Patents by Inventor Eva Sevick-Muraca
Eva Sevick-Muraca has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20160038029Abstract: Systems and methods for near-infrared fluorescence (NIRF) imaging and frequency-domain photon migration (FDPM) measurements. An optical tomography system includes a bed, a wheel, a light source, an image detector, and radio frequency (RF) circuitry. The bed is configured to support an object to be imaged. The wheel is configured to rotate about the bed. The light source is coupled to the wheel. The image detector is coupled to the wheel and disposed to capture images of the object. The RF circuitry is coupled to the light source and the image detector. The RF circuitry is configured to simultaneously generate a modulation signal to modulate the light source, and generate a demodulation signal to modulate a gain of the image detector.Type: ApplicationFiled: March 17, 2014Publication date: February 11, 2016Inventors: Chinmay DARNE, Yujie LU, I-Chih TAN, Banghe ZHU, Eva SEVICK-MURACA
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Patent number: 8084753Abstract: A method and system for non-contact fluorescent optical tomography using patterned illumination is disclosed. The method comprises illuminating a surface of a medium with light from at least one excitation light source to project at least two patterns. Each pattern comprises at least one motif, wherein the medium comprises at least one fluorescent target. The method further comprises for each pattern, measuring excitation light reflected from the medium to generate an excitation data set. In addition, the method comprises, for each pattern, measuring fluorescence emitted from the at least one fluorescent target to generate a fluorescence data set. The method also comprises generating a 3D image of the at least one fluorescent target in the medium by applying iterative algorithm. The iterative algorithm minimizes the difference between a predicted data set based on a mathematical model, and each excitation data set and each fluorescence data set.Type: GrantFiled: March 20, 2007Date of Patent: December 27, 2011Assignee: Baylor College of MedicineInventors: Amit Joshi, Eva Sevick-Muraca
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Publication number: 20110280811Abstract: Novel methods and imaging agents for functional imaging of lymph structures are disclosed herein. Embodiments of the methods utilize highly sensitive optical imaging and fluorescent spectroscopy techniques to track or monitor packets of organic dye flowing in one or more lymphatic structures. The packets of organic dye may be tracked to provide quantitative information regarding lymph propulsion and function. In particular, lymph flow velocity and pulse frequency may be determined using the disclosed methods.Type: ApplicationFiled: July 22, 2011Publication date: November 17, 2011Inventors: Kristen ADAMS, Ruchi SHARMA, John RASMUSSEN, Eva SEVICK-MURACA
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Patent number: 7875260Abstract: Novel imaging agents targeted to a lymph vascular cell receptor and a hyaluranon cell receptor are disclosed. The disclosed imaging agents incorporate biological molecules such as hyaluronic acid which bind to the receptors. Lymph vascular cell receptor expression may be related to the beginnings of tumor formation. As such, embodiments of the imaging agents may be used to stain lymph structures for detailed imaging of lymph architecture as well as serving as potential markers for tumor angiogenesis, tumor metastases, etc.Type: GrantFiled: August 24, 2007Date of Patent: January 25, 2011Assignee: Baylor College of MedicineInventors: Ruchi Sharma, Wei Wang, Eva Sevick-Muraca
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Publication number: 20080064954Abstract: Novel methods and imaging agents for functional imaging of lymph structures are disclosed herein. Embodiments of the methods utilize highly sensitive optical imaging and fluorescent spectroscopy techniques to track or monitor packets of organic dye flowing in one or more lymphatic structures. The packets of organic dye may be tracked to provide quantitative information regarding lymph propulsion and function. In particular, lymph flow velocity and pulse frequency may be determined using the disclosed methods.Type: ApplicationFiled: August 24, 2007Publication date: March 13, 2008Applicant: BAYLOR COLLEGE OF MEDICINEInventors: Kristen Adams, Ruchi Sharma, John Rasmussen, Eva Sevick-Muraca
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Publication number: 20080056999Abstract: Novel imaging agents targeted to a lymph vascular cell receptor and a hyaluranon cell receptor are disclosed. The disclosed imaging agents incorporate biological molecules such as hyaluronic acid which bind to the receptors. Lymph vascular cell receptor expression may be related to the beginnings of tumor formation. As such, embodiments of the imaging agents may be used to stain lymph structures for detailed imaging of lymph architecture as well as serving as potential markers for tumor angiogenesis, tumor metastases, etc.Type: ApplicationFiled: August 24, 2007Publication date: March 6, 2008Applicant: BAYLOR COLLEGE OF MEDICINEInventors: Ruchi Sharma, Wei Wang, Eva Sevick-Muraca
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Publication number: 20080050316Abstract: Methods and imaging agents for imaging epithelial cancer cells in the lymphatic system are disclosed herein. In an embodiment, an imaging agent for imaging cancer cells in a lymphatic system comprises a fluorescent dye conjugated to one or more antibodies. The antibodies are capable of specific binding to an epithelial cell adhesion molecule (Ep-CAM). In addition, embodiments of the imaging agent may be administered to the lymphatic system where the disclosed imaging agents may bind to an epithelial cell adhesion molecule. The bound imaging agents may be excited with excitation light to image cancer cells in the lymphatic system.Type: ApplicationFiled: August 23, 2007Publication date: February 28, 2008Applicant: BAYLOR COLLEGE OF MEDICINEInventors: Kristen Adams, Eva Sevick-Muraca
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Patent number: 7328059Abstract: A system and method for non-invasive biomedical optical imaging and spectroscopy with low-level light is described. The technique includes a modulated light source coupled to tissue to introduce excitation light. Fluorescent light emitted in response to the excitation light is detected with a sensor. The AC intensity and phase of the excitation and detected fluorescent light is provided to a processor operatively coupled to the sensor. A processor employs the measured emission kinetics of excitation and fluorescent light to “map” the spatial variation of one or more fluorescence characteristics of the tissue and generate a corresponding image of the tissue via an output device. The fluorescence characteristic may be provided by exogenous contrast agents, endogenous fluorophores, or both. A technique to select or design an exogenous fluorescent contrast agent to improve image contrast is also disclosed.Type: GrantFiled: May 30, 2001Date of Patent: February 5, 2008Assignee: The Texas A & M University SystemInventors: Eva Sevick-Muraca, Tamara L. Troy, Jeffery S. Reynolds
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Publication number: 20070286468Abstract: A method and system for non-contact fluorescent optical tomography using patterned illumination is disclosed. The method comprises illuminating a surface of a medium with light from at least one excitation light source to project at least two patterns. Each pattern comprises at least one motif, wherein the medium comprises at least one fluorescent target. The method further comprises for each pattern, measuring excitation light reflected from the medium to generate an excitation data set. In addition, the method comprises, for each pattern, measuring fluorescence emitted from the at least one fluorescent target to generate a fluorescence data set. The method also comprises generating a 3D image of the at least one fluorescent target in the medium by applying iterative algorithm. The iterative algorithm minimizes the difference between a predicted data set based on a mathematical model, and each excitation data set and each fluorescence data set.Type: ApplicationFiled: March 20, 2007Publication date: December 13, 2007Applicant: BAYLOR COLLEGE OF MEDICINEInventors: Amit Joshi, Eva Sevick-Muraca
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Patent number: 7187441Abstract: A system (20) and method are disclosed for the self-calibrating, on-line determination of size distribution f(x) and volume fraction ? of a number of particles (P) dispersed in a medium (M) by detecting one or more propagation characteristics of multiply scattered light from the particles (P). The multiply scattered light is re-emitted in response to exposure to a light source (21) configured to provide light at selected wavelengths. The determination includes calculating the isotropic scattering and absorption coefficients for the particles (P) by comparing the incident and detected light to determine a measurement corresponding to the propagation time through the scattering medium (M), and iteratively estimating the size distribution f(x) and volume fraction ? as a function of the coefficients for each of the wavelengths. An estimation approach based on an expected form of the distribution and the mass of the particles is also disclosed.Type: GrantFiled: November 7, 1997Date of Patent: March 6, 2007Assignee: The Texas A&M University SystemInventors: Eva Sevick-Muraca, Joseph Pierce, Steven Richter, Rajesh Shinde, Ganesh Balgi, Jeffrey Kao, Huabei Jiang
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Publication number: 20060017925Abstract: Methods are provided for measuring isotropic scattering coefficients of suspensions using multiply scattered radiation that is modulated in amplitude at selected modulation frequencies. The radiation may be light. Quantities describing diffusion of the multiply scattered radiation are preferably measured at a plurality of distances between source and receiver and a plurality of frequencies. Linear regression techniques are provided for maximizing accuracy of the scattering data at a selected wavelength of a radiation. Methods are provided for inversing an integral equation so as to determine a calculated value of scattering coefficient. Parameters are varied to minimize the difference between the calculated and measured scattering coefficients and thereby to determine volume fraction, particle size distribution and interparticle force between the particles in a suspension.Type: ApplicationFiled: August 16, 2005Publication date: January 26, 2006Inventors: Eva Sevick-Muraca, Zhigang Sun, Yingqing Huang
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Publication number: 20050085732Abstract: According to one embodiment of the invention, a method for biomedical imaging includes directing time-varying excitation light at a surface area of a light scattering material, the material comprising a fluorescent target. Time-varying emission light from the fluorescent target is detected, substantially at a two-dimensional sensor surface, in response to the time-varying excitation light stimulating the fluorescent target. The time-varying emission light is filtered to reject excitation light re-emitted from the material. A three-dimensional image of the fluorescent target is generated based on the detection substantially at the sensor surface.Type: ApplicationFiled: June 18, 2004Publication date: April 21, 2005Inventors: Eva Sevick-Muraca, Alan Thompson, Roy Ranadhir
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Method for characterising particles in supension from frequency domain photon migration measurements
Publication number: 20050073681Abstract: Methods are provided for measuring isotropic scattering coefficients of suspensions using multiply scattered radiation that is modulated in amplitude at selected modulation frequencies. The radiation may be light. Quantities describing diffusion of the multiply scattered radiation are preferably measured at a plurality of distances between source and receiver and a plurality of frequencies. Linear regression techniques are provided for maximizing accuracy of the scattering data at a selected wavelength of a radiation. Methods are provided for inversing an integral equation so as to determine a calculated value of scattering coefficient. Parameters are varied to minimize the difference between the calculated and measured scattering coefficients and thereby to determine volume fraction, particle size distribution and interparticle force between the particles in a suspension.Type: ApplicationFiled: April 3, 2002Publication date: April 7, 2005Inventors: Eva Sevick-Muraca, Zhigang Sun, Yingqing Huang -
Publication number: 20020072677Abstract: A system and method for non-invasive biomedical optical imaging and spectroscopy with low-level light is described. The technique consists of a modulated light source coupled to tissue to introduce excitation light. Fluorescent light emitted in response to the excitation light is detected with a sensor. The AC intensity and phase of the excitation and detected fluorescent light is provided to a processor operatively coupled to the sensor. A processor employs the measured emission kinetics of excitation and fluorescent light to “map” the spatial variation of one or more fluorescence characteristics of the tissue and generate a corresponding image of the tissue via an output device. The fluorescence characteristic may be provided by exogenous contrast agents, endogenous fluorophores, or both. A technique to select or design an exogenous fluorescent contrast agent to improve image contrast is also disclosed.Type: ApplicationFiled: May 31, 2001Publication date: June 13, 2002Inventors: Eva Sevick-Muraca, Tamara L. Troy, Jeffery S. Reynolds
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Patent number: 5818583Abstract: A system and method are disclosed for the self-calibrating, on-line determination of size distribution and volume fraction of a number of particles dispersed in a medium by detecting multiply scattered light from the particles. The multiply scattered light is re-emitted in response to exposure to a light source configured to provide light of time varying intensity at selected wavelengths. The determination includes calculating the isotropic scattering coefficient for the particles at each of a number of wavelengths from the multiply scattered light as a function of an intensity modulation phase shift, and iteratively estimating the size distribution and volume fraction as a function of the isotropic scattering coefficient for each of the wavelengths. An estimation approach based on an expected form of the distribution and the mass of the particles is also disclosed.Type: GrantFiled: November 8, 1996Date of Patent: October 6, 1998Assignee: Purdue Research FoundationInventors: Eva Sevick-Muraca, Joseph Pierce, Huabei Jiang, Jeffery Kao