Patents by Inventor Evan A. Scott

Evan A. Scott has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12194084
    Abstract: Provided herein are subunit vaccine compositions comprising a nanocarrier and a lipid antigen, a peptide antigen or combinations thereof that elicit bother a CD1-restricted and an MHC-restricted T cell response in a subject. Methods for making and using the subunit vaccine compositions are also provided.
    Type: Grant
    Filed: December 20, 2021
    Date of Patent: January 14, 2025
    Assignee: Northwestern University
    Inventors: Evan A. Scott, Chyung-Ru Wang, Shaobin Shang, Dina Kats
  • Patent number: 12162997
    Abstract: Described herein are flash nanoprecipitation methods capable of encapsulating hydrophobic molecules, hydrophilic molecules, bioactive protein therapeutics, or other target molecules in amphiphilic copolymer nanocarriers.
    Type: Grant
    Filed: September 20, 2021
    Date of Patent: December 10, 2024
    Assignee: Northwestern University
    Inventors: Evan A. Scott, Sean D. Allen
  • Publication number: 20240156743
    Abstract: The present invention provides novel nanostructures comprising solution of PPSU20. Methods of preparing the novel PPSU nanostructures, and applications of such nanostructures are also provided.
    Type: Application
    Filed: September 22, 2023
    Publication date: May 16, 2024
    Inventors: Evan A. Scott, Fanfan Du, Baofu Qiao, Monica Olvera de la Cruz
  • Patent number: 11890353
    Abstract: The present invention provides methods of making an in vivo animal model for detecting anti-poly(ethylene glycol) (PEG) antibodies. The methods of the disclosure comprises administering subcutaneously to an animal model a composition comprising antibodies against poly(ethylene glycol) chains with a molecular weight of at least 550 Da to maintain an anti-PEG antibody level within the animal model. The in vivo animal model can be used for testing and screening drugs and other compositions for adverse reactions, bioavailability, and immunogenicity prior to administration to a human subject.
    Type: Grant
    Filed: October 15, 2020
    Date of Patent: February 6, 2024
    Assignee: Northwestern University
    Inventors: Evan A. Scott, Guillermo A. Ameer, Jacqueline A. Burke, Helena Freire Haddad
  • Patent number: 11801229
    Abstract: The present invention provides novel nanostructures comprising solution of PPSU20. Methods of preparing the novel PPSU nanostructures, and applications of such nanostructures are also provided.
    Type: Grant
    Filed: July 29, 2020
    Date of Patent: October 31, 2023
    Assignee: Northwestern University
    Inventors: Evan A. Scott, Fanfan Du, Baofu Qiao, Monica Olvera de la Cruz
  • Publication number: 20230330022
    Abstract: The present invention provides novel nanostructures comprising solution of PPSU20. Methods of preparing the novel PPSU nanostructures, and applications of such nanostructures are also provided.
    Type: Application
    Filed: July 3, 2023
    Publication date: October 19, 2023
    Inventors: Evan A. Scott, Sijia Yi, David Engman, Xiaomo Li
  • Patent number: 11737978
    Abstract: The present invention provides novel nanostructures comprising solution of PPSU20. Methods of preparing the novel PPSU nanostructures, and applications of such nanostructures are also provided.
    Type: Grant
    Filed: July 29, 2020
    Date of Patent: August 29, 2023
    Assignee: Northwestern University
    Inventors: Evan A. Scott, Sijia Yi, David Engman, Xiaomo Li
  • Publication number: 20230263729
    Abstract: Provided herein are nanocarriers for delivery of immunosuppressive agents. In some embodiments, provided herein are nanocarriers comprising a core comprising a poly(ethylene glycol)-block-poly(propylene sulfide) copolymer and least one therapeutic agent. In some embodiments, the nanocarriers may further comprise a targeting ligand displayed on a surface of the nanocarrier. The at least one therapeutic agent may be an anti-inflammatory agent. The disclosed nanocarriers may be incorporated into pharmaceutical compositions for use in methods of treating an inflammatory condition or preventing transplantation rejection in a subject.
    Type: Application
    Filed: March 2, 2023
    Publication date: August 24, 2023
    Inventors: Evan A. Scott, Guillermo A. Ameer, Jacqueline A. Burke, Sean D. Allen, Sijia Yi
  • Publication number: 20220184197
    Abstract: Provided herein are subunit vaccine compositions comprising a nanocarrier and a lipid antigen, a peptide antigen or combinations thereof that elicit bother a CD1-restricted and an MHC-restricted T cell response in a subject. Methods for making and using the subunit vaccine compositions are also provided.
    Type: Application
    Filed: December 20, 2021
    Publication date: June 16, 2022
    Inventors: Evan A. Scott, Chyung-Ru Wang, Shaobin Shang, Dina Kats
  • Publication number: 20220119510
    Abstract: The present invention provides methods for generating a mouse model that produces anti-polyethylene glycol (PEG) antibodies. Also provided are mice generated by said methods and methods of using these mice to screen PEG-containing products in vivo.
    Type: Application
    Filed: October 15, 2021
    Publication date: April 21, 2022
    Inventors: Evan A. Scott, Guillermo A. Ameer, Helena Freire Haddad, Jacqueline A. Burke
  • Publication number: 20220002502
    Abstract: Described herein are flash nanoprecipitation methods capable of encapsulating hydrophobic molecules, hydrophilic molecules, bioactive protein therapeutics, or other target molecules in amphiphilic copolymer nanocarriers.
    Type: Application
    Filed: September 20, 2021
    Publication date: January 6, 2022
    Inventors: Evan A. Scott, Sean D. Allen
  • Patent number: 11202823
    Abstract: Provided herein are subunit vaccine compositions comprising a nanocarrier and a lipid antigen, a peptide antigen or combinations thereof that elicit bother a CD1-restricted and an MHC-restricted T cell response in a subject. Methods for making and using the subunit vaccine compositions are also provided.
    Type: Grant
    Filed: April 3, 2020
    Date of Patent: December 21, 2021
    Assignee: Northwestern University
    Inventors: Evan A. Scott, Chyung-Ru Wang, Shaobin Shang, Dina Kats
  • Publication number: 20210308065
    Abstract: Provided herein are bicontinuous nanosphere nanocarrier that allow for slow, sustained release or allow for targeted release of target molecules. Further embodiments of the present invention provide bicontinuous nanosphere nanocarrier comprising a photosensitizer and a suitable polymer. Also provided are methods for making and using the photosensitive nanocarrier.
    Type: Application
    Filed: April 5, 2021
    Publication date: October 7, 2021
    Inventors: Evan A. Scott, Sharan Bobbala, Sean D. Allen
  • Patent number: 11124612
    Abstract: Described herein are flash nanoprecipitation methods capable of encapsulating hydrophobic molecules, hydrophilic molecules, bioactive protein therapeutics, or other target molecules in amphiphilic copolymer nanocarriers.
    Type: Grant
    Filed: April 10, 2020
    Date of Patent: September 21, 2021
    Assignee: Northwestern University
    Inventors: Evan A. Scott, Sean D. Allen
  • Publication number: 20210106697
    Abstract: The present invention provides methods of making an in vivo animal model for detecting anti-poly(ethylene glycol) (PEG) antibodies. The methods of the disclosure comprises administering subcutaneously to an animal model a composition comprising antibodies against poly(ethylene glycol) chains with a molecular weight of at least 550 Da to maintain an anti-PEG antibody level within the animal model. The in vivo animal model can be used for testing and screening drugs and other compositions for adverse reactions, bioavailability, and immunogenicity prior to administration to a human subject.
    Type: Application
    Filed: October 15, 2020
    Publication date: April 15, 2021
    Applicant: NORTHWESTERN UNIVERSITY
    Inventors: Evan A. Scott, Guillermo A. Ameer, Jacqueline A. Burke, Helena Freire Haddad
  • Publication number: 20210059938
    Abstract: The present invention provides nanomaterials for the specific targeting of immune cells. Methods of treating cardiac disease and inflammatory disease are also described.
    Type: Application
    Filed: October 30, 2020
    Publication date: March 4, 2021
    Inventors: Evan A. Scott, Sijia Yi, Sean D. Allen
  • Publication number: 20210052498
    Abstract: The present invention provides novel nanostructures comprising solution of PPSU20. Methods of preparing the novel PPSU nanostructures, and applications of such nanostructures are also provided.
    Type: Application
    Filed: July 29, 2020
    Publication date: February 25, 2021
    Applicant: Northwestern University
    Inventors: Evan A. Scott, Sijia Yi, Nicholas Karabin, Xiaomo Li
  • Publication number: 20210030690
    Abstract: The present invention provides novel nanostructures comprising solution of PPSU20. Methods of preparing the novel PPSU nanostructures, and applications of such nanostructures are also provided.
    Type: Application
    Filed: July 29, 2020
    Publication date: February 4, 2021
    Inventors: Evan A. Scott, Fanfan Du, Baofu Qiao, Monica Olvera de la Cruz
  • Publication number: 20200383917
    Abstract: Provided herein are nanocarriers for delivery of immunosuppressive agents. In some embodiments, provided herein are nanocarriers comprising a core comprising a poly(ethylene glycol)-block-poly(propylene sulfide) copolymer and least one therapeutic agent. In some embodiments, the nanocarriers may further comprise a targeting ligand displayed on a surface of the nanocarrier. The at least one therapeutic agent may be an anti-inflammatory agent. The disclosed nanocarriers may be incorporated into pharmaceutical compositions for use in methods of treating an inflammatory condition or preventing transplantation rejection in a subject.
    Type: Application
    Filed: June 3, 2020
    Publication date: December 10, 2020
    Inventors: Evan A. Scott, Guillermo A. Ameer, Jacqueline A. Burke, Sean D. Allen, Sijia Yi
  • Patent number: 10821078
    Abstract: The present invention provides nanomaterials for the specific targeting of immune cells. Methods of treating cardiac disease and inflammatory disease are also described.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: November 3, 2020
    Assignee: Northwestern University
    Inventors: Evan A. Scott, Sijia Yi, Sean D. Allen