Patents by Inventor Eva Sipos

Eva Sipos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of a rivaroxaban and intermediates formed in said process
    Patent number: 9556163
    Abstract: The invention relates to a process for the preparation of 5-chloro-N-({(5-S)-2-oxo3-[4-(3-oxo-morj)holine-4-yl)-phenyl]-1,3-oxazolidine-5-yl}-methyl) thiophen-2-carboxamide having the INN rivaroxaban. The invention also relates to intermediates formed in the above process.
    Type: Grant
    Filed: May 4, 2012
    Date of Patent: January 31, 2017
    Assignee: EGIS Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag
    Inventors: Eva Sipos, Gyorgyi Kovanyine Lax, Balazs Havasi, Balazs Volk, Gyorgy Krasznai, Gyorgy Ruzsics, Jozsef Barkoczy, Maria Tothne Lauritz, Gyula Lukacs, Andras Boza, Laszlo Jozsef Hegedus, Maria Julia Taborine Toth, Eva Pecsi
  • Crystalline pharmaceutically active ingredients
    Patent number: 9321733
    Abstract: The present invention is related to crystalline forms of rosuvastatin zinc (2:1) salt. The polymorphs are suitable for use as pharmaceutically active ingredients in the treatment of the diseases of the lipid metabolism including hypercholesterolemia, hyperlipidemia, dyslipidemia or atherosclerosis.
    Type: Grant
    Filed: November 16, 2011
    Date of Patent: April 26, 2016
    Assignee: EGIS Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag
    Inventors: Imre Markovits, Ferenc Jurak, Gyorgyi Kovanyine Lax, Csaba Hamori, Balazs Havasi, Eva Sipos, Balazs Volk, Zsolt Runge, Krisztina Fodorne Kocsmar, Gyula Lukacs, Katalin Kataine Fadgyas, Monika Mezovari
  • Method for the preparation of high-purity pharmaceutical intermediates
    Patent number: 9133132
    Abstract: The present invention is related to intermediates useful in the preparation of pharmaceutically acceptable salts of (+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl]-(3R,5S)-dihydroxy-hept-6-enoic acid and polymorphs of said intermediates, methods for preparation thereof and use thereof.
    Type: Grant
    Filed: November 29, 2011
    Date of Patent: September 15, 2015
    Assignee: EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAG
    Inventors: Gyorgyi Kovanyine Lax, Gyula Simig, Balazs Volk, Ferenc Lorant Bartha, Gyorgy Krasznai, Gyorgy Ruzsics, Eva Sipos, Kalman Nagy, Gyorgy Morovjan, Jozsef Barkoczy, Adrienn Keszthelyi, Janos Imre, Gabor Bagyinszki
  • PROCESS FOR THE PREPARATION OF A RIVAROXABAN AND INTERMEDIATES FORMED IN SAID PROCESS
    Publication number: 20140142303
    Abstract: The invention relates to a process for the preparation of 5-chloro-N-({(5-S)-2-oxo3-[4-(3-oxo-morj)holine-4-yl)-phenyl]-1,3-oxazolidine-5-yl}-methyl) thiophen-2-carboxamide having the INN rivaroxaban. The process is characterized by the reactions according to claim 1. The invention also relates to intermediates formed in the above process.
    Type: Application
    Filed: May 4, 2012
    Publication date: May 22, 2014
    Applicant: EGIS Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag
    Inventors: Eva Sipos, Gyorgyi Kovanyine Lax, Balazs Havasi, Balazs Volk, Gyorgy Krasznai, Gyorgy Ruzsics, Jozsef Barkoczy, Maria Tothne Lauritz, Gyula Lukacs, Andras Boza, Laszlo Jozsef Hegedus, Maria Julia Taborine Toth, Eva Pecsi
  • METHOD FOR THE PREPARATION OF HIGH-PURITY PHARMACEUTICAL INTERMEDIATES
    Publication number: 20130338360
    Abstract: The present invention is related to intermediates useful in the preparation of pharmaceutically acceptable salts of (+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl]-(3R,5S)-dihydroxy-hept-6-enoic acid and polymorphs of said intermediates, methods for preparation thereof and use thereof.
    Type: Application
    Filed: November 29, 2011
    Publication date: December 19, 2013
    Applicant: EGIS Gyogyszergyar Nyilvanosan Mukodo Reszvenytars
    Inventors: Gyorgyi Kovanyine Lax, Gyula Simig, Balazs Volk, Ferenc Lorant Bartha, Gyorgy Krasznai, Gyorgy Ruzsics, Eva Sipos, Kalman Nagy, Gyorgy Morovjan, Jozsef Barkoczy, Adrienn Keszthelyi, Janos Imre, Gabor Bagyinszki
  • CRYSTALLINE PHARMACEUTICALLY ACTIVE INGREDIENTS
    Publication number: 20130296353
    Abstract: The present invention is related to crystalline forms of rosuvastatin zinc (2:1) salt. The polymorphs are suitable for use as pharmaceutically active ingredients in the treatment of the diseases of the lipid metabolism including hypercholesterolemia, hyperlipidemia, dyslipidemia or atherosclerosis.
    Type: Application
    Filed: November 16, 2011
    Publication date: November 7, 2013
    Applicant: EGIS Gyogyszergyar Nyilvanosan Mukodo Reszvenytar- sasag
    Inventors: Imre Markovits, Ferenc Jurak, Gyorgyi Kovanyine Lax, Csaba Hamori, Balazs Havasi, Eva Sipos, Balazs Volk, Zsolt Runge, Krisztina Fodorne Kocsmar, Gyula Lukacs, Katalin Kataine Fadgyas, Monika Mezovari
  • Process for the preparation of rosuvastatin salts
    Patent number: 8507513
    Abstract: The present invention relates to a new process for the preparation of rosuvastatin [7-[4-(4-Fluorophenyl)-6-isopropyl-2-(methanesulphonyl-methyl-amino)-pyrimidin-5-yl]-(3R,51S)-dihydroxy-hept-6-enoic acid] of the formula (I) salts formed with bivalent cations, preferably with calcium or zinc ions, characterized in that rosuvastatin tert.-butylammonium salt is reacted with the appropriate bivalent cation, preferably with calcium or zinc ions in a mixture of a water immiscible or slightly miscible organic solvent and water and the formed salt is isolated.
    Type: Grant
    Filed: January 15, 2010
    Date of Patent: August 13, 2013
    Assignee: Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag
    Inventors: Gyoergyi Kovanyine Lax, Eva Sipos, Jozsef Barkoczy, Balazs Volk, Gyula Simig, Ferenc Bartha, Gyoergy Ruzsics, Adrienn Karasz, Imre Kiraly, Kalman Nagy
  • PROCESS FOR THE PREPARATION OF ROSUVASTATIN SALTS
    Publication number: 20120116082
    Abstract: The present invention relates to a new process for the preparation of rosuvastatin [7-[4-(4-Fluorophenyl)-6-isopropyl-2-(methanesulphonyl-methyl-amino)-pyrimidin-5-yl]-(3R,51S)-dihydroxy-hept-6-enoic acid] of the formula (I) salts formed with bivalent cations, preferably with calcium or zinc ions, characterized in that rosuvastatin tert.-butylammonium salt is reacted with the appropriate bivalent cation, preferably with calcium or zinc ions in a mixture of a water immiscible or slightly miscible organic solvent and water and the formed salt is isolated.
    Type: Application
    Filed: January 15, 2010
    Publication date: May 10, 2012
    Inventors: Gyoergyi Kovanyin Lax, Eva Sipos, Jozsef Barkoczy, Balazs Volk, Gyula Simig, Ferenc Bartha, Gyoergy Ruzsics, Adrienn Karasz, Imre Kiraly, Kalman Nagy