Abstract: Systems and methods of associating components of a surgical instrument for navigation-assisted surgery, and controlling the surgical instruments. A first association is generated between the end effector and the navigation array from an input based on an arrangement of tracking elements of the navigation array, and an identification signal. A second association is generated between a power source and the navigation array from a battery signal wirelessly transmitted from the power source that is indicative of current being drawn on the power source. The power source may be controlled based on a position and/or an orientation of the end effector and a pose of a patient tracker. Should the position of the end effector cross a predefined virtual boundary, a control signal wirelessly transmitted to the power source may alter the current being supplied to a motor. An inertial sensor may provide a movement signal used for generating an association.

Abstract: An intraoperative nerve monitoring system for monitoring nerve activity within a trachea of a patient. The intraoperative nerve monitoring system includes an endotracheal (ET) tube assembly, which includes an ET tube partially inserted within a trachea and a surface electrode wrapped about the ET tube. The ET tube is configured to monitor nerve activity when the ET tube is partially inserted within the trachea and is contacting a target tissue and to output a nerve signal. The intraoperative nerve monitoring system also includes a pressure sensor assembly configured to sense an amount of pressure between the surface electrode and the target tissue and a console including an output device configured to output indicators based on the monitored nerve activity and the sensed amount of pressure to facilitate proper placement of the ET tube in the trachea and to indicate nerve activity.

Abstract: The present invention relates to methods of treating or preventing cholesterol related disorders, such as hypercholesterolemia, hyperlipidemia or dyslipidemia, using antibodies against proprotein convertase subtilisin/kexin type 9 (PCSK9). Formulations and methods of producing said formulations are also described.

Abstract: The present invention relates to methods for treating homozygous familial hypercholesterolemia using antibodies against proprotein convertase subtilisin/kexin type 9 (PCSK9).

Abstract: The present invention relates to methods of treating or preventing cholesterol related disorders, such as hypercholesterolemia, hyperlipidemia or dyslipidemia, using antibodies against proprotein convertase subtilisin/kexin type 9 (PCSK9). Formulations and methods of producing said formulations are also described.

Abstract: The present disclosure relates to method of using fluvastatin, alone or in combination with ezetimibe, be used to (1) lower cholesterol level, (2) treat hypercholesterolemia, (3) treat mixed dyslipidemia and/or (4) inhibit cholesterol biosynthesis in patients who experienced muscle-related side effects (MRSE). The present disclosure also relates to a pharmaceutical composition comprising ezetimibe and fluvastatin.