Patents by Inventor Eva Kohlstrung

Eva Kohlstrung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Optimized purification process of recombinant growth factor protein
    Patent number: 8187837
    Abstract: A process for the production of a purified recombinant GDF-5 related protein in prokaryotes comprises the steps of bacterial cell disruption and inclusion body solubilization to obtain a solubilized monomer of a GDF-5 related protein, said process characterized by a) disruption of bacterial cells with a high pressure homogenizer at a disruption pressure between 800 and 900 bar; and/or b) treatment of the recovered inclusion bodies with a denaturing solubilization buffer comprising L-arginine.
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: May 29, 2012
    Assignee: Biopharm Gesellschaft zur biotechnologischen Entwicklung von Pharmaka mbH
    Inventors: Ute Ehringer, Eva Kohlstrung
  • OPTIMIZED PURIFICATION PROCESS OF RECOMBINANT GROWTH FACTOR PROTEIN
    Publication number: 20110160441
    Abstract: A process for the production of a purified recombinant GDF-5 related protein in prokaryotes comprises the steps of bacterial cell disruption and inclusion body solubilization to obtain a solubilized monomer of a GDF-5 related protein, said process characterized by a) disruption of bacterial cells with a high pressure homogenizer at a disruption pressure between 800 and 900 bar; and/or b) treatment of the recovered inclusion bodies with a denaturing solubilization buffer comprising L-arginine.
    Type: Application
    Filed: June 20, 2008
    Publication date: June 30, 2011
    Applicant: Bio harm Gesellschaft zur Biotechnologischen Entwicklung von Pharmaka mbH
    Inventors: Ute Ehringer, Eva Kohlstrung