Patents by Inventor Evan W. ROGERS

Evan W. ROGERS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

MACROCYCLIC COMPOUNDS AND USE AS KINASE INHIBITORS

Publication number: 20250074920

Abstract: The present disclosure relates to macrocyclic compounds, pharmaceutical compositions containing macrocyclic compounds, and methods of using macrocyclic compounds to treat disease, such as autoimmune disease.

Type: Application

Filed: January 3, 2023

Publication date: March 6, 2025

Inventors: Jingrong Jean CUI, Eugene Yuanjin RUI, Evan W. ROGERS, Dayong ZHAI
MACROCYCLES AND THEIR USE

Publication number: 20240182487

Abstract: The present disclosure relates to macrocyclic compounds, pharmaceutical compositions containing macrocyclic compounds, and methods of using macrocyclic compounds to treat disease, such as cancer.

Type: Application

Filed: December 16, 2021

Publication date: June 6, 2024

Inventors: Jingrong J. CUI, Eugene RUI, Evan W. ROGERS
CHIRAL DIARYL MACROCYCLES AND USES THEREOF

Publication number: 20230346786

Abstract: This disclosure relates to the use of certain diaryl macrocycle compounds, specifically (7S13R)-11-fluoro-7,13-di-methyl-6,7,13,14-tetrahydro-1,15-ethenopyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one in the treatment of disease in mammals. This disclosure also relates to compositions including such compounds, and to methods of using such compositions in the treatment of diseases in mammals, especially in humans.

Type: Application

Filed: August 15, 2022

Publication date: November 2, 2023

Inventors: Jingrong J. CUI, Yishan LI, Evan W. ROGERS, Dayong ZHAI, Wei DENG, Zhongdong HUANG
POLYMORPHS OF A MACROCYCLIC KINASE INHIBITOR

Publication number: 20220411439

Abstract: This disclosure relates to polymorphs of (3aR,11S,20aS)-7-fluoro-11-methyl-2,3,3a,12,13,20a-hexahydro-1H,5H-17,19-(metheno)cyclopenta[5,6][1,4]oxazino[3,4-i]pyrazolo[4,3-f]pyrido[3,2-l][1,4,8,10]oxatriazacyclotridecin-14(11H)-one that are useful in the treatment of disease, such as cancer, in mammals. This disclosure also relates to compositions including such polymorphs, and to methods of using such compositions in the treatment of diseases, such as cancer, in mammals, especially in humans.

Type: Application

Filed: June 16, 2020

Publication date: December 29, 2022

Inventors: Wei DENG, Evan W. ROGERS, Yuelie LU, Han ZHANG, Jing LIU
MACROCYCLIC KINASE INHIBITORS AND THEIR USE

Publication number: 20210087206

Abstract: The present disclosure relates to certain chiral diaryl macrocyclic derivatives, pharmaceutical compositions containing them, and methods of using them to treat cancer, pain, neurological diseases, autoimmune diseases, and inflammation.

Type: Application

Filed: December 18, 2018

Publication date: March 25, 2021

Inventors: Evan W. ROGERS, Jane UNG, Han ZHANG, Jeffrey WHITTEN, Dayong ZHAI, Wei DENG, Jingrong Jean CUI
CHIRAL DIARYL MACROCYCLES AND USES THEREOF

Publication number: 20210030756

Abstract: This disclosure relates to the use of certain diaryl macrocycle compounds, specifically (7S13R)-11-fluoro-7,13-di-methyl-6,7,13,14-tetrahydro-1,15-ethenopyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one in the treatment of disease in mammals. This disclosure also relates to compositions including such compounds, and to methods of using such compositions in the treatment of diseases in mammals, especially in humans.

Type: Application

Filed: August 20, 2020

Publication date: February 4, 2021

Inventors: Jingrong J. CUI, Yishan LI, Evan W. ROGERS, Dayong ZHAI, Wei DENG, Zhongdong HUANG
MACROCYCLIC COMPOUNDS AND USES THEREOF

Publication number: 20200157119

Abstract: The present disclosure relates to certain macrocyclic compounds that inhibit SRC and MET, and/or CSF1R, pharmaceutical compositions containing such compounds, and methods of using such compounds to treat cancer.

Type: Application

Filed: July 26, 2018

Publication date: May 21, 2020

Inventors: Jingrong Jean CUI, Evan W. ROGERS, Jane UNG, Jeffrey Whitten, Dayong Zhai, Wei DENG, Xin ZHANG, Zhongdong HUANG, Jing LIU, Han ZHANG
CHIRAL DIARYL MACROCYCLES AS MODULATORS OF PROTEIN KINASES

Publication number: 20190284209

Abstract: The present disclosure relates to certain chiral diaryl macrocyclic derivatives, pharmaceutical compositions containing them, and methods of using them to treat cancer, pain, neurological diseases, autoimmune diseases, and inflammation.

Type: Application

Filed: May 29, 2019

Publication date: September 19, 2019

Inventors: Jingrong J. CUI, Yishan LI, Evan W. ROGERS, Dayong ZHAI, Wei DENG, Jane UNG
MACROCYCLE KINASE INHIBITORS

Publication number: 20190169208

Abstract: The present disclosure relates to certain macrocyclic kinase inhibitors, pharmaceutical compositions containing the same, and methods of using the same to treat disease.

Type: Application

Filed: July 27, 2017

Publication date: June 6, 2019

Inventors: Jingrong Jean CUI, Yishan LI, Evan W. ROGERS, Dayong ZHAI, Jane UNG
CHIRAL DIARYL MACROCYCLES AND USES THEREOF

Publication number: 20180325901

Abstract: This disclosure relates to the use of certain diaryl macrocycle compounds, specifically (7S13R)-11-fluoro-7,13-di-methyl-6,7,13,14-tetrahydro-1,15-ethenopyrazolo [4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one in the treatment of disease in mammals. This disclosure also relates to compositions including such compounds, and to methods of using such compositions in the treatment of diseases in mammals, especially in humans.

Type: Application

Filed: July 20, 2016

Publication date: November 15, 2018

Inventors: Jingrong J. CUI, Yishan LI, Evan W. ROGERS, Dayong ZHAI, Wei DENG, Zhongdong HUANG
DIARYL MACROCYCLE POLYMORPH

Publication number: 20180194777

Abstract: This disclosure relates to polymorphs of (7S,13R)-11-fluoro-7,13-dimethyl-6,7,13,14-tetrahydro-1,15-ethenopyrazolo[4,3-f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)-one that are useful in the treatment of disease, such as cancer, in mammals. This disclosure also relates to compositions including such polymorphs, and to methods of using such compositions in the treatment of diseases, such as cancer, in mammals, especially in humans.

Type: Application

Filed: July 5, 2016

Publication date: July 12, 2018

Inventors: Jingrong J. CUI, Evan W. ROGERS
CHIRAL DIARYL MACROCYCLES AS MODULATORS OF PROTEIN KINASES

Publication number: 20180186813

Abstract: The present disclosure relates to certain chiral diaryl macrocyclic derivatives, pharmaceutical compositions containing them, and methods of using them to treat cancer, pain, neurological diseases, autoimmune diseases, and inflammation.

Type: Application

Filed: June 30, 2016

Publication date: July 5, 2018

Inventors: Jingrong J. CUI, Yishan LI, Evan W. ROGERS, Dayong ZHAI, Wei DENG, Jane UNG
DIARYL MACROCYCLES AS MODULATORS OF PROTEIN KINASES

Publication number: 20170334929

Abstract: The present invention relates to certain diaryl macrocyclic compounds, pharmaceutical compositions containing them, and methods of using them, including methods for treating cancer, pain, neurological diseases, autoimmune diseases, and inflammation.

Type: Application

Filed: May 31, 2017

Publication date: November 23, 2017

Inventors: Jingrong Jean CUI, Yishan LI, Evan W. ROGERS, Dayong ZHAI
DIARYL MACROCYCLES AS MODULATORS OF PROTEIN KINASES

Publication number: 20170002023

Abstract: The present invention relates to certain diaryl macrocyclic compounds, pharmaceutical compositions containing them, and methods of using them, including methods for treating cancer, pain, neurological diseases, autoimmune diseases, and inflammation.

Type: Application

Filed: January 23, 2015

Publication date: January 5, 2017

Applicant: TP Therapeutics, Inc.

Inventors: Jingrong Jean CUI, Yishan LI, Evan W. ROGERS, Dayong ZHAI