Patents by Inventor Eva gai nee Csongor

Eva gai nee Csongor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of N-sulfamyl-3-(2-guanidino-thiazol-4-methylthio)-propionamidine
    Patent number: 4835281
    Abstract: The invention relates to a new process for the preparation of N-sulfamyl-3-(2-guanidinothiazol-4-yl-methylthio)-propionitrile (famotidine) of the formula (I) ##STR1## by S-alkylation of 2-guanidino-thiazol-4-yl-methanethiol obtained from S-(2-guanidino-thiazol-4-yl-methyl)-isothiourea dihydrochloride of the formula (III) ##STR2## by in situ treatment with a base, which comprises carrying out S-alkylation with a N-sulfamyl-3-halopropionamidine of the formula (II) ##STR3## wherein X stands for halogen.
    Type: Grant
    Filed: July 23, 1987
    Date of Patent: May 30, 1989
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Peter Bod, Kalman Harsanyi, Eva gai nee Csongor, Erik Bogsch, Eva Fekecs, Ferenc Trischler, Gyorgy Domany, Istvan Szabadkai, Bela Hegedus
  • N-sulfamyl-3-halopropionamidines
    Patent number: 4731479
    Abstract: The invention relates to new propionamidine derivatives of formula (I) ##STR1## wherein X is halogen,and to a process for their preparation. According to the invention compounds of the formula (I) are prepared by reacting a 3-halopropionitrile of the formula (III) ##STR2## wherein X is as defined above,with sulfamide of the formula (II) ##STR3## in the presence of a hydrogen halide. Compounds of the formula (I) are useful intermediates in the preparation of famotidine.
    Type: Grant
    Filed: September 10, 1986
    Date of Patent: March 15, 1988
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Peter Bod, Kalman Harsanyi, Eva gai nee Csongor, Erik Bogsch, Eva Fekecs, Ferenc Trischler, Gyorgy Domany, Istvan Szabadkai, Bela Hegedus