Patents by Inventor Eva Mezey

Eva Mezey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of marrow-derived glial progenitor cells as gene delivery vehicles into the central nervous system
    Publication number: 20060134081
    Abstract: The present disclosure relates to a method for introducing a hematopoietic cell into the brain of a mammal, by administering bone marrow-derived progenitor cells into the body of the mammal by intravenous injection. The bone marrow-derived cell is preferably a cell that differentiates into a glial cell. The disclosure also relates to a method for delivery of therapeutic protein molecules into the brain of a mammal, by administering to a mammal an effective amount of bone marrow-derived progenitor cells which contain a gene having a nucleic acid sequence that encodes a functional therapeutic protein. Isolated recombinant cells and a pharmaceutical composition are also provided.
    Type: Application
    Filed: January 25, 2006
    Publication date: June 22, 2006
    Inventors: Martin Eglitis, Eva Mezey, Mary Mouradian
  • Use of marrow-derived glial progenitor cells as gene delivery vehicles into the central nervous system
    Patent number: 7022321
    Abstract: The present disclosure relates to a method for introducing a hematopoietic cell into the brain of a mammal, by administering bone marrow-derived progenitor cells into the body of the mammal by intravenous injection. The bone marrow-derived cell is preferably a cell that differentiates into a glial cell. The disclosure also relates to a method for delivery of therapeutic protein molecules into the brain of a mammal, by administering to a mammal an effective amount of bone marrow-derived progenitor cells which contain a gene having a nucleic acid sequence that encodes a functional therapeutic protein. Isolated recombinant cells and a pharmaceutical composition are also provided.
    Type: Grant
    Filed: April 11, 2002
    Date of Patent: April 4, 2006
    Inventors: Martin A. Eglitis, Eva Mezey, Mary Maral Mouradian
  • Use of marrow-derived glial progenitor cells as gene delivery vehicles into the central nervous system
    Publication number: 20030003087
    Abstract: The present disclosure relates to a method for introducing a hematopoietic cell into the brain of a mammal, by administering bone marrow-derived progenitor cells into the body of the mammal by intravenous injection. The bone marrow-derived cell is preferably a cell that differentiates into a glial cell.
    Type: Application
    Filed: April 11, 2002
    Publication date: January 2, 2003
    Applicant: Department of Health and Human Services
    Inventors: Martin A. Eglitis, Eva Mezey, Mary Maral Mouradian
  • CDNA clone of a rat serotonin transporter and protein encoded thereby
    Patent number: 5552308
    Abstract: The invention described in this disclosure relates to a cloned cDNA encoding the serotonin transporter protein (5HTT) usually found in cells of part of the central nervous system, gut, adrenal gland and in platelets. The invention is further directed to the purified serotonin transporter protein and its use and immunogen for the production of anti-5HTT antibodies. The disclosure also discussses methods for use of the cDNA for diagnostic and treatment applications, and methods for use of permanent cell lines transformed with the serotonin transporter cDNA for pharmaceutical screening. The use of anti-5HTT antibodies as a diagnostic tool is also addressed.
    Type: Grant
    Filed: October 24, 1991
    Date of Patent: September 3, 1996
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Beth J. Hoffman, Eva Mezey, Michael J. Brownstein