Patents by Inventor Evan Kharasch
Evan Kharasch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11911999Abstract: Fluorescence-based techniques are the cornerstone of modern biomedical optics with applications ranging from bioimaging at various scales (organelle to organism) to detection and quantification of a wide variety of biological species of interest. However, feeble fluorescence signal remains a persistent challenge in meeting the ever-increasing demand to image, detect and quantify biological species of low abundance. Disclosed herein are simple and universal methods based on a flexible and conformal elastomeric film adsorbed with plasmonic nanostructures, referred to as “plasmonic skin” or “plasmonic patch”, that provide large and uniform enhancement of fluorescence on a variety of surfaces, through an “add-on-top” process.Type: GrantFiled: May 6, 2022Date of Patent: February 27, 2024Assignee: Washington UniversityInventors: Srikanth Singamaneni, Jingyi Luan, Jeremiah Morrissey, Evan Kharasch
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Publication number: 20230249441Abstract: Fluorescence-based techniques are the cornerstone of modern biomedical optics with applications ranging from bioimaging at various scales (organelle to organism) to detection and quantification of a wide variety of biological species of interest. However, feeble fluorescence signal remains a persistent challenge in meeting the ever-increasing demand to image, detect and quantify biological species of low abundance. Disclosed herein are simple and universal methods based on a flexible and conformal elastomeric film adsorbed with plasmonic nanostructures, referred to as “plasmonic skin” or “plasmonic patch”, that provide large and uniform enhancement of fluorescence on a variety of surfaces, through an “add-on-top” process.Type: ApplicationFiled: May 6, 2022Publication date: August 10, 2023Inventors: Srikanth Singamaneni, Jingyi Luan, Jeremiah Morrissey, Evan Kharasch
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Patent number: 11519907Abstract: Natural and/or synthetic antibodies for specific proteins are adhered to nanoparticles. The nanoparticles are adhered to a substrate and the substrate is exposed to a sample that may contain the specific proteins. The substrates are then tested with surface enhanced Raman scattering techniques and/or localized surface plasmon resonance techniques to quantify the amount of the specific protein in the sample.Type: GrantFiled: October 19, 2018Date of Patent: December 6, 2022Assignee: Washington UniversityInventors: Srikanth Singamaneni, Evan Kharasch, Jeremiah Morrissey, Chang Hee Lee
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Patent number: 11519906Abstract: Natural and/or synthetic antibodies for specific proteins are adhered to nanoparticles. The nanoparticles are adhered to a substrate and the substrate is exposed to a sample that may contain the specific proteins. The substrates are then tested with surface enhanced Raman scattering techniques and/or localized surface plasmon resonance techniques to quantify the amount of the specific protein in the sample.Type: GrantFiled: July 13, 2018Date of Patent: December 6, 2022Assignee: Washington UniversityInventors: Srikanth Singamaneni, Evan Kharasch, Jeremiah Morrissey, Chang Hee Lee
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Publication number: 20220274381Abstract: Fluorescence-based techniques are the cornerstone of modern biomedical optics with applications ranging from bioimaging at various scales (organelle to organism) to detection and quantification of a wide variety of biological species of interest. However, feeble fluorescence signal remains a persistent challenge in meeting the ever-increasing demand to image, detect and quantify biological species of low abundance. Disclosed herein are simple and universal methods based on a flexible and conformal elastomeric film adsorbed with plasmonic nanostructures, referred to as “plasmonic skin” or “plasmonic patch”, that provide large and uniform enhancement of fluorescence on a variety of surfaces, through an “add-on-top” process.Type: ApplicationFiled: May 6, 2022Publication date: September 1, 2022Inventors: Srikanth Singamaneni, Jingyi Luan, Jeremiah Morrissey, Evan Kharasch
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Patent number: 11351760Abstract: Fluorescence-based techniques are the cornerstone of modern biomedical optics with applications ranging from bioimaging at various scales (organelle to organism) to detection and quantification of a wide variety of biological species of interest. However, feeble fluorescence signal remains a persistent challenge in meeting the ever-increasing demand to image, detect and quantify biological species of low abundance. Disclosed herein are simple and universal methods based on a flexible and conformal elastomeric film adsorbed with plasmonic nanostructures, referred to as “plasmonic skin” or “plasmonic patch”, that provide large and uniform enhancement of fluorescence on a variety of surfaces, through an “add-on-top” process.Type: GrantFiled: November 27, 2018Date of Patent: June 7, 2022Assignee: Washington UniversityInventors: Srikanth Singamaneni, Jingyi Luan, Jeremiah Morrissey, Evan Kharasch
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Patent number: 10830766Abstract: Natural and/or synthetic antibodies for specific proteins are adhered to nanoparticles. The nanoparticles are adhered to a substrate and the substrate is exposed to a sample that may contain the specific proteins. The substrates are then tested with surface enhanced Raman scattering techniques and/or localized surface plasmon resonance techniques to quantify the amount of the specific protein in the sample.Type: GrantFiled: May 22, 2015Date of Patent: November 10, 2020Assignee: Washington UniversityInventors: Srikanth Singamaneni, Evan Kharasch, Jeremiah Morrissey, Chang Hee Lee
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Publication number: 20200326282Abstract: Fluorescence-based techniques are the cornerstone of modern biomedical optics with applications ranging from bioimaging at various scales (organelle to organism) to detection and quantification of a wide variety of biological species of interest. However, feeble fluorescence signal remains a persistent challenge in meeting the ever-increasing demand to image, detect and quantify biological species of low abundance. Disclosed herein are simple and universal methods based on a flexible and conformal elastomeric film adsorbed with plasmonic nanostructures, referred to as “plasmonic skin” or “plasmonic patch”, that provide large and uniform enhancement of fluorescence on a variety of surfaces, through an “add-on-top” process.Type: ApplicationFiled: November 27, 2018Publication date: October 15, 2020Inventors: Srikanth Singamaneni, Jingyi Luan, Jeremiah Morrissey, Evan Kharasch
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Publication number: 20190049440Abstract: Natural and/or synthetic antibodies for specific proteins are adhered to nanoparticles. The nanoparticles are adhered to a substrate and the substrate is exposed to a sample that may contain the specific proteins. The substrates are then tested with surface enhanced Raman scattering techniques and/or localized surface plasmon resonance techniques to quantify the amount of the specific protein in the sample.Type: ApplicationFiled: October 19, 2018Publication date: February 14, 2019Inventors: Srikanth Singamaneni, Evan Kharasch, Jeremiah Morrissey, Chang Hee Lee
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Publication number: 20180321231Abstract: Natural and/or synthetic antibodies for specific proteins are adhered to nanoparticles. The nanoparticles are adhered to a substrate and the substrate is exposed to a sample that may contain the specific proteins. The substrates are then tested with surface enhanced Raman scattering techniques and/or localized surface plasmon resonance techniques to quantify the amount of the specific protein in the sample.Type: ApplicationFiled: July 13, 2018Publication date: November 8, 2018Inventors: Srikanth Singamaneni, Evan Kharasch, Jeremiah Morrissey, Chang Hee Lee
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Patent number: 9410949Abstract: Natural and/or synthetic antibodies for specific proteins are adhered to nanoparticles. The nanoparticles are adhered to a substrate and the substrate is exposed to a sample that may contain the specific proteins. The substrates are then tested with surface enhanced Raman scattering techniques and/or localized surface plasmon resonance techniques to quantify the amount of the specific protein in the sample.Type: GrantFiled: December 2, 2011Date of Patent: August 9, 2016Assignee: Washington University in St. LouisInventors: Srikanth Singamaneni, Evan Kharasch, Jeremiah J. Morrissey, Chang Hee Lee
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Publication number: 20150253317Abstract: Natural and/or synthetic antibodies for specific proteins are adhered to nanoparticles. The nanoparticles are adhered to a substrate and the substrate is exposed to a sample that may contain the specific proteins. The substrates are then tested with surface enhanced Raman scattering techniques and/or localized surface plasmon resonance techniques to quantify the amount of the specific protein in the sample.Type: ApplicationFiled: May 22, 2015Publication date: September 10, 2015Inventors: Srikanth Singamaneni, Evan Kharasch, Jeremiah Morrissey, Chang Hee Lee
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Publication number: 20150253318Abstract: Natural and/or synthetic antibodies for specific proteins are adhered to nanoparticles. The nanoparticles are adhered to a substrate and the substrate is exposed to a sample that may contain the specific proteins. The substrates are then tested with surface enhanced Raman scattering techniques and/or localized surface plasmon resonance techniques to quantify the amount of the specific protein in the sample.Type: ApplicationFiled: May 22, 2015Publication date: September 10, 2015Inventors: Srikanth Singamaneni, Evan Kharasch, Jeremiah Morrissey, Chang Hee Lee
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Publication number: 20120184451Abstract: Natural and/or synthetic antibodies for specific proteins are adhered to nanoparticles. The nanoparticles are adhered to a substrate and the substrate is exposed to a sample that may contain the specific proteins. The substrates are then tested with surface enhanced Raman scattering techniques and/or localized surface plasmon resonance techniques to quantify the amount of the specific protein in the sample.Type: ApplicationFiled: December 2, 2011Publication date: July 19, 2012Applicant: WASHINGTON UNIVERSITYInventors: Srikanth Singamaneni, Evan Kharasch, Jeremiah Morrissey, Chang Hee Lee