Abstract: What is described herein relates to a method for generating micro-particles comprising the steps of a) providing a homogenous supersaturated solution of a substance in a crystallization medium b) providing a seeding material characterized by a nano-particle size of a d50 between 10 nm and 999 nm comprising at least one stabilizer, wherein said seeding material is of the same substance as the substance of the homogenous supersaturated solution of step a) c) bringing the homogenous supersaturated solution in contact with the seeding material, optionally isolating micro-particles.

Abstract: What is described herein relates to a method for generating micro-particles comprising the steps of a) providing a homogenous supersaturated solution of a substance in a crystallization medium b) providing a seeding material characterized by a nano-particle size of a d50 between 10 nm and 999 nm comprising at least one stabilizer, wherein said seeding material is of the same substance as the substance of the homogenous supersaturated solution of step a) c) bringing the homogenous supersaturated solution in contact with the seeding material, optionally isolating micro-particles.

Abstract: The present disclosure provides a medical assembly comprising a surgical barrier aspect comprising polylactic acid, and a hydrophilic mucoadhesive aspect, wherein the surgical barrier aspect is provided on a first side of the assembly and the mucoadhesive aspect is provided on a second side of the assembly. The disclosure also relates to a medical assembly comprising a surgical barrier aspect, a short term mucoadhesive aspect, an intermediate term protein polymerization adhesive aspect, and a long term tissue ingrowth implant localization aspect. The aforementioned medical assemblies may be provided as layered sheet structures. Also provided are methods for preparing a medical assembly.

Abstract: Described are mono- and bi-layer alginate post-surgical anti-adhesion barriers with tailored absorption profiles and non-migrating characteristics. Muco-adhesive properties of alginates in their solid state are used to localize the device, and lubricious properties of alginates in their liquid state are used to mitigate adhesion formation during wound healing. In addition, the design of the implant can be selected such that the crosslinking agent is released from the device under specific conditions and the absorbance profile modified. A medicinal agent may optionally be incorporated.