Abstract: The present disclosure relates to mTOR inhibitors. Specifically, the embodiments are directed to compounds and compositions inhibiting mTOR, methods of treating diseases mediated by mTOR, and methods of synthesizing these compounds.

Abstract: Provided herein are high energy ion beam generator systems and methods that provide low cost, high performance, robust, consistent, uniform, low gas consumption and high current/high-moderate voltage generation of neutrons and protons. Such systems and methods find use for the commercial-scale generation of neutrons and protons for a wide variety of research, medical, security, and industrial processes.

Abstract: Lipidated oxoadenines of formula (I) are TLR7/8 receptor ligands useful for modulating immune responses. The compounds may have therapeutic application in the treatment of cancer, infectious diseases, allergy, or autoimmune disorders.

Abstract: Provided herein are high energy ion beam generator systems and methods that provide low cost, high performance, robust, consistent, uniform, low gas consumption and high current/high-moderate voltage generation of neutrons and protons. Such systems and methods find use for the commercial-scale generation of neutrons and protons for a wide variety of research, medical, security, and industrial processes.

Abstract: Systems and methods for automatically changing application start state based on device orientation may include receiving a request to open an application, installed on a mobile device, capable of opening using at least two different open behaviors. Then, in response to receiving the request, the method may include (1) using one or more sensors of the mobile device to detect a physical orientation of the mobile device at the time the request is received and (2) opening the application by (i) opening the application using a first open behavior based at least in part on detecting a first orientation of the mobile device or (ii) opening the application using a second open behavior based at least in part on detecting a second orientation of the mobile device. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: Systems, methods, and non-transitory computer-readable media can receive a password from a user. A first password hash is generated based on the password and a first salt. A second password hash is generated based on the first password hash and a second salt. The first salt, the second salt, and the second password hash are transmitted to a third party.

Abstract: Disclosed is a method including receiving visual input comprising a human within a scene, detecting a pose associated with the human using a trained machine learning model that detects human poses to yield a first output, estimating a shape (and optionally a motion) associated with the human using a trained machine learning model associated that detects shape (and optionally motion) to yield a second output, recognizing the scene associated with the visual input using a trained convolutional neural network which determines information about the human and other objects in the scene to yield a third output, and augmenting reality within the scene by leveraging one or more of the first output, the second output, and the third output to place 2D and/or 3D graphics in the scene.

Abstract: The disclosed computer-implemented method may include (1) receiving, in a graphical user interface displayed on a computing device, data corresponding to a search request for a target search result, (2) rendering, from a storage device, a list of search results for the search request in the graphical user interface, (3) detecting, by the computing device, a user-initiated event corresponding to an identification of the target search result during the rendering of the list of search results in the graphical user interface, and (4) interrupting, by the computing device, the rendering of the list of search results in response to detecting the user-initiated event corresponding to the identification of the target search result in the graphical user interface. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: The disclosed computer-implemented method for utilizing machine-readable code in image data for tracking data sharing may include (1) receiving, by a target computing device from a source computing device, image data in a graphical user interface, (2) identifying, by the target computing device, machine-readable code embedded in the image data, and (3) determining, by the target computing device, based on the embedded machine-readable code, one or more tracking metrics associated with sharing the image data. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: Systems and methods for automatically changing application start state based on device orientation may include receiving a request to open an application, installed on a mobile device, capable of opening using at least two different open behaviors. Then, in response to receiving the request, the method may include (1) using one or more sensors of the mobile device to detect a physical orientation of the mobile device at the time the request is received and (2) opening the application by (i) opening the application using a first open behavior based at least in part on detecting a first orientation of the mobile device or (ii) opening the application using a second open behavior based at least in part on detecting a second orientation of the mobile device. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: Systems, methods, and non-transitory computer-readable media can receive a password from a user. A first password hash is generated based on the password and a first salt. A second password hash is generated based on the first password hash and a second salt. The first salt, the second salt, and the second password hash are transmitted to a third party.

Abstract: An audio circuit and associated method for enhanced intelligibility of audio content includes a first means for receiving reproduced audio content, a microphone for providing a microphone output signal in accordance with ambient noise, a second means for enabling the microphone output signal when the reproduced audio content is off, and disabling the microphone output signal when the reproduced audio content is on, and a signal processor, in communication with the first and second means. The signal processor applies a transfer function to the reproduced audio content for increasing gain to the reproduced audio content as a function of increasing amplitude of the microphone output signal, and decreasing gain to the reproduced audio content signal as a function of decreasing amplitude of the microphone output signal, and applies an equalization curve to the audio content to boost frequencies in a range that enhances consonant perception thus increasing speech intelligibility.

Abstract: Methods for processing substrates in twin chamber processing systems having first and second process chambers and shared processing resources are provided herein. In some embodiments, a method may include providing a substrate to the first process chamber of the twin chamber processing system, wherein the first process chamber has a first processing volume that is independent from a second processing volume of the second process chamber; providing one or more processing resources from the shared processing resources to only the first processing volume of the first process chamber; and performing a process on the substrate in the first process chamber.

Abstract: Methods for processing substrates in twin chamber processing systems having first and second process chambers and shared processing resources are provided herein. In some embodiments, a method may include flowing a process gas from a shared gas panel to a processing volume of the first process chamber and to a processing volume of the second process chamber; forming a first plasma in the first processing volume to process the first substrate and a second plasma to process the second substrate; monitoring the first processing volume and the second processing volume to determine if a process endpoint is reached in either volume; and either terminating the first and second plasma simultaneously when a first endpoint is reached; or terminating the first plasma when a first endpoint is reached in the first processing volume while continuing to provide the second plasma in the second processing volume until a second endpoint is reached.

Abstract: Methods and apparatus for twin chamber processing systems are disclosed, and, in some embodiments, may include a first process chamber having a first vacuum pump to maintain a first operating pressure in a first processing volume selectively isolatable by a first gate valve disposed between the first processing volume and the first vacuum pump; a second process chamber having a second vacuum pump for maintaining a second operating pressure in a second processing volume selectively isolatable by a second gate valve disposed between the second processing volume and the second vacuum pump; and a shared vacuum pump coupled to the first and second processing volumes to reduce a pressure in each processing volume below a critical pressure level, wherein the shared vacuum pump can be selectively isolated from any of the first or second process chambers or the first or second vacuum pumps.

Abstract: Methods and apparatus for twin chamber processing systems are disclosed, and, in some embodiments, may include a first process chamber and a second process chamber having independent processing volumes and a plurality of shared resources between the first and second process chambers. In some embodiments, the shared resources include at least one of a shared vacuum pump, a shared gas panel, or a shared heat transfer source.

Abstract: Methods for processing substrates in twin chamber processing systems having first and second process chambers and shared processing resources are provided herein. In some embodiments, a method may include providing a substrate to the first process chamber of the twin chamber processing system, wherein the first process chamber has a first processing volume that is independent from a second processing volume of the second process chamber; providing one or more processing resources from the shared processing resources to only the first processing volume of the first process chamber; and performing a process on the substrate in the first process chamber.

Abstract: Methods for processing substrates in twin chamber processing systems having first and second process chambers and shared processing resources are provided herein. In some embodiments, a method may include flowing a process gas from a shared gas panel to a processing volume of the first process chamber and to a processing volume of the second process chamber; forming a first plasma in the first processing volume to process the first substrate and a second plasma to process the second substrate; monitoring the first processing volume and the second processing volume to determine if a process endpoint is reached in either volume; and either terminating the first and second plasma simultaneously when a first endpoint is reached; or terminating the first plasma when a first endpoint is reached in the first processing volume while continuing to provide the second plasma in the second processing volume until a second endpoint is reached.

Abstract: An audio circuit and associated method for enhanced intelligibility of audio content includes a first means for receiving reproduced audio content, a microphone for providing a microphone output signal in accordance with ambient noise, a second means for enabling the microphone output signal when the reproduced audio content is off, and disabling the microphone output signal when the reproduced audio content is on, and a signal processor, in communication with the first and second means. The signal processor applies a transfer function to the reproduced audio content for increasing gain to the reproduced audio content as a function of increasing amplitude of the microphone output signal, and decreasing gain to the reproduced audio content signal as a function of decreasing amplitude of the microphone output signal, and applies an equalization curve to the audio content to boost frequencies in a range that enhances consonant perception thus increasing speech intelligibility.

Abstract: An improved lifting device for a vacuum transfer system has an elastomeric gasket that provides a contact area which has a large cross-sectional area and is more stable and longer lasting than prior art devices. The elastomeric gasket is typically retained in a housing where vacuum can be supplied to the inside thereof. The Elastomeric gasket, providing a contact surface that is flexible yet strong and having a larger contact area than the lip of a typical suction cup, provides an improved seal between the pick-up device and the article to be moved and a longer period of time before the contact surface needs to be replaced.