Abstract: Methods and systems for updating and synchronizing graph-based data across a computer network in a distributed computing environment are disclosed. A system can transmit a digital record comprising a visual representation of one or more sub-graph data structures to a computing device. The digital record can comprise a request for additional information for a sequence of nodes. The system can receive an augmented digital record updated with the additional information from the computing device of the first node. The system can update, based at least on the additional information, at least one node of the sequence of nodes and regenerate the visual representation. The system can identify one or more other nodes of the sequence of nodes to propagate the update to the digital record. The system can propagate the augmented digital record to a computing system of each of the identified one or more other nodes.

Abstract: A system may identify a node in a network graph data structure. The system may identify a matrix identifying quantities of inputs and outputs of a network operation for a networked item. The system may identify a plurality of input nodes connected by edge data structures with the node providing inputs for the network operation. For each of the plurality of input nodes, the system may generate a weight for one or more attributes of one or more technologies used by the input node based on the quantities of the inputs provided by the input node for the network operation. The system may execute a model using the weights for the input nodes and the matrix to generate an emission intensity for each input. The system may calculate an emission of the networked item based at least on the emission intensities of the inputs of the plurality of suppliers.

Abstract: A system receives a request including an identification of a network operation including a transfer of one or more networked items between an entity of a source node and an entity of a destination node and a text description of the one or more networked items. The system identifies one or more sub-graph data structures of nodes corresponding to the source node or the destination node from a network graph data structure and identifies nodes connected to the source and destination nodes. The system retrieves node data from the source node, destination node, and connected nodes. The system generates an embedding of the text description of the items and executes one or more models using the embedding and node data to generate a network operation risk score. The system restricts the network operation by transmitting a message to the computing device when the risk score exceeds a threshold.

Abstract: Systems and methods for reduced hallucination classification by constraining a large language model based on a network graph data structure are disclosed. A server can include a network graph data structure, a classification model, a large language model, and a task agent in communication with the network graph data structure, the classification model, and the large language model. The server can be configured to receive a request comprising an identification of a networked item; execute the task agent to execute the classification model and the large language model to generate a composite set of candidate classification codes; retrieve a description of each candidate classification code of the composite set of candidate classification codes; execute the large language model to generate a selected candidate classification code; and update the network graph data structure based on the selected candidate classification code for the networked item.

Abstract: Methods and systems for updating and synchronizing graph-based data across a computer network in a distributed computing environment are disclosed. A system can create a digital record that corresponds to a task. The system can transmit the digital record to a computing device of at least one entity of a node of a network of nodes with a request for additional information for a sequence of nodes. The system can receive an augmented digital record updated with the additional information from the second computing device associated with a node of the network graph data structure. The system can update a node of the network graph data structure associated with the augmented digital record and regenerate. The system can generate a second digital record comprising a second visual representation generated responsive to the update to the node of the network graph data structure.

Abstract: Techniques are described for detecting compromised nodes in a computing device network using graph-based analysis of network relationships. A network graph stores nodes representing entities and edges representing network operations, each edge including a corresponding operation risk score. Attributes associated with an entity and risk scores of edges connected to the entity's node are aggregated to produce a composite network operation risk score. A model is executed using the entity attributes and the composite risk score to generate an entity risk score. As new network operations occur, new edges and associated risk scores are added to the graph and the composite risk score and entity risk score are updated. When an updated entity risk score exceeds a threshold, an alert is generated identifying the corresponding node as a potentially compromised network node.

Abstract: A surgical self-retaining retractor system includes a self-retaining retractor having first and second tissue engaging members that oppose one another and maintain an opening in an incision. First and second force sensors are respectively coupled to the first and second tissue engaging members such that the force sensors detect force being exerted thereon by tissue when the self-retaining retractor is maintaining an opening through the incision.

Abstract: An online concierge system maintains a taxonomy associating one or more specific items offered by a warehouse with a generic item description. When the online concierge system receives a request to create an order from a user, the online concierge system selects a set of generic item descriptions from previously received orders and displays depictions of each generic item of the set to the user via an interface. In response to the user selecting a generic item description, the online concierge system identifies specific items associated with the selected generic item description from the taxonomy. Different identified specific items are displayed via the interface, for example as a scrollable list, allowing the user to select specific items for an order via the interface after selecting one or more generic item descriptions via the interface.

Abstract: Systems and methods for dynamically modifying a network graph data structure are disclosed. A server can identify a digital record for a networked item, the digital record identifying sub-graph data structures of the network graph data structure, each sub-graph linked to a node of a profile for the networked item and comprising a chain of nodes representing a path of the networked item from a source node to a destination node. The path can represent network operations of the networked item through connected nodes. Each node can represent an entity performing a network operation, and each edge can represent movement of the networked item between nodes. The server can transmit a message containing a link to the digital record, provision a view responsive to selection of the link, receive an indication that the chain does not meet thresholds, and modify the chain to satisfy those thresholds.

Abstract: Systems and methods for dynamically revising a structure of a network graph data structure using a generated view of the network graph data structure are disclosed. A system can receive a request to generate a digital record for a networked item comprising an identification of the networked item. The system can identify a node for a profile for the networked item from a network graph data structure and identify a plurality of attributes of the networked item stored at or with the node. The system can identify one or more sub-graph data structures each linked to the node and comprising a chain of nodes forming a path of instances of the networked item from a source node to a destination node. The system can generate and communicate the digital record and revise a node or edge of the one or more sub-graph data structures based on a user input.

Abstract: The present disclosure provides deuterated compounds and their use as agonists of the M4 muscarinic acetylcholine receptor in the treatment or prevention of various diseases or disorders associated with the M4 receptor.

Abstract: The present disclosure provides deuterated compounds and their use as sodium channel blockers in the treatment or prevention of various diseases or disorders associated with sodium channels.

Abstract: Compounds are provided herein, as well as related preparations, compositions and methods for treating diseases and/or disorders that would benefit from the same such as congenital adrenal hyperplasia (CAH).

Abstract: Coating a bio insulated panel includes milling one or more surfaces of a non-coated bio insulated panel resulting in surface fibers, flame treating the milled panel surface to burn the surface fibers and heat the milled panel surface to dry the panel surface, and coating the milled panel surface while it is dry.

Abstract: Provided are methods of administering a catechol-O-methyltransferase (COMT) inhibitor chosen from opicapone, or a pharmaceutically acceptable salt and/or isotopic variant thereof, to a patient in need thereof wherein the patient is already being administered quinidine or is suffering from a disease or disorder treatable by quinidine.

Abstract: A building insulation and cladding system wherein a plurality of tracks are securable to a building exterior. A plurality of building structures each have a lower edge groove. A plurality of clips are configured to join two adjacent building structures and to secure the building structures to the tracks. The clips engage one of the plurality of tracks and include a rail to be received in the building structure lower edge groove and to support the building structure.

Abstract: Provided are methods related to treating congenital adrenal hyperplasia in a subject in need thereof comprising administering to the subject a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: A vehicle wheel rim including: a tire bed surface having laterally spaced first and second bead seats that are configured to support respective first and second beads of a mating tire; and a rim well laterally positioned between the first and said second bead seats and including a circumferential first step edge; and a first lateral offset region laterally positioned between the first bead seat and the first step edge, with the first step edge extending radially inwardly from the first lateral offset region and configured to provide for lateral alignment registration and/or visual alignment and placement of a first edge of a mating rim strip. The rim strip is a circumferential element that radially outwardly overlaps the rim well and extends laterally inwardly from the first step edge. The first step edge is radially inboard of the first bead seat.

Abstract: An online concierge system maintains a taxonomy associating one or more specific items offered by a warehouse with a generic item description. When the online concierge system receives a request to create an order from a user, the online concierge system selects a set of generic item descriptions from previously received orders and displays depictions of each generic item of the set to the user via an interface. In response to the user selecting a generic item description, the online concierge system identifies specific items associated with the selected generic item description from the taxonomy. Different identified specific items are displayed via the interface, for example as a scrollable list, allowing the user to select specific items for an order via the interface after selecting one or more generic item descriptions via the interface.