Patents by Inventor Evans O. Onyango

Evans O. Onyango has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)dien-28-oyl) imidazole
    Patent number: 10501420
    Abstract: Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl) imidazole and pharmaceutical compositions containing the same are provided.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: December 10, 2019
    Assignee: TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Gordon W. Gribble, Michael B. Sporn, Karen T. Liby, Evans O. Onyango, Martine Cao
  • Composition and method for prevention, mitigation or treatment of an enteropathogenic bacterial infection
    Patent number: 10377716
    Abstract: Bicyclic compounds for decreasing the expression of bacterial virulence factors thereby preventing, mitigating, or treating bacterial infection are provided.
    Type: Grant
    Filed: October 16, 2017
    Date of Patent: August 13, 2019
    Assignee: TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: F. Jon Kull, Ronald K. Taylor, Gordon W. Gribble, Evans O. Onyango, Anne R. Kelley
  • PYRIDYL ANALOGS OF 1-(2-CYANO-3,12-DIOXOOLEANA-1,9(11)DIEN-28-OYL) IMIDAZOLE
    Publication number: 20190135763
    Abstract: Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl) imidazole and pharmaceutical compositions containing the same are provided.
    Type: Application
    Filed: December 21, 2018
    Publication date: May 9, 2019
    Inventors: Gordon W. Gribble, Michael B. Sporn, Karen T. Liby, Evans O. Onyango, Martine Cao
  • Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)dien-28-oyl) imidazole
    Patent number: 9896475
    Abstract: Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl) imidazole and pharmaceutical compositions containing the same are provided. The present invention is a tnterpenoid compound of Formula I, or a hydrate, isomer, prodrug or pharmaceutically acceptable salt thereof: wherein one or more of R, R or R is independently a substituted or unsubstituted aryl group, heteroaryl group, cycloalkyl group or heterocyclyl group, and the remaining R groups are hydrogen. The pyridyl analogs of CD-DO-1m 1 have been developed, which are more stable in human plasma and achieve a higher concentration in target tissues such as liver, pancreas, kidney and lungs.
    Type: Grant
    Filed: August 26, 2015
    Date of Patent: February 20, 2018
    Assignee: TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Gordon W. Gribble, Michael B. Sporn, Karen T. Liby, Evans O. Onyango, Martine Cao
  • COMPOSITION AND METHOD FOR PREVENTION, MITIGATION OR TREATMENT OF AN ENTEROPATHOGENIC BACTERIAL INFECTION
    Publication number: 20180029990
    Abstract: Bicyclic compounds for decreasing the expression of bacterial virulence factors thereby preventing, mitigating, or treating bacterial infection are provided.
    Type: Application
    Filed: October 16, 2017
    Publication date: February 1, 2018
    Inventors: F. Jon Kull, Ronald K. Taylor, Gordon W. Gribble, Evans O. Onyango, Anne R. Kelley
  • Composition and method for prevention, mitigation or treatment of an enteropathogenic bacterial infection
    Patent number: 9790186
    Abstract: Bicyclic compounds for decreasing the expression of bacterial virulence factors thereby preventing, mitigating, or treating bacterial infection are provided.
    Type: Grant
    Filed: August 27, 2015
    Date of Patent: October 17, 2017
    Assignee: TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: F. Jon Kull, Ronald K. Taylor, Gordon W. Gribble, Evans O. Onyango, Anne R. Kelley
  • PYRIDYL ANALOGS OF 1-(2-CYANO-3,12-DIOXOOLEANA-1,9(11)DIEN-28-OYL) IMIDAZOLE
    Publication number: 20170267713
    Abstract: Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl) imidazole and pharmaceutical compositions containing the same are provided. The present invention is a tnterpenoid compound of Formula I, or a hydrate, isomer, prodrug or pharmaceutically acceptable salt thereof: wherein one or more of R, R or R is independently a substituted or unsubstituted aryl group, heteroaryl group, cycloalkyl group or heterocyclyl group, and the remaining R groups are hydrogen. The pyridyl analogs of CD-DO-Im 1 have been developed, which are more stable in human plasma and achieve a higher concentration in target tissues such as liver, pancreas, kidney and lungs.
    Type: Application
    Filed: August 26, 2015
    Publication date: September 21, 2017
    Inventors: Gordon W. Gribble, Michael B. Sporn, Karen T. Liby, Evans O. Onyango, Martine Cao
  • CDDO-Me amino acid conjugates and methods of use
    Patent number: 9290455
    Abstract: 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid amino acid derivatives having antiinflammatory properties are provided. Pharmaceutical compositions and methods for preventing or treating inflammation or a disease or condition mediated by inflammation are described.
    Type: Grant
    Filed: February 11, 2014
    Date of Patent: March 22, 2016
    Assignee: Trustees of Dartmouth College
    Inventors: Michael B. Sporn, Karen T. Liby, Martine Cao, Evans O. Onyango, Liangfeng Fu, Gordon W. Gribble
  • COMPOSITION AND METHOD FOR PREVENTION, MITIGATION OR TREATMENT OF AN ENTEROPATHOGENIC BACTERIAL INFECTION
    Publication number: 20150361045
    Abstract: Bicyclic compounds for decreasing the expression of bacterial virulence factors thereby preventing, mitigating, or treating bacterial infection are provided.
    Type: Application
    Filed: August 27, 2015
    Publication date: December 17, 2015
    Applicant: Trustees of Dartmouth College
    Inventors: F. Jon Kull, Ronald K. Taylor, Gordon W. Gribble, Evans O. Onyango, Anne R. Kelley
  • CDDO-ME AMINO ACID CONJUGATES AND METHODS OF USE
    Publication number: 20150225352
    Abstract: 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid amino acid derivatives having antiinflammatory properties are provided. Pharmaceutical compositions and methods for preventing or treating inflammation or a disease or condition mediated by inflammation are described.
    Type: Application
    Filed: February 11, 2014
    Publication date: August 13, 2015
    Applicant: Trustees of Dartmouth College
    Inventors: Michael B. Sporn, Karen T. Liby, Martine Cao, Evans O. Onyango, Liangfeng Fu, Gordon W. Gribble