Patents by Inventor Evangelia Chnari
Evangelia Chnari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11786637Abstract: Methods and compositions for preparing and priming a tissue graft for an accelerated therapeutic effect are provided herein. In one embodiment, the method includes obtaining a tissue containing viable cells from a donor, wherein the viable cells are endogenous to the tissue and remain resident in the tissue; and priming the viable cells with one or more stimuli comprising simulated hypoxia to produce a primed tissue, wherein when grafted to a recipient the primed tissue provides a benefit compared to non-primed tissue.Type: GrantFiled: March 1, 2021Date of Patent: October 17, 2023Assignee: Musculoskeletal Transplant FoundationInventors: Eric Semler, Mark Spilker, Kevin Wu, Yen-Chen Huang, Evangelia Chnari, Jeffrey Cartmell, Morris Jacobs, Alison Ling, Moon Hae Sunwoo
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Publication number: 20230072250Abstract: Compositions including a first soft tissue-derived matrix and a second soft tissue-derived matrix are provided, as well as methods of making such compositions. In some embodiments, the composition comprises delipidated, decellularized adipose tissue-derived matrix and delipidated, decellularized fascial tissue-derived matrix, which may be combined in various proportions. Such adipose-fascia matrix compositions provide improved volume retention when implanted into a patient. The composition may further include exogenous cells or other substances, and/or a carrier. The composition is suitable for use in plastic surgery procedures, including reconstructive or cosmetic surgery procedures, as well as procedures for wound treatment and tissue regeneration.Type: ApplicationFiled: November 11, 2022Publication date: March 9, 2023Inventors: Benjamin Schilling, Andrew Madans, Abigail Phipps, Thomas Tylutki, Todd Nilsen, Yen-Chen Huang, Evangelia Chnari
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Publication number: 20230068127Abstract: Diversified grafts suitable for use in repair and reconstruction procedures are provided. Some diversified grafts comprise two or more heterogenous features which form regions having different preferred properties. A diversified graft useful for pre-pectoral breast reconstruction, meshing is provided on an upper pole of the diversified graft and a plurality of slits arranged in particular patterns is provided on a lower pole of the graft, whereby the upper pole has a greater expansion ability and the lower pole has lesser degree of expansion ability but maintains greater load bearing capacity which is necessary to support the lower pole of the breast undergoing reconstruction, while allowing for fluid egress. In other embodiments, the diversified graft comprises two or more components which are combined by attaching them to each other to form a larger graft of the required size. The components may be smaller pieces of the same material or different materials.Type: ApplicationFiled: August 23, 2022Publication date: March 2, 2023Inventors: Marc Long, Evangelia Chnari, Jeffrey Cartmell
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Publication number: 20230057906Abstract: Multiple component grafts are provided for treatment of tissue defects and comprise two or more components, each of which is a tissue-derived matrix and at least two of which are derived from different types of tissue. For example, a first component may be a matrix derived from cartilage tissue such as cartilage fibers with or without viable cells, cartilage particles with or without viable cells, or combinations of any two or more such cartilage-derived matrices. A second component may be a matrix derived from bone tissue such as mineralized or demineralized cortical bone fibers, viable cancellous bone matrix (e.g., cryopreserved or lyophilized chips, particulates, powder, sheets, putty, flowable fluid, etc.), demineralized or demineralized cancellous bone matrix (chips, particulates, powder, sheets, putty, flowable fluid, etc.), or combinations of any two or more of such bone-derived matrices. Also provided are methods for making and using such multiple component grafts.Type: ApplicationFiled: January 14, 2021Publication date: February 23, 2023Inventors: Marc Long, Eric J. Semler, Mat Citro, Evangelia Chnari
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Patent number: 11524093Abstract: Compositions including a first soft tissue-derived matrix and a second soft tissue-derived matrix are provided, as well as methods of making such compositions. In some embodiments, the composition comprises dilapidated, decellularized adipose tissue-derived matrix and dilapidated, decellularized fascial tissue-derived matrix, which may be combined in various proportions. Such adipose-fascia matrix compositions provide improved volume retention when implanted into a patient. The composition may further include exogenous cells or other substances, and/or a carrier. The composition is suitable for use in plastic surgery procedures, including reconstructive or cosmetic surgery procedures, as well as procedures for wound treatment and tissue regeneration.Type: GrantFiled: December 22, 2020Date of Patent: December 13, 2022Assignee: Musculoskeletal Transplant FoundationInventors: Benjamin Schilling, Andrew Madans, Abigail Phipps, Thomas Tylutki, Todd Nilsen, Yen-Chen Huang, Evangelia Chnari
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Publication number: 20220280693Abstract: Tissue derived porous matrices for treating wounds are provided, as well as methods for making and using them. The tissue derived porous matrices comprise processed tissue of any of several types, such as dermis, adipose, etc., and have a plurality of interconnected pores which allow fluid flow through the matrices. The tissue derived matrices are biocompatible resorbable matrices which remodel with native tissue and facilitate and enhance cell infiltration and tissue ingrowth into the matrices during the wound healing process, thereby enhancing wound healing and tissue remodeling when implanted into a patient. The tissue derived matrices are useful with reduced or negative pressure wound healing methods and systems, without the need to repeatedly revisit the treatment site and remove previously implanted matrices.Type: ApplicationFiled: May 8, 2020Publication date: September 8, 2022Inventors: Christopher M. Nichols, Abigail Phipps, Andrew Madans, Kevin Wu, Evangelia Chnari
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Publication number: 20210178022Abstract: Methods and compositions for preparing and priming a tissue graft for an accelerated therapeutic effect are provided herein. In one embodiment, the method includes obtaining a tissue containing viable cells from a donor, wherein the viable cells are endogenous to the tissue and remain resident in the tissue; and priming the viable cells with one or more stimuli comprising simulated hypoxia to produce a primed tissue, wherein when grafted to a recipient the primed tissue provides a benefit compared to non-primed tissue.Type: ApplicationFiled: March 1, 2021Publication date: June 17, 2021Inventors: Eric Semler, Mark Spilker, Kevin Wu, Yen-Chen Huang, Evangelia Chnari, Jeffrey Cartmell, Morris Jacobs, Alison Ling, Moon Hae Sunwoo
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Publication number: 20210106725Abstract: Compositions including a first soft tissue-derived matrix and a second soft tissue-derived matrix are provided, as well as methods of making such compositions. In some embodiments, the composition comprises dilapidated, decellularized adipose tissue-derived matrix and dilapidated, decellularized fascial tissue-derived matrix, which may be combined in various proportions. Such adipose-fascia matrix compositions provide improved volume retention when implanted into a patient. The composition may further include exogenous cells or other substances, and/or a carrier. The composition is suitable for use inplastic surgery procedures, including reconstructive or cosmetic surgery procedures, as well as procedures for wound treatment and tissue regeneration.Type: ApplicationFiled: December 22, 2020Publication date: April 15, 2021Inventors: Benjamin Schilling, Andrew Madans, Abigail Phipps, Thomas Tylutki, Todd Nilsen, Yen-Chen Huang, Evangelia Chnari
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Patent number: 10973953Abstract: Methods and compositions for preparing and priming a tissue graft for an accelerated therapeutic effect are provided herein. In one embodiment, the method includes obtaining a tissue containing viable cells from a donor, wherein the viable cells are endogenous to the tissue and remain resident in the tissue; and priming the viable cells with one or more stimuli to produce a primed tissue, wherein when grafted to a recipient the primed tissue provides a benefit compared to non-primed tissue.Type: GrantFiled: August 17, 2017Date of Patent: April 13, 2021Assignee: Musculoskeletal Transplant FoundationInventors: Eric Semler, Mark Spilker, Kevin Wu, Yen-Chen Huang, Evangelia Chnari, Jeffrey Cartmell, Morris Jacobs, Alison Ling, Moon Hae Sunwoo
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Patent number: 10945831Abstract: A dermal tissue allograft includes a dermal matrix having a profile including first and second vertices, a first imaginary axis extending between the first and second vertices, a first peripheral edge extending along a continuous path from the first vertex to the second vertex on a first side of the first imaginary axis, and a second peripheral edge extending along a continuous path from the first vertex to the second vertex on a second side of the first imaginary axis. The first peripheral edge includes an apogee, a convex portion, and a concave portion. The convex and concave portions meet at a transition point located on the first peripheral edge between its apogee and the second vertex. The second peripheral edge includes an apogee and is convex. The second perpendicular distance is greater than the first perpendicular distance. The dermal matrix has a substantially uniform thickness across its profile.Type: GrantFiled: June 3, 2016Date of Patent: March 16, 2021Assignees: Musculoskeletal Transplant Foundation, The Methodist HospitalInventors: Antonio M. Bunce, Todd J. Nilsen, Evangelia Chnari, Aldona J. Spiegel, Michael Locarno, Gregory P. Adams
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Patent number: 10912864Abstract: Compositions including a first soft tissue-derived matrix and a second soft tissue-derived matrix are provided, as well as methods of making such compositions. In some embodiments, the composition comprises delipidated, decellularized adipose tissue-derived matrix and delipidated, decellularized fascial tissue-derived matrix, which may be combined in various proportions. Such adipose-fascia matrix compositions provide improved volume retention when implanted into a patient. The composition may further include exogenous cells or other substances, and/or a carrier. The composition is suitable for use inplastic surgery procedures, including reconstructive or cosmetic surgery procedures, as well as procedures for wound treatment and tissue regeneration.Type: GrantFiled: May 31, 2019Date of Patent: February 9, 2021Assignee: Musculoskeletal Transplant FoundationInventors: Benjamin Schilling, Andrew Madans, Abigail Phipps, Thomas Tylutki, Todd Nilsen, Yen-Chen Huang, Evangelia Chnari
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Publication number: 20200376163Abstract: The present invention relates generally to tissue forms useful as grafts or implants and derived from membranous tissue. The tissue forms may contain viable endogenous cells. The tissue forms may be sheets or mini sheets, each having quadrilateral, circular, polygonal, or irregular shapes. The sheet tissue form may have a generally quadrilateral shape, with an average length of about 1 to about 20 centimeters and an average width of about 1 to about 20 centimeters. The mini sheet tissue form may have a generally quadrilateral shape, with an average length of about 0.5 to about 9 millimeters and an average width of about 0.5 to about 9 millimeters. A mixture of the mini sheet tissue form and a liquid, such as cryopreservation fluid, saline or buffer solution, is flowable, which means the mixture will pass through a luer-slip tip syringe, or a gauge needle.Type: ApplicationFiled: August 19, 2020Publication date: December 3, 2020Inventors: Kevin Wu, Abigail Phipps, Anouska Dasgupta, Evangelia Chnari, Eric Semler
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Publication number: 20190298885Abstract: Compositions including a first soft tissue-derived matrix and a second soft tissue-derived matrix are provided, as well as methods of making such compositions. In some embodiments, the composition comprises delipidated, decellularized adipose tissue-derived matrix and delipidated, decellularized fascial tissue-derived matrix, which may be combined in various proportions. Such adipose-fascia matrix compositions provide improved volume retention when implanted into a patient. The composition may further include exogenous cells or other substances, and/or a carrier. The composition is suitable for use inplastic surgery procedures, including reconstructive or cosmetic surgery procedures, as well as procedures for wound treatment and tissue regeneration.Type: ApplicationFiled: May 31, 2019Publication date: October 3, 2019Inventors: Benjamin Schilling, Andrew Madans, Abigail Phipps, Thomas Tylutki, Todd Nilsen, Yen-Chen Huang, Evangelia Chnari
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Publication number: 20170348088Abstract: A dermal tissue allograft includes a dermal matrix having a profile including first and second vertices, a first imaginary axis extending between the first and second vertices, a first peripheral edge extending along a continuous path from the first vertex to the second vertex on a first side of the first imaginary axis, and a second peripheral edge extending along a continuous path from the first vertex to the second vertex on a second side of the first imaginary axis. The first peripheral edge includes an apogee, a convex portion, and a concave portion. The convex and concave portions meet at a transition point located on the first peripheral edge between its apogee and the second vertex. The second peripheral edge includes an apogee and is convex. The second perpendicular distance is greater than the first perpendicular distance. The dermal matrix has a substantially uniform thickness across its profile.Type: ApplicationFiled: June 3, 2016Publication date: December 7, 2017Applicant: MUSCULOSKELETAL TRANSPLANT FOUNDATIONInventors: Antonio M. Bunce, Todd J. Nilsen, Evangelia Chnari, Aldona J. Spiegel, Michael Locarno, Gregory P. Adams
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Publication number: 20170021058Abstract: A composition including delipidated, decellularized adipose tissue and delipidated, decellularized fascial tissue is provided. The composition may further include exogenous tissuegenic cells, an exogenous growth-inductive substance, and/or a carrier. The composition is suitable for implantation into a living body in plastic surgery procedures, including reconstructive or cosmetic surgery procedures, wound care procedures or other procedures of regenerative medicine. A method of preparing an acellular soft tissue-derived matrix from adipose tissue and fascial tissue is also provided.Type: ApplicationFiled: July 22, 2016Publication date: January 26, 2017Applicant: MUSCULOSKELETAL TRANSPLANT FOUNDATIONInventors: Yen-Chen Huang, Asia Ivery, Bryan Choi, Benjamin Schilling, Manh-Dan Ngo, Evangelia Chnari, Todd Nilsen
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Patent number: 8883210Abstract: The disclosure provides implants containing a plurality of particles containing at least one population of viable tissuegenic cells adherent to and resident in the growth-conductive matrix or at least viable population of tissuegenic cells caused to be in contact with the growth-conductive matrix; methods to fabricate implants; methods of fabricating the implants; and use of the implants in tissue repair.Type: GrantFiled: May 16, 2011Date of Patent: November 11, 2014Assignee: Musculoskeletal Transplant FoundationInventors: Katherine Gomes Truncale, Arthur A. Gertzman, Yen-Chen Huang, Eric Semler, Evangelia Chnari, Anouska Dasgupta, Judith Yannariello-Brown, Terri Riley
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Patent number: 8834928Abstract: The disclosure provides implants containing a plurality of particles containing at least one population of viable tissuegenic cells adherent to and resident in the growth-conductive matrix or at least viable population of tissuegenic cells caused to be in contact with the growth-conductive matrix; methods to fabricate implants; methods of fabricating the implants; and use of the implants in tissue repair.Type: GrantFiled: July 23, 2013Date of Patent: September 16, 2014Assignee: Musculoskeletal Transplant FoundationInventors: Katherine Gomes Truncale, Arthur A. Gertzman, Yen-Chen Huang, Eric Semler, Evangelia Chnari, Anouska Dasgupta, Judith Yannariello-Brown, Terri Riley