Patents by Inventor Evan D. Kharasch

Evan D. Kharasch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and systems for preparing and preserving a biological sample
    Patent number: 11856945
    Abstract: Methods and systems for preparing and preserving biological samples are disclosed herein. A method comprises contacting a preserving agent with a biological sample to form a mixture, wherein the preserving agent is selected from at least one of a metal-organic framework (MOF) encapsulant or a precursor forming a MOF encapsulant, and wherein the biological sample comprises at least one target analyte. A system comprises a preserving agent selected from at least one of a metal-organic framework (MOF) encapsulant or a precursor forming a MOF encapsulant; and a substrate configured to receive a drop cast mixture of the preserving agent and a biological sample, wherein the biological sample comprises at least one target analyte.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: January 2, 2024
    Assignee: Washington University
    Inventors: Srikanth Singamaneni, Congzhou Wang, Jeremiah J. Morrissey, Evan D. Kharasch
  • METHODS AND SYSTEMS FOR PREPARING AND PRESERVING A BIOLOGICAL SAMPLE
    Publication number: 20200305416
    Abstract: Methods and systems for preparing and preserving biological samples are disclosed herein. A method comprises contacting a preserving agent with a biological sample to form a mixture, wherein the preserving agent is selected from at least one of a metal-organic framework (MOF) encapsulant or a precursor forming a MOF encapsulant, and wherein the biological sample comprises at least one target analyte. A system comprises a preserving agent selected from at least one of a metal-organic framework (MOF) encapsulant or a precursor forming a MOF encapsulant; and a substrate configured to receive a drop cast mixture of the preserving agent and a biological sample, wherein the biological sample comprises at least one target analyte.
    Type: Application
    Filed: April 20, 2018
    Publication date: October 1, 2020
    Applicant: Washington University
    Inventors: Srikanth SINGAMANENI, Congzhou WANG, Jeremiah J. MORRISSEY, Evan D. KHARASCH
  • METAL-ORGANIC FRAMEWORKS AS PROTECTIVE COATINGS AND FOR ENHANCING SENSITIVITY OF BIODIAGNOSTIC CHIPS
    Publication number: 20190360933
    Abstract: Disclosed are diagnostic reagents having metal-organic frameworks and protection and enhancement of diagnostic reagents and materials using metal-organic frameworks.
    Type: Application
    Filed: November 17, 2017
    Publication date: November 28, 2019
    Inventors: Srikanth Singamaneni, Jeremiah J. Morrissey, Evan D. Kharasch, Qisheng Jiang, Congzhou Wang, Jingyi Luan
  • Plasmonic biosensors with built-in artificial antibodies
    Patent number: 10241110
    Abstract: Plasmonic nanotransducers, methods of preparing plasmonic nanotransducers, and methods for label-free detection of target molecules are disclosed. The plasmonic nanotransducers include hollow nanostructure cores and artificial antibodies. The plasmonic nanotransducers are exposed to a biological sample that can contain the specific target molecules. The plasmonic nanotransducers can be analyzed with surface enhanced Raman scattering techniques and/or localized surface plasmon resonance techniques to quantify the amount of the target molecule in the sample.
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: March 26, 2019
    Assignee: Washington University in St. Louis
    Inventors: Srikanth Singamaneni, Limei Tian, Keng-Ku Liu, Abdennour Abbas, Jeremiah J. Morrissey, Evan D. Kharasch
  • BIOPLASMONIC DETECTION OF BIOMARKERS IN BODY FLUIDS USING PEPTIDE RECOGNITION ELEMENTS
    Publication number: 20180031483
    Abstract: Plasmonic nanotransducers and methods for label-free detection of biomarkers are disclosed. The plasmonic nanotransducers include nanostructure cores and peptide aptamers. The plasmonic nanotransducers are exposed to a biological sample that can contain the specific biomarkers and can be analyzed with surface enhanced Raman scattering techniques and/or localized surface plasmon resonance techniques to quantify the amount of the biomarker in the sample.
    Type: Application
    Filed: November 24, 2015
    Publication date: February 1, 2018
    Inventors: Srikanth Singamaneni, Sirimuvva Tadepalli, Jeremiah J. Morrissey, Evan D. Kharasch
  • PLASMONIC BIOSENSORS WITH BUILT-IN ARTIFICIAL ANTIBODIES
    Publication number: 20160282341
    Abstract: Plasmonic nanotransducers, methods of preparing plasmonic nanotransducers, and methods for label-free detection of target molecules are disclosed. The plasmonic nanotransducers include hollow nanostructure cores and artificial antibodies. The plasmonic nanotransducers are exposed to a biological sample that can contain the specific target molecules. The plasmonic nanotransducers can be analyzed with surface enhanced Raman scattering techniques and/or localized surface plasmon resonance techniques to quantify the amount of the target molecule in the sample.
    Type: Application
    Filed: October 17, 2014
    Publication date: September 29, 2016
    Inventors: Srikanth Singamaneni, Limei Tian, Keng-Ku Liu, Abdennour Abbas, Jeremiah J. Morrissey, Evan D. Kharasch
  • BIOPLASMONIC CALLIGRAPHY FOR LABEL-FREE BIODETECTION
    Publication number: 20160257830
    Abstract: The present disclosure relates generally to plasmonic calligraphy and, more specifically, to bioplasmonic calligraphy for label-free biodetection.
    Type: Application
    Filed: March 3, 2016
    Publication date: September 8, 2016
    Inventors: Srikanth Singamaneni, Limei Tian, Sirimuvva Tadepalli, Jeremiah Morrissey, Evan D. Kharasch