Patents by Inventor Evangelos Karavas

Evangelos Karavas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190274965
    Abstract: The present invention relates to a stable pharmaceutical formulation of solid dosage forms for oral administration comprising a therapeutically effective amount of an antiemetic agent in particular Aprepitant and an effective amount of surface stabilizer in order to improve bioavailability. It also relates to a process for the preparation thereof.
    Type: Application
    Filed: November 15, 2017
    Publication date: September 12, 2019
    Applicant: PHARMATHEN S.A.
    Inventor: EVANGELOS KARAVAS
  • Publication number: 20190269612
    Abstract: The present invention relates to a preservative-free, aqueous solution in the form of eye drops packed in a container that ensures stability of the product, ideal eye drop volume and reduced drop volume variability and provides efficient dispensing.
    Type: Application
    Filed: May 7, 2019
    Publication date: September 5, 2019
    Applicant: PHARMATHEN S.A.
    Inventors: EVANGELOS KARAVAS, EFTHIMIOS KOUTRIS, VASILIKI SAMARA, IOANNA KOUTRI, ANASTASIA KALASKANI, ANDREAS KAKOURIS, GEORGE GOTZAMANIS
  • Patent number: 10350161
    Abstract: The present invention relates to a preservative-free, aqueous solution in the form of eye drops packed in a container that ensures stability of the product, ideal eye drop volume and reduced drop volume variability and provides efficient dispensing.
    Type: Grant
    Filed: October 14, 2014
    Date of Patent: July 16, 2019
    Assignee: PHARMATHEN S.A.
    Inventors: Evangelos Karavas, Efthimios Koutris, Vasiliki Samara, Ioanna Koutri, Anastasia Kalaskani, Andreas Kakouris, George Gotzamanis
  • Publication number: 20190209465
    Abstract: The present invention relates to the field of drug delivery and, particularly, to alternative processes for preparing ophthalmic compositions of Brinzolamide or pharmaceutical acceptable salts thereof.
    Type: Application
    Filed: July 1, 2016
    Publication date: July 11, 2019
    Applicant: PHARMATHEN S.A.
    Inventors: EVANGELOS KARAVAS, EFTHYMIOS KOUTRIS, VASILIKI SAMARA, IOANNA KOUTRI, ANASTASIA KALASKANI, AMALIA DIAKIDOU, ANDREAS KAKOURIS, RUMIT SHAH
  • Patent number: 10328076
    Abstract: The present invention relates to a stable pharmaceutical formulation of solid dosage forms for oral administration comprising a therapeutically effective amount of a triazole antifungal agent or pharmaceutical acceptable salt thereof, in particular Voriconazole and an effective amount of a solubility enhancing agent. It also relates to a process for the preparation thereof.
    Type: Grant
    Filed: June 9, 2015
    Date of Patent: June 25, 2019
    Assignee: PHARMATHEN S.A.
    Inventor: Evangelos Karavas
  • Publication number: 20190151293
    Abstract: The present invention relates to a stable pharmaceutical formulation of solid dosage forms for oral administration comprising a therapeutically effective amount of a non-purine selective inhibitor of xanthine oxidase, in particular Febuxostat and an effective amount of an alkalizing agent. It also relates to a process for the preparation thereof.
    Type: Application
    Filed: June 26, 2017
    Publication date: May 23, 2019
    Applicant: PHARMATHEN S.A.
    Inventors: EVANGELOS KARAVAS, EFTHYMIOS KOUTRIS, VASILIKI SAMARA, IOANNA KOUTRI, ANASTASIA KALASKANI, CHRISTINA KIZIRIDI, MORFIS ABATZIS, KATERINA TSILIOUKA
  • Publication number: 20190117562
    Abstract: The present invention relates to a preservative-free ophthalmic composition for the reduction of elevated intraocular pressure containing Latanoprost or a combination of Latanoprost and Timolol and to a process for preparing such compositions.
    Type: Application
    Filed: April 11, 2017
    Publication date: April 25, 2019
    Applicant: PHARMATHEN S.A.
    Inventors: Evangelos KARAVAS, Efthymios KOUTRIS, Vasiliki SAMARA, Ioanna KOUTRI, Anastasia KALASKANI, Andreas KAKOURIS, Manolis FOUSTERIS
  • Publication number: 20190105277
    Abstract: The present invention relates to controlled release pharmaceutical formulations comprising an atypical antipsychotic agent such as Paliperidone in the form of capsule filled with mini-tablets that provide zero order drug release. It also relates to a process for the preparation thereof.
    Type: Application
    Filed: April 5, 2016
    Publication date: April 11, 2019
    Applicant: PHARMATHEN S.A.
    Inventors: Evangelos KARAVAS, Efthimios KOUTRIS, Vasiliki SAMARA, Ioanna KOUTRI, Lida KALANTZI, Anastasia KALASKANI, Christina KIZIRIDI, Morfis ABATZIS
  • Publication number: 20190076442
    Abstract: The present invention relates to a preservative free ophthalmic pharmaceutical formulation for topical administration containing a therapeutically effective quantity of Bimatoprost or ophthalmological acceptable salts thereof and a therapeutically effective quantity of Timolol or ophthalmological acceptable salts thereof to be used for the treatment of ocular hypertension and glaucoma.
    Type: Application
    Filed: March 28, 2017
    Publication date: March 14, 2019
    Applicant: PHARMATHEN S.A.
    Inventor: EVANGELOS KARAVAS
  • Publication number: 20180214381
    Abstract: The present invention relates to controlled release pharmaceutical formulations comprising an atypical antipsychotic agent such as Paliperidone or pharmaceutical acceptable salt thereof in the form of a multi-layer tablet that provides zero order drug release. It also relates to a process for the preparation thereof.
    Type: Application
    Filed: July 7, 2016
    Publication date: August 2, 2018
    Applicant: PHARMATHEN S.A.
    Inventors: EVANGELOS KARAVAS, EFTHYMIOS KOUTRIS, VASILIKI SAMARA, IOANNA KOUTRI, ANASTASIA KALASKANI, LIDA KALANTZI, MORFIS ABATZIS, CHRISTINA KIZIRIDI
  • Patent number: 9943483
    Abstract: A novel process for the preparation of a long acting injectable composition based on biodegradable poly(D,L-lactide-co-glycolide) microspheres comprising peptide active pharmaceutical ingredients.
    Type: Grant
    Filed: March 31, 2014
    Date of Patent: April 17, 2018
    Assignee: PHARMATHEN S.A.
    Inventors: Evangelos Karavas, Efthymios Koutris, Katerina Minioti, Sotiria Chaitidou, Georgia Papanikolaou, Theofanis Mantourlias
  • Patent number: 9943484
    Abstract: The present invention relates to preparation of biodegradable microparticles formed from polylactide-polyglycolide copolymers (PLGA) polymer and how to achieve sigmoidal release of active pharmaceutical compound from the microparticles. In particular, the present invention relates to emulsification of an inner/oil phase to an outer/water phase followed by quenching and a single drying step for the preparation of microparticles having a preferred release profile of preferably basic/nucleophilic compounds such as risperidone. Alternatively the present invention is also suitable for hydrophobic compounds that have poor water-solubility and a high drug loading of >20% w/w is required. The release profile can be controlled by adjusting the degree of saturation of the outer/water phase with the organic solvent used in the inner/oil phase, the polymer concentration of the inner/oil phase and the temperature at the quenching step.
    Type: Grant
    Filed: June 18, 2014
    Date of Patent: April 17, 2018
    Assignee: PHARMATHEN S.A.
    Inventors: Evangelos Karavas, Efthymios Koutris, Sotiria Haitidou, Theofanis Mantourlias, Georgia Papanikolaou
  • Patent number: 9849147
    Abstract: The present invention relates to a fast dissolving tablet comprising a therapeutically effective amount of a phosphate binding polymer, such as sevelamer or pharmaceutically acceptable salt or derivative thereof, that exhibit limited swelling in the oral cavity, has pleasant taste and mouth feel, high phosphate binding capacity with fast binding kinetics and require limited amount of water intake. A process for the preparation thereof is disclosed.
    Type: Grant
    Filed: June 15, 2012
    Date of Patent: December 26, 2017
    Assignee: PHARMATHEN S.A.
    Inventors: Evangelos Karavas, Efthimios Koutris, Vasiliki Samara, Analia Diakidou, Georgia Papanikolaou, Panagiotis Mparmpalexis
  • Publication number: 20170281547
    Abstract: A novel process for the preparation of a long acting injectable composition based on biodegradable poly(D,L-lactide-co-glycolide) microspheres comprising peptide active pharmaceutical ingredients.
    Type: Application
    Filed: March 31, 2016
    Publication date: October 5, 2017
    Applicant: PHARMATHEN S.A.
    Inventors: EVANGELOS KARAVAS, EFTHYMIOS KOUTRIS, KATERINA MINIOTI, SOTIRIA CHAITIDOU, GEORGIA PAPANIKOLAOU, THEOFANIS MANTOURLIAS
  • Publication number: 20170202804
    Abstract: The present invention relates to water dispersible mini-tablets of Enalapril or a pharmaceutically acceptable salt thereof for use in the treatment of hypertension in a pediatric formulation. The pediatric formulation is defined as 0 to 18 years of age. The present invention also provides a method of manufacturing of such dosage form.
    Type: Application
    Filed: June 19, 2015
    Publication date: July 20, 2017
    Applicant: PHARMATHEN S.A.
    Inventors: EVANGELOS KARAVAS, EFTHYMIOS KOUTRIS, VASILIKI SAMARA, IOANNA KOUTRI, ANASTASIA KALASKANI, LIDA KALANTZI, ANDREAS KAKOURIS, AMALIA DIAKIDOU, GEORGE GOTZAMANIS, ZAHARIAS GEORGOUSIS, LOUIZA KONSTANTI
  • Publication number: 20170202844
    Abstract: The present invention relates to a pediatric chewable tablet comprising a therapeutically effective amount of an anti-viral agent or pharmaceutical acceptable salt or derivative thereof, in particular Valaciclovir in complex with an ion exchange resin in a specific ratio in order to obtain a palatable and child-friendly product. It also relates to a process for the preparation thereof.
    Type: Application
    Filed: June 19, 2015
    Publication date: July 20, 2017
    Applicant: PHARMATHEN S.A.
    Inventors: EVANGELOS KARAVAS, EFTHYMIOS KOUTRIS, VASILIKI SAMARA, IOANNA KOUTRI, ANASTASIA KALASKANI, LIDA KALANTZI, ANDREAS KAKOURIS, AMALIA DIAKIDOU, GEORGE GOTZAMANIS, ZAHARIAS GEORGOUSIS, MANOLIS FOUSTERIS
  • Publication number: 20170202843
    Abstract: The present invention relates to a pediatric powder for reconstitution as suspension for oral administration comprising a therapeutically effective amount of an antiviral agent or pharmaceutical acceptable salt or derivative thereof, in particular Valaciclovir in complex with an ion exchange resin in a specific ratio in order to obtain a palatable and child-friendly product. It also relates to a process for the preparation thereof.
    Type: Application
    Filed: June 19, 2015
    Publication date: July 20, 2017
    Applicant: PHARMATHEN S.A.
    Inventors: EVANGELOS KARAVAS, EFTHYMIOS KOUTRIS, VASILIKI SAMARA, IOANNA KOUTRI, ANASTASIA KALASKANI, LIDA KALANTZI, ANDREAS KAKOURIS, AMALIA DIAKIDOU, GEORGE GOTZAMANIS, ZAHARIAS GEORGOUSIS, MANOLIS FOUSTERIS
  • Publication number: 20170165315
    Abstract: The present invention relates to an oral applicable therapeutic dosage form, in particular an orodispersible film comprising Enalapril or pharmaceutically acceptable salts thereof for use in the treatment of hypertension in a pediatric population. The pediatric population is defined from 1 to 18 years of age. The present invention also provides a method of manufacturing of such a dosage form.
    Type: Application
    Filed: June 19, 2015
    Publication date: June 15, 2017
    Applicant: PHARMATHEN S.A.
    Inventors: EVANGELOS KARAVAS, EFTHYMIOS KOUTRIS, VASILIKI SAMARA, IOANNA KOUTRI, ANASTASIA KALASKANI, LIDA KALANTZI, ANDREAS KAKOURIS, AMALIA DIAKIDOU, GEORGE GOTZAMANIS, ZAHARIAS GEORGOUSIS, LOUIZA KONSTANTI
  • Patent number: 9675551
    Abstract: The present invention relates to a stable pharmaceutical composition for sublingual administration comprising a therapeutically effective quantity of an antihistamine agent, in particular Dimenhydnnate and a process for the preparation thereof.
    Type: Grant
    Filed: October 25, 2011
    Date of Patent: June 13, 2017
    Assignee: EXPERMED S.A.
    Inventors: Evangelos Karavas, Efthimios Koutris, Vicky Samara, Amalia Diakidou, Aggelos Karatzas
  • Publication number: 20170095477
    Abstract: The present invention relates to a stable pharmaceutical formulation of solid dosage forms for oral administration comprising a therapeutically effective amount of a triazole antifungal agent or pharmaceutical acceptable salt thereof, in particular Voriconazole and an effective amount of a solubility enhancing agent. It also relates to a process for the preparation thereof.
    Type: Application
    Filed: June 9, 2015
    Publication date: April 6, 2017
    Applicant: PHARMATHEN S.A.
    Inventor: EVANGELOS KARAVAS