Patents by Inventor Evan R. Daugharthy

Evan R. Daugharthy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for Detecting and Identifying Genomic Nucleic Acids
    Publication number: 20190032121
    Abstract: The present invention relates to a method of identifying a target genomic nucleic acid sequence including hybridizing a set of probes to the target genomic nucleic acid sequence, wherein the set of probes has a unique associated barcode sequence for identification of the target genomic nucleic acid sequence, wherein each probe of the set includes (1) a complementary sequence complementary to a first strand of the target genomic nucleic acid sequence and (2) the associated barcode sequence or a portion of the associated barcode sequence, sequencing the associated barcode sequence from probes hybridized to the target genomic nucleic acid sequence using a fluorescence-based sequencing method, and identifying the target genomic nucleic acid sequence by the sequenced barcode sequence.
    Type: Application
    Filed: March 17, 2017
    Publication date: January 31, 2019
    Inventors: Evan R. Daugharthy, Sonny C. Nguyen, Chao-ting Wu, George M. Church
  • Method for Generating A Three-Dimensional Nucleic Acid Containing Matrix
    Publication number: 20190024144
    Abstract: Methods of making a three-dimensional matrix of nucleic acids within a cell is provided.
    Type: Application
    Filed: October 11, 2018
    Publication date: January 24, 2019
    Inventors: George M. Church, Je-Hyuk Lee, Richard C. Terry, Evan R. Daugharthy
  • Methods for high-throughput labelling and detection of biological features in situ using microscopy
    Patent number: 10179932
    Abstract: Methods of labelling one or more subcellular components (e.g., an organelle and/or subcellular region) in vivo are provided. Methods of labelling a protein in vivo are provided. Methods of determining a nucleic acid sequence in situ are also provided.
    Type: Grant
    Filed: July 10, 2015
    Date of Patent: January 15, 2019
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Church, Je-Hyuk Lee, Evan R. Daugharthy
  • Method for generating a three-dimensional nucleic acid containing matrix
    Patent number: 10138509
    Abstract: Methods of making a three-dimensional matrix of nucleic acids within a cell is provided.
    Type: Grant
    Filed: February 26, 2014
    Date of Patent: November 27, 2018
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Church, Je-Hyuk Lee, Richard C. Terry, Evan R. Daugharthy
  • Method and Apparatus for Volumetric Imaging of a Three-Dimensional Nucleic Acid Containing Matrix
    Publication number: 20180251833
    Abstract: Methods of volumetric imaging of a three-dimensional matrix of nucleic acids within a cell is provided. An automated apparatus for sequencing and volumetric imaging of a three-dimensional matrix of nucleic acids is provided.
    Type: Application
    Filed: May 2, 2018
    Publication date: September 6, 2018
    Inventors: Evan R. Daugharthy, Richard C. Terry, Je-Hyuk Lee, George M. Church, Benjamin W. Pruitt
  • Method for Generating A Three-Dimensional Nucleic Acid Containing Matrix
    Publication number: 20180051322
    Abstract: Methods of making a three-dimensional matrix of nucleic acids within a cell is provided.
    Type: Application
    Filed: October 18, 2017
    Publication date: February 22, 2018
    Inventors: George M. Church, Je-Hyuk Lee, Richard C. Terry, Evan R. Daugharthy
  • Methods for High-Throughput Labelling and Detection of Biological Features in situ Using Microscopy
    Publication number: 20170159136
    Abstract: Methods of labelling one or more subcellular components (e.g., an organelle and/or subcellular region) in vivo are provided. Methods of labelling a protein in vivo are provided. Methods of determining a nucleic acid sequence in situ are also provided.
    Type: Application
    Filed: July 10, 2015
    Publication date: June 8, 2017
    Applicants: President and Fellows of Harvard College, President and Fellows of Harvard College
    Inventors: George M. Church, Je-Hyuk Lee, Evan R. Daugharthy
  • Method for Generating A Three-Dimensional Nucleic Acid Containing Matrix
    Publication number: 20160024555
    Abstract: Methods of making a three-dimensional matrix of nucleic acids within a cell is provided.
    Type: Application
    Filed: February 26, 2014
    Publication date: January 28, 2016
    Inventors: George M. Church, Je-Hyuk Lee, Richard C. Terry, Evan R. Daugharthy