Abstract: Coating a bio insulated panel includes milling one or more surfaces of a non-coated bio insulated panel resulting in surface fibers, flame treating the milled panel surface to burn the surface fibers and heat the milled panel surface to dry the panel surface, and coating the milled panel surface while it is dry.

Abstract: Provided are methods of administering a catechol-O-methyltransferase (COMT) inhibitor chosen from opicapone, or a pharmaceutically acceptable salt and/or isotopic variant thereof, to a patient in need thereof wherein the patient is already being administered quinidine or is suffering from a disease or disorder treatable by quinidine.

Abstract: A building insulation and cladding system wherein a plurality of tracks are securable to a building exterior. A plurality of building structures each have a lower edge groove. A plurality of clips are configured to join two adjacent building structures and to secure the building structures to the tracks. The clips engage one of the plurality of tracks and include a rail to be received in the building structure lower edge groove and to support the building structure.

Abstract: Provided are methods related to treating congenital adrenal hyperplasia in a subject in need thereof comprising administering to the subject a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: A vehicle wheel rim including: a tire bed surface having laterally spaced first and second bead seats that are configured to support respective first and second beads of a mating tire; and a rim well laterally positioned between the first and said second bead seats and including a circumferential first step edge; and a first lateral offset region laterally positioned between the first bead seat and the first step edge, with the first step edge extending radially inwardly from the first lateral offset region and configured to provide for lateral alignment registration and/or visual alignment and placement of a first edge of a mating rim strip. The rim strip is a circumferential element that radially outwardly overlaps the rim well and extends laterally inwardly from the first step edge. The first step edge is radially inboard of the first bead seat.

Abstract: An online concierge system maintains a taxonomy associating one or more specific items offered by a warehouse with a generic item description. When the online concierge system receives a request to create an order from a user, the online concierge system selects a set of generic item descriptions from previously received orders and displays depictions of each generic item of the set to the user via an interface. In response to the user selecting a generic item description, the online concierge system identifies specific items associated with the selected generic item description from the taxonomy. Different identified specific items are displayed via the interface, for example as a scrollable list, allowing the user to select specific items for an order via the interface after selecting one or more generic item descriptions via the interface.

Abstract: A production plan for producing cannabis in a facility comprising a building module comprising five growth chambers of substantially equal size and a GMP processing area comprises a system of concurrent cyclic processes (SCCPs) for carrying out cannabis processing steps of hardening; growth, wet hanging, in-process quality control, transfer to GMP drying; in-process quality control; trimming; curing, and grading/packing. The SCCPs is based upon a minimum cycle time (MCT) defined as MCT=FP/5, where FP is a flowering period for a selected cannabis species, and 5 is the number of growth chambers in which the cannabis species will be grown. A cannabis production facility comprises a building module having five growth chambers of substantially equal size, a GMP processing area and a production plan. A method is provided for designing a cannabis production facility for assessing the feasibility thereof at a concept stage.

Abstract: A rim for a vehicle wheel, the rim comprising: a circumferential tire bed surface, the tire bed surface comprising: a circumferential first bead seat and a circumferential second bead seat laterally spaced from said first bead seat, said first bead seat configured to support a first bead of a mating tire and said second bead seat configured to support a second bead of said mating tire; a circumferential rim well laterally positioned between said first bead seat and said second bead seat; wherein said rim well comprises a circumferential first step edge laterally inwardly offset from said first bead seat and a circumferential first spacer region laterally positioned between said first bead seat and said first step edge; at least a portion of said first spacer portion is radially inboard of said first bead; said first step edge extending radially inwardly from said first spacer region; wherein said first step edge is configured to provide for lateral alignment registration and/or visual alignment and placement

Abstract: Compounds are provided herein, as well as related preparations, compositions and methods for treating diseases and/or disorders that would benefit from the same such as congenital adrenal hyperplasia (CAH).

Abstract: A rim sealing strip comprising: a circumferentially elongated rim strip having a radially outwardly facing outboard surface, a radially inwardly facing inboard surface, a first lateral edge and a second lateral edge laterally spaced from the first lateral edge; where the rim strip includes an overall lateral width between the first lateral edge and the second lateral edge and a radial thickness between the outboard surface and the inboard surface; and where the radial thickness is variable across the lateral width to include a first lateral region having a first radial thickness and a second lateral region having a second radial thickness, where the first radial thickness is thicker than the second radial thickness.

Abstract: Provided are methods of administering a catechol-O-methyltransferase (COMT) inhibitor chosen from opicapone, or a pharmaceutically acceptable salt and/or isotopic variant thereof, to a patient in need thereof wherein the patient is already being administered quinidine or is suffering from a disease or disorder treatable by quinidine.

Abstract: A device for generally providing an unobtrusive and protective padded area for placement on a basketball hoop rim in a wrapped assembly. The device comprising a pad having a first side and a second side opposed the first side defining a thickness. The pad including a plurality of apertures having a size and spaced for the receipt of a net hook of the rim and at least one fastener configured to secure the device around the rim.

Abstract: Provided are methods of administering a catechol-O-methyltransferase (COMT) inhibitor chosen from opicapone, or a pharmaceutically acceptable salt and/or isotopic variant thereof, to a patient in need thereof wherein the patient is also being administered a CYP2C8 substrate, such as repaglinide.

Abstract: A handlebar-grip system and apparatus comprising: a handlebar, the handlebar comprising: a center portion, a handle attached to a first end of the center portion, the handle comprising: a handle outboard and extending along an axial axis; a handle engaging geometry located on the handle outboard end, the handle engaging geometry is noncircular about the axial axis; a grip configured to slide onto the handle outboard end, the grip comprising: a grip central opening; a grip engaging geometry located in the grip central opening; a first portion that is circumferentially offset and axially coincident relative to a second portion thereof, where the first portion has a greater radial thickness than the second portion; where, with the handle positioned within the grip central opening, the grip is circumferentially keyed to the handle to limit rotation therebetween about the axial axis.

Abstract: A device for generally providing an unobtrusive and protective padded area for placement on a basketball hoop rim in a wrapped assembly. The device comprising a pad having a first side and a second side opposed the first side defining a thickness. The pad including a plurality of apertures having a size and spaced for the receipt of a net hook of the rim and at least one fastener configured to secure the device around the rim.

Abstract: A rim sealing strip comprising: a circumferentially elongated rim strip having a radially outwardly facing outboard surface, a radially inwardly facing inboard surface, a first lateral edge and a second lateral edge laterally spaced from the first lateral edge; where the rim strip includes an overall lateral width between the first lateral edge and the second lateral edge and a radial thickness between the outboard surface and the inboard surface; and where the radial thickness is variable across the lateral width to include a first lateral region having a first radial thickness and a second lateral region having a second radial thickness, where the first radial thickness is thicker than the second radial thickness.

Abstract: A wavelength selective bolometer includes a substrate configured to serve as a foundation for the apparatus and a thermal isolation gap established between the substrate and subsequent solid material layers. A conducting ground plane layer is disposed above the thermal isolation gap, and a first dielectric layer is mated to a top surface of the conducting ground plane. A temperature sensing material layer is mated to a top surface of the first dielectric layer, and a plurality of interconnects is placed in electrical communication with the temperature sensing material layer. A second dielectric layer is mated to a top surface of the temperature sensing material, and at least one conductive element is mated to a top surface of the second dielectric layer. The dimensions of the conductive element and other variables are chosen to achieve resonant absorption of selected wavelengths of radiation incident thereupon.

Abstract: A handlebar and grip system comprising: a handlebar, the handlebar comprising: a center portion; a right handle attached to a first end of the center portion, the right handle comprising: a right handle outboard end; a right handle engaging geometry located on the right handle outboard end a left handle attached to the second end of the center portion, the left handle comprising: a left handle outboard end; a left handle engaging geometry located on the left handle outboard end; a right grip configured to slide onto the outboard end of the right handle, the right grip comprising: a right grip central opening; a right grip engaging geometry located in the right grip central opening; a left grip configured to slide onto the outboard end of the left handle; a left grip central opening; a left grip engaging geometry located in the left grip central opening; where the right grip engaging geometry is configured to engage with the right handle engaging geometry such that the right grip will generally be prevented fr

Abstract: A drawbar pin-retention assembly for use with a drawbar mechanism has a swinging drawbar, a support housing, and a device configured to prevent the swinging of the drawbar, the device having at least one drawbar pin. The pin-retention assembly includes a hanger bracket having a body portion and a pair of overhanging arms and a retaining bracket mounted on the hanger bracket with hinge tabs and pivotable about a pivot axis to move between a pin-retaining position and a pin-removal position. When the retaining bracket is pivoted to its pin-retaining position, a strap is positioned over the drawbar pin. Outward movement of the pin causes it to contact a forward portion of the strap forward of the pivot axis causing the retaining bracket to contact the hanger bracket thereby preventing pivoting of the retaining bracket in a first direction. The retaining bracket pivots by gravity to the pin-retention position.

Abstract: A drawbar pin-retention assembly for use with a drawbar mechanism has a swinging drawbar, a support housing, and a device configured to prevent the swinging of the drawbar, the device having at least one drawbar pin. The pin-retention assembly includes a hanger bracket having a body portion and a pair of overhanging arms and a retaining bracket mounted on the hanger bracket with hinge tabs and pivotable about a pivot axis to move between a pin-retaining position and a pin-removal position. When the retaining bracket is pivoted to its pin-retaining position, a strap is positioned over the drawbar pin. Outward movement of the pin causes it to contact a forward portion of the strap forward of the pivot axis causing the retaining bracket to contact the hanger bracket thereby preventing pivoting of the retaining bracket in a first direction. The retaining bracket pivots by gravity to the pin-retention position.