Patents by Inventor Eva Surmacz

Eva Surmacz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Adiponectin receptor agonists and methods of use
    Patent number: 9073965
    Abstract: Short peptide mimetics of adiponectin suitable for development as pharmaceutical agonists in the treatment of cellular proliferative disorders such as cancer and atherosclerosis are provided.
    Type: Grant
    Filed: April 11, 2012
    Date of Patent: July 7, 2015
    Assignee: TEMPLE UNIVERSITY—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Laszlo Otvos, Eva Surmacz
  • Leptin antagonist and methods of use
    Patent number: 8778890
    Abstract: This invention provides compounds that are true antagonists of the leptin receptor, in the presence and the absence of native leptin or another leptin receptor binder. These compounds may be used to inhibit leptin receptor activity, promote growth arrest or death of leptin receptor-positive cancer cells, or monitor or detect a leptin receptor-positive cell, in vitro or in vivo. These compounds may also be used to treat a weight-loss nutritional disorder, osteoporosis, rheumatoid arthritis, osteoarthritis, or inflammatory bowel disease. Also included in the invention are methods for detecting leptin receptor-positive cells, for arresting cell growth or killing cancer cells in vivo, for monitoring or detecting a leptin receptor-positive cell in vitro or in vivo, for treating a weight-loss nutritional disorder, for treating osteoporosis, for treating rheumatoid arthritis, for treating osteoarthritis, or for treating inflammatory bowel disease.
    Type: Grant
    Filed: March 30, 2010
    Date of Patent: July 15, 2014
    Assignee: Temple University—of the Commonwealth System of Higher Education
    Inventors: Laszlo Otvos, Eva Surmacz
  • ADIPONECTIN RECEPTOR AGONISTS AND METHODS OF USE
    Publication number: 20140057833
    Abstract: Short peptide mimetics of adiponectin suitable for development as pharmaceutical agonists in the treatment of cellular proliferative disorders such as cancer and atherosclerosis are provided.
    Type: Application
    Filed: April 11, 2012
    Publication date: February 27, 2014
    Applicant: TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Laszlo Otvos, Eva Surmacz
  • Leptin agonist and methods of use
    Patent number: 8470772
    Abstract: Peptides are provided having leptin receptor agonist activity. The peptides are useful for treating obesity, insulin resistance, lipodystrophy and hypothalamic amenorrhea, anorexia-related infertility, among other diseases and conditions related to leptin deficiency and/or leptin resistance.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: June 25, 2013
    Assignee: Temple University—Of The Commonwealth System of Higher Education
    Inventors: Eva Surmacz, Laszlo Otvos, Jr.
  • LEPTIN ANTAGONIST AND METHODS OF USE
    Publication number: 20120142585
    Abstract: This invention provides compounds that are true antagonists of the leptin receptor, in the presence and the absence of native leptin or another leptin receptor binder. These compounds may be used to inhibit leptin receptor activity, promote growth arrest or death of leptin receptor-positive cancer cells, or monitor or detect a leptin receptor-positive cell, in vitro or in vivo. These compounds may also be used to treat a weight-loss nutritional disorder, osteoporosis, rheumatoid arthritis, osteoarthritis, or inflammatory bowel disease. Also included in the invention are methods for detecting leptin receptor-positive cells, for arresting cell growth or killing cancer cells in vivo, for monitoring or detecting a leptin receptor-positive cell in vitro or in vivo, for treating a weight-loss nutritional disorder, for treating osteoporosis, for treating rheumatoid arthritis, for treating osteoarthritis, or for treating inflammatory bowel disease.
    Type: Application
    Filed: March 30, 2010
    Publication date: June 7, 2012
    Applicant: TEMPLE UNIVERSITY-OF THE C0MMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Laszlo Otvos, Eva Surmacz
  • LEPTIN AGONIST AND METHODS OF USE
    Publication number: 20110015124
    Abstract: Peptides are provided having leptin receptor agonist activity. The peptides are useful for treating obesity, insulin resistance, lipodystrophy and hypothalamic amenorrhea, anorexia-related infertility, among other diseases and conditions related to leptin deficiency and/or leptin resistance.
    Type: Application
    Filed: February 27, 2009
    Publication date: January 20, 2011
    Applicant: Temple University of the Commomwealth System of Higher Eduacation
    Inventors: Eva Surmacz, Laszlo Otvos, JR.