Abstract: A method of treating a finely divided powder is provided including a) forcing the powder through the apertures of a sieve to form agglomerates; and b) spheronizing the agglomerates. The method results in spheronized agglomerates having sufficient strength to withstand processing and packaging operations, but which are sufficiently soft to deagglomerate during delivery via a breath-actuated inhaler.

Abstract: The present invention relates to a process for providing a stable crystallinic form to a fine-grained substance or a substance mixture, which can be produced, stored and used while maintaining the aerodynamic properties required for inhalation of such a substance or a substance mixture, bya) in case of a substance mixture, preparing a homogenous mixture of the substances;b) micronizing, direct precipitating or diminishing by any conventional method the substance or substance mixture into a particle size required for inhalation, the particle size being less than 10 .mu.m;c) optionally preparing a homogenous mixture of the desired substances when each substance has been introduced from stage b) as separate fine-grained particles;d) conditioning said substance or substance mixture by treatment with a water containing vapor phase in a controlled fashion; ande) drying.