Assignee: Novartis AG
    Inventors: Matthew Burger, Joseph Anthony D'Alessio, Tony Fleming, Vivek Rauniyar, Eusebio Manchado Robles, Christian Kunz, Markus Waldhuber
  • Synergistic cancer treatment
    Patent number: 10792284
    Abstract: The use of mitogen activated kinase inhibition therapy in combination with receptor tyrosine kinase therapy for the treatment of cancer is described.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: October 6, 2020
    Assignee: Memorial Sloan Kettering Cancer Center
    Inventors: Scott W. Lowe, Neal Rosen, Eusebio Manchado-Robles, Susann Weissmueller
  • ANTIBODIES TO PMEL17 AND CONJUGATES THEREOF
    Publication number: 20200197528
    Abstract: This application discloses anti-PMEL17 antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments conjugated to a GNAQ/GNA11 inhibitor. The invention also relates to methods of treating or preventing cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.
    Type: Application
    Filed: December 18, 2019
    Publication date: June 25, 2020
    Inventors: Matthew BURGER, Joseph Anthony D'Alessio, Tony FLEMING, Vivek RAUNIYAR, Eusebio Manchado ROBLES
  • METHOD OF TREATING DISEASES USING KINASE MODULATORS
    Publication number: 20190077856
    Abstract: Provided herein are methods of modulating immune response, including methods of treating a cancer or an infection using a combination of kinase modulators and immunotherapy that promotes immune response. Also provided herein are methods of treating an autoimmune disease or graft-versus-host disease, and methods of reducing the risk of solid organ transplant rejection using a combination of kinase modulators and immunosuppressive therapy.
    Type: Application
    Filed: March 13, 2017
    Publication date: March 14, 2019
    Applicant: Memorial Sloan Kettering Cancer Center
    Inventors: David A. Scheinberg, Elliot Joseph Brea, Claire Y. Oh, Eusebio Manchado-Robles, Ralph James Garippa
  • SYNERGISTIC CANCER TREATMENT
    Publication number: 20180036309
    Abstract: The use of mitogen activated kinase inhibition therapy in combination with receptor tyrosine kinase therapy for the treatment of cancer is described.
    Type: Application
    Filed: February 12, 2016
    Publication date: February 8, 2018
    Inventors: Scott W. Lowe, Neal Rosen, Eusebio Manchado-Robles, Susann Weissmueller