Patents by Inventor Eva-Maria Mandelkow

Eva-Maria Mandelkow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thiazolhydrazides for treatment of neurodegenerative diseases
    Patent number: 8410152
    Abstract: Described are compounds having a thiazolhydrazide scaffold, pharmaceutically acceptable salts of these compounds and pharmaceutical compositions containing at least one of these compounds together with pharmaceutically acceptable carrier, excipient and/or diluents. Said thiazolhydrazide compounds can be used for prophylaxis and/or treatment of neurodegenerative diseases and conditions.
    Type: Grant
    Filed: November 5, 2007
    Date of Patent: April 2, 2013
    Assignees: Max-Planck-Gesellschaft zur Forderung der Wissenschaften e. V., Technische Universitat Darmstadt, The Provost Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth near Dublin
    Inventors: Eckhard Mandelkow, Eva-Maria Mandelkow, Markus Pickhardt, Jacek Biernat, David George Lloyd, Boris Schmidt, Gregor Larbig
  • Isolated microtubule-associated protein tau peptides and kit
    Patent number: 8163873
    Abstract: A monoclonal antibody which forms an immunological complex with a phosphorylated epitope of an antigen belonging to human abnormally phosphorylated tau proteine. The tau protein can be obtained from a brain homogenate, itself isolated from the cerebral cortex of a patient having Alzheimer's disease.
    Type: Grant
    Filed: November 10, 2008
    Date of Patent: April 24, 2012
    Assignee: N.V. Innogenetics S.A.
    Inventors: Marc Mercken, Eva-Maria Mandelkow, Marc Vandermeeren, Eugeen Vanmechelen, Andre Vandevoorde
  • THIAZOLHYDRAZIDES FOR TREATMENT OF NEURODEGENERATIVE DISEASES
    Publication number: 20100151064
    Abstract: Described are compounds having a thiazolhydrazide scaffold, pharmaceutically acceptable salts of these compounds and pharmaceutical compositions containing at least one of these compounds together with pharmaceutically acceptable carrier, excipient and/or diluents. Said thiazolhydrazide compounds can be used for prophylaxis and/or treatment of neurodegenerative diseases and conditions.
    Type: Application
    Filed: November 5, 2007
    Publication date: June 17, 2010
    Inventors: Eckhard Mandelkow, Eva-Maria Mandelkow, Markus Pickhardt, Jacek Biernat, David George Lloyd, Boris Schmidt, Gregor Larbig
  • Tools for the diagnosis and treatment of Alzheimer's disease
    Patent number: 7408027
    Abstract: The invention relates to epitopes of the tau protein which are specifically occurring in a phosphorylated state in tau protein from Alzheimer paired helical filaments, to protein kinases which are responsible for the phosphorylation of the amino acids of the tau protein giving rise to said epitopes, and to antibodies specific for said epitopes. The invention further relates to pharmaceutical compositions for the treatment or prevention of Alzheimer's disease, to diagnostic compositions and methods for the detection of Alzheimer's disease and to the use of said epitopes for the generation of antibodies specifically detecting Alzheimer tau protein. Additionally, the invention relates to methods for testing drugs effective in dissolving Alzheimer paired helical filaments or preventing the formation thereof.
    Type: Grant
    Filed: August 17, 2000
    Date of Patent: August 5, 2008
    Assignee: Max-Planck-Gesellschaft zur Forderung der Wissenchaften
    Inventors: Eva-Maria Mandelkow, Eckhard Mandelkow, Birgit Lichtenberg-Kraag, Jacek Biernat, Gerard Drewes, Barbara Steiner
  • Treating neurodegenerative conditions
    Publication number: 20060223812
    Abstract: The present invention relates to the use of compounds capable of inhibiting protein aggregate formation and capable of depolymerising protein aggregates for the preparation of a pharmiaceutical composition for treating neurodegenerative conditions such as Alzheimer disease.
    Type: Application
    Filed: February 10, 2006
    Publication date: October 5, 2006
    Applicant: MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNGDER WISSENSCHAFTEN, E.V.
    Inventors: Eckhard Mandelkow, Eva-Maria Mandelkow, Jacek Biernat, Martin Bergen, Marcus Pickhardt
  • Monoclonal antibodies directed against the microtubule-associated protein tau and method of detecting the same
    Publication number: 20060008853
    Abstract: A monoclonal antibody which forms an immunological complex with a phosphorylated epitope of an antigen belonging to human abnormally phosphorylated tau protein. The tau protein can be obtained from a brain homogenate, itslf isolated from the cerebral cortex of a patient having Alzheimer's disease. Further, a method of detecting the tau protein is claimed.
    Type: Application
    Filed: August 20, 2004
    Publication date: January 12, 2006
    Applicant: N.V. Innogenetics S.A.
    Inventors: Marc Mercken, Eva-Maria Mandelkow, Marc Vandermeeren, Eugeen Vanmechelen, Andre Van De Voorde
  • Monoclonal antibodies directed against the microtubule-associated protein tau
    Patent number: 6900293
    Abstract: A monoclonal antibody which forms an immunological complex with a phosphorylated epitope of an antigen belonging to human abnormally phosphorylated tau protein. The tau protein ca be obtained from a brain homogenate, itself isolated from the cerebral cortex of a patient having Alzheimer's disease.
    Type: Grant
    Filed: December 11, 2000
    Date of Patent: May 31, 2005
    Assignee: N.V. Innogenetics S.A.
    Inventors: Marc Mercken, Eva-Maria Mandelkow, Marc Vandermeeren, Eugeen Vanmechelen, André Van De Voorde
  • NOVEL METHODS FOR TESTING INHIBITORS OF PAIRED HELICAL FILAMENTS AND USES FOR TREATMENT OF ALZHEIMER'S DISEASE
    Publication number: 20020197737
    Abstract: The present invention relates to the use of inhibitors of intracellular polyanions, for example of RNA or polyanionic polypeptides, or derivatives thereof for the prevention or treatment of Alzheimer disease. In addition, the present invention relates to methods for testing inhibitors for their capacity to inhibit PHF formations and to kits useful in carrying out such methods.
    Type: Application
    Filed: September 7, 1999
    Publication date: December 26, 2002
    Inventors: ECKHARD MANDELKOW, EVA MARIA MANDELKOW, JACEK BIERNAT, PETER FRIEDHOFF
  • Monoclonal antibodies directed against the microtubule-associated protein tau
    Publication number: 20010018191
    Abstract: A monoclonal antibody which forms an immunological complex with a phosphorylated epitope of an antigen belonging to human abnormally phosphorylated tau protein. The tau protein ca be obtained from a brain homogenate, itself isolated from the cerebral cortex of a patient having Alzheimer's disease.
    Type: Application
    Filed: December 11, 2000
    Publication date: August 30, 2001
    Applicant: N.V. Innogenetics S.A.
    Inventors: Marc Mercken, Eva-Maria Mandelkow, Marc Vandermeeren, Eugeen Vanmechelen, Van De Voorde Andre
  • Monoclonal antibodies directed against the microtubule-associated protein tau
    Patent number: 6238892
    Abstract: A monoclonal antibody which forms an immunological complex with a phosphorylated epitope of an antigen belonging to human abnormally phosphorylated tau protein. The tau protein ca be obtained from a brain homogenate, itself isolated from the cerebral cortex of a patient having Alzheimer's disease.
    Type: Grant
    Filed: March 15, 1996
    Date of Patent: May 29, 2001
    Assignee: N.V. Innogenetics S.A.
    Inventors: Marc Mercken, Eva-Maria Mandelkow, Marc Vandermeeren, Eugeen Vanmechelen, André Van De Voorde
  • Method of screening for compounds that dissolve paired helical filaments
    Patent number: 6200768
    Abstract: The invention relates to epitopes of the protein which are specifically occurring in a phosphorylated state in tau protein from Alzheimer paired helical filaments, to protein kinases which are responsible for the phosphorylation of the amino acids of the tau protein giving rise to said epitopes, and to antibodies specific for said epitopes. The invention further relates to pharmaceutical compositions for the treatment or prevention of Alzheimer's disease, to diagnostic compositions and methods for the detection of Alzheimer's disease and to the use of said epitopes for the generation of antibodies specifically detecting Alzheimer tau protein. Additionally, the invention relates to methods for testing drugs effective in dissolving Alzheimer paired helical filaments or preventing the formation thereof.
    Type: Grant
    Filed: November 28, 1994
    Date of Patent: March 13, 2001
    Assignee: Max-Planck-Gesellschaft zur Forderung der Wissenschaften
    Inventors: Eva-Maria Mandelkow, Eckhard Mandelkow, Birgit Lichtenberg-Kraag, Jacek Biernat, Gerard Drewes, Barbara Steiner