Patents by Inventor Evan MACOSKO

Evan MACOSKO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HIGH-RESOLUTION SPATIAL AND QUANTITATIVE DNA ASSESSMENT
    Publication number: 20220389409
    Abstract: The present disclosure relates to compositions and methods for assessing relative DNA levels (e.g., levels of genomic DNA, mtDNA, viral DNA, bacterial DNA, etc.) in a spatially-defined manner across a tissue sample, specifically providing DNA sequence identity and relative abundance information at high-resolution across multiple locations assessed across the tissue sample.
    Type: Application
    Filed: November 9, 2020
    Publication date: December 8, 2022
    Applicants: THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGE, THE GENERAL HOSPITAL CORPORATION
    Inventors: Tongtong Zhao, Fei Chen, Jason Buenrostro, Evan Macosko
  • Method for determination and identification of cell signatures and cell markers
    Patent number: 11225689
    Abstract: The present invention provides for methods of identifying cell types and cell subtypes from a biological sample or population of target cells. The methods further provide for determining cell type or cell subtype signatures. The method further provides for bipolar cell subtypes and markers and cell signatures thereof.
    Type: Grant
    Filed: August 17, 2017
    Date of Patent: January 18, 2022
    Assignees: The Broad Institute, Inc., Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: Karthik Shekhar, Sylvain Lapan, Irene Whitney, Evan Macosko, Steven McCarroll, Constance Cepko, Aviv Regev, Joshua Sanes
  • HIGH-RESOLUTION SPATIAL MACROMOLECULE ABUNDANCE ASSESSMENT
    Publication number: 20210123040
    Abstract: The present disclosure relates to compositions and methods for assessing relative macromolecule abundance (e.g., RNA expression levels) in a spatially-defined manner across a tissue sample, specifically providing deep transcriptomic coverage at high-resolution across multiple locations assessed across the tissue sample.
    Type: Application
    Filed: May 1, 2019
    Publication date: April 29, 2021
    Applicants: THE GENERAL HOSPITAL CORPORATION, THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Evan Macosko, Fei Chen, Sam Rodriques, Robert Stickels, Carly Martin
  • METHOD FOR DETERMINATION AND IDENTIFICATION OF CELL SIGNATURES AND CELL MARKERS
    Publication number: 20180127823
    Abstract: The present invention provides for methods of identifying cell types and cell subtypes from a biological sample or population of target cells. The methods further provide for determining cell type or cell subtype signatures. The method further provides for bipolar cell subtypes and markers and cell signatures thereof.
    Type: Application
    Filed: August 17, 2017
    Publication date: May 10, 2018
    Inventors: Karthik SHEKHAR, Sylvain LAPAN, Irene WHITNEY, Evan MACOSKO, Steven MCCARROLL, Constance CEPKO, Aviv REGEV, Joshua SANES