Abstract: A recessed light fixture includes an LED module, which includes a single LED package that is configured to generate all light emitted by the recessed light fixture. For example, the LED package can include multiple LEDs mounted to a common substrate. The LED package can be coupled to a heat sink for dissipating heat from the LEDs. The heat sink can include a core member from which fins extend. Each fin can include one or more straight and/or curved portions. A reflector housing may be coupled to the heat sink and configured to receive a reflector. The reflector can have any geometry, such as a bell-shaped geometry including two radii of curvature that join together at an inflection point. An optic coupler can be coupled to the reflector housing and configured to cover electrical connections at the substrate and to guide light emitted by the LED package.

Abstract: A light fixture includes a core member having a top end, a bottom end, and a body extending between the top and bottom ends. The core member includes a solid, single member or modular members. The body includes outer surfaces (“facets”) spaced along an outer perimeter thereof. Each facet can receive one or more light emitting diode (“LED”) packages in various different positions, with different electrical and other configurations. By rearranging and/or reconfiguring the LED packages, the light fixture can have different optical distributions, such as that traditionally provided by metal halide, high intensity discharge, quartz, sodium, incandescent, and fluorescent light sources. Heat pipes extending through the core member dissipate heat from the LEDs. Active cooling modules and/or fins may assist with this heat dissipation. The heat pipes and/or a separate elongated structure extending through the core member can secure the core member to the light fixture.

Abstract: A modular heat sink includes one or more heat sink sections interconnected sequentially to each other to form a polar array. Each heat sink section includes a first connecting part and a second connecting part, where the first connecting part is configured to couple with the second connecting part of another heat sink section. Once assembled, the modular heat sink includes a channel formed substantially through the center of the modular heat sink. Each heat sink section is manufactured using an extrusion process. The assembled modular heat sink has one or more hollow portions within the overall shape that cannot be fabricated in a single extrusion process. One or more LEDs are coupled to the outer surface of the modular heat sink. The modular heat sink, with LEDs coupled thereto, is coupled to a wireway tube and mounted to a post-top light fixture to form an LED luminaire.

Abstract: A recessed light fixture includes an LED module, which includes a single LED package that is configured to generate all light emitted by the recessed light fixture. For example, the LED package can include multiple LEDs mounted to a common substrate. The LED package can be coupled to a heat sink for dissipating heat from the LEDs. The heat sink can include a core member from which fins extend. Each fin can include one or more straight and/or curved portions. A reflector housing may be coupled to the heat sink and configured to receive a reflector. The reflector can have any geometry, such as a bell-shaped geometry including two radii of curvature that join together at an inflection point. An optic coupler can be coupled to the reflector housing and configured to cover electrical connections at the substrate and to guide light emitted by the LED package.

Abstract: A recessed light fixture includes an LED module, which includes a single LED package that is configured to generate all light emitted by the recessed light fixture. For example, the LED package can include multiple LEDs mounted to a common substrate. The LED package can be coupled to a heat sink for dissipating heat from the LEDs. The heat sink can include a core member from which fins extend. Each fin can include one or more straight and/or curved portions. A reflector housing may be coupled to the heat sink and configured to receive a reflector. The reflector can have any geometry, such as a bell-shaped geometry including two radii of curvature that join together at an inflection point. An optic coupler can be coupled to the reflector housing and configured to cover electrical connections at the substrate and to guide light emitted by the LED package.

Abstract: The invention features compositions and methods for in vivo expression analysis. The data presented herein demonstrates that ultrasound-enhanced delivery and/or expression of a composition for expression analysis comprising microbubbles vectors as well as a genetic payload, comprising a “always-on” promoter, a “reference” reporter gene, a “query” promoter and an “answer” reporter gene, enables in vivo analysis of gene expression both without requiring prior preparation (especially genetic modification) of the test subject (animal or patient) and without causing long term or systemic effects on the subject.

Abstract: A light fixture includes a core member having a top end, a bottom end, and a body extending between the top and bottom ends. The core member includes a solid, single member or modular members. The body includes outer surfaces (“facets”) spaced along an outer perimeter thereof. Each facet can receive one or more light emitting diode (“LED”) packages in various different positions, with different electrical and other configurations. By rearranging and/or reconfiguring the LED packages, the light fixture can have different optical distributions, such as that traditionally provided by metal halide, high intensity discharge, quartz, sodium, incandescent, and fluorescent light sources. Heat pipes extending through the core member dissipate heat from the LEDs. Active cooling modules and/or fins may assist with this heat dissipation. The heat pipes and/or a separate elongated structure extending through the core member can secure the core member to the light fixture.

Abstract: A recessed light fixture includes an LED module, which includes a single LED package that is configured to generate all light emitted by the recessed light fixture. For example, the LED package can include multiple LEDs mounted to a common substrate. The LED package can be coupled to a heat sink for dissipating heat from the LEDs. The heat sink can include a core member from which fins extend. Each fin can include one or more straight and/or curved portions. A reflector housing may be coupled to the heat sink and configured to receive a reflector. The reflector can have any geometry, such as a bell-shaped geometry including two radii of curvature that join together at an inflection point. An optic coupler can be coupled to the reflector housing and configured to cover electrical connections at the substrate and to guide light emitted by the LED package.

Abstract: A recessed light fixture includes an LED module, which includes a single LED package that is configured to generate all light emitted by the recessed light fixture. For example, the LED package can include multiple LEDs mounted to a common substrate. The LED package can be coupled to a heat sink for dissipating heat from the LEDs. The heat sink can include a core member from which fins extend. Each fin can include one or more straight and/or curved portions. A reflector housing may be coupled to the heat sink and configured to receive a reflector. The reflector can have any geometry, such as a bell-shaped geometry including two radii of curvature that join together at an inflection point. An optic coupler can be coupled to the reflector housing and configured to cover electrical connections at the substrate and to guide light emitted by the LED package.

Abstract: An apparatus includes a movable member and a valve coupled to the movable member. The movable member is configured to be disposed within a housing of a medical device and has a first end portion and second end portion. A portion of the first end portion is configured to define a portion of a boundary of a gas chamber. The first end portion defines an opening configured to be in fluid communication between the gas chamber and an area outside the gas chamber. The second end portion is configured to be coupled to a needle configured to deliver a medicament into a body. The valve is configured to selectively allow fluid communication between the gas chamber and the area outside the gas chamber through the opening defined by the first end portion of the movable member.

Abstract: An apparatus includes a simulated medicament delivery device and an electronic circuit system coupled to the simulated medicament delivery device. The electronic circuit system is configured to output an electronic output associated with a use of the simulated medicament delivery device.

Abstract: An apparatus includes a label configured to be coupled to a medicament delivery device. The label includes a first surface and a second surface. The first surface is configured to be coupled to an outer surface of the medicament delivery device. The second surface includes a textual indicia. The label further includes an electronic circuit system configured to output an electronic signal.

Abstract: Apparatuses for automatic medicament injection and methods for manufacturing automatic medicament injectors are described herein. In some embodiments, an apparatus includes a housing, a needle, an energy storage member, an actuator, a locking member, and a needle guard. The needle is configured to move between a first position and a second position. In its first position, the needle is contained within the housing. In its second position, at least a portion of the needle extends from the housing. The energy storage member has a first configuration and a second configuration and is configured to produce a force when moving between its first configuration and its second configuration to move the needle from its first position to its second position. The actuator is configured to move the energy storage member from its first configuration to its second configuration.

Abstract: An apparatus includes a housing, a medicament container and an actuator. The actuator includes a release member and an energy storage member having a first position and a second position. In the first position, the energy storage member has a first potential energy. In the second position the energy storage member has a second potential energy. The energy storage member is configured to convert a portion of the first potential energy into kinetic energy when moved from the first position to the second position to move the medicament container within the housing. The energy storage member has a longitudinal axis offset from a longitudinal axis of the medicament container. The release member is configured to selectively deploy the energy storage member from its first position to its second position.

Abstract: An apparatus includes a container defining an internal region configured to contain multiple medicament delivery devices, such as, for example, pen injectors, auto-injectors, inhalers or the like. The container includes an electronic circuit system configured to output a first electronic output associated with a first medicament delivery device contained within the internal region when the first medicament delivery device is removed from the internal region of the container. The electronic circuit system is further configured to output a second electronic output associated with a second medicament delivery device contained within the internal region when the second medicament delivery device is removed from the internal region of the container. The second electronic output is different than the first electronic output. At least one of the first electronic output or the second electronic output is associated with a use instruction.

Abstract: A fluid treatment device is described which includes a cylindrical housing with fluid inlet and outlet means at or adjacent opposite ends. Particulate material for treating fluid flowed through the device, is disposed within the housing, between the inlet and outlet means. A helical baffle is disposed within the housing in the particulate material. The baffle extends axially along the housing and the free edges of its fins are in contact with the housing. The baffle serves to impose a helical path on fluid flowing through the device so that, when the device is mounted with its axis horizontal and with a volume of particulate material less than the volume of the space within the housing, fluid flows through the particulate material most of the time and not entirely along the void as would be the case if the baffle were not present.

Abstract: A water filter cartridge includes a reverse osmosis membrane permeator spirally wound on a central winding tube and surrounded by an impermeable barrier layer which is, in turn, surrounded by a spirally wound prefilter. A post-filter is placed centrally within the winding tube. The cartridge is designed for functional installation in a housing tube fastened and sealed to a valve plate at a first end and closed by a removable end cap at the other, second end. Feed water enters the cartridge through an inlet port in the valve plate at the first end at an outer radius to pass lengthwise in prefilter. Prefiltered water returns from the second end lengthwise through the reverse osmosis permeator to a waste-water outlet port in the valve plate at an intermediate radius. Product water which has permeated through the membrane flows inwardly through holes in the winding tube and into a clearance space surrounding the central post-filter.

Abstract: "A water purification system has a reverse osmosis filtration unit which receives feed water from a feed water valve and separates it into product water and waste water. A reservoir has a movable separator dividing it into a product water chamber for receiving the product water and a control water chamber. The product water is delivered to an outlet connection from the product water chamber or directly from the filtration unit. A regulator is connected to the waste water outlet port of the filtration unit, the control water port of the reservoir, and a drain line. The regulator has a first valve for providing waste water from the filtration unit to the control water port of the reservoir for urging the separator toward the product water chamber. The regulator has a second valve that can rapidly drain water from the control water chamber of the reservoir and rapidly reduce pressure in the control water chamber, thus facilitating the refilling of the product water chamber.