Abstract: Apparatuses, systems, and methods for prosthetic valves. Embodiments of prosthetic valves may be directed to sealing flow at an implantation site, which may comprise a native valve. Embodiments may be configured to conform to a shape of a native valve, which may be a non-circular shape. Embodiments may include a frame having portions coupled together by one or more rotation joints. Embodiments may include a crescent shaped frame. Embodiments may include a construction of a frame having integral portions. Embodiments may include a portion of a prosthetic valve having a micropattern applied to the prosthetic valve. One or more microbeads may be utilized in embodiments. A construction of a prosthetic valve utilizing a support ring may be provided.

Abstract: A radiopaque frame is transluminally advanced to an atrium of a heart of a subject. The frame is expanded within a valve adjacent the atrium such that part of the frame remains disposed in the atrium. While the frame remains expanded within the valve, progressive portions of an annuloplasty structure are progressively positioned and anchored around the annulus using multiple anchors by, for each of the anchors sequentially (i) while fluoroscopically imaging the frame and a distal end of a delivery tool, and facilitated by mechanical guidance from the frame, positioning the distal end of the delivery tool between the frame and a wall of the atrium; and (ii) driving the anchor into the annulus laterally from the frame. Subsequently, the frame is contracted and withdrawn from the subject while leaving the annuloplasty structure anchored around the annulus. Other embodiments are also described.