Patents by Inventor EVELINE DEN BIEZEN-TIMMERMANS

EVELINE DEN BIEZEN-TIMMERMANS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of prostate cancer prognosis
    Patent number: 11827938
    Abstract: The present invention relates to methods for diagnosing, monitoring or prognosticating prostate cancer or the progression state of prostate cancer wherein said method determines the state of the prostate cancer, based on the expression level of phosphodiesterase 4D (PDE4D) variants. The invention further relates to a method of identifying an individual for eligibility for prostate cancer therapy. The invention also relates to products for the analysis of phosphodiesterase 4D (PDE4D) variants as well as pharmaceutical compositions modulating the activity and/or expression of PDE4D variants.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: November 28, 2023
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Ralf Hoffmann, Eveline Den Biezen-Timmermans, Dianne Arnoldina Margaretha Wilhelmina Van Strijp, Anne Godefrida Catharina Van Brussel, Marcia Alves De Inda, Janneke Wrobel, Joannes Baptist Adrianus Dionisius Van Zon
  • Risk scores based on human phosphodiesterase 4D variant 7 expression
    Patent number: 11198909
    Abstract: Methods are described for stratifying patient risk for patients with prostate cancer and for providing a treatment recommendation to a patient based on a phosphodiesterase 4D variant 7 (PDE4D7) risk score. A diagnostic kit and a computer program product for the analysis and determination of the PDE4D7 risk score are also described.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: December 14, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Ralf Hoffmann, Eveline Den Biezen-Timmermans, Dianne Arnoldina Margaretha Wilhelmina Van Strijp, Anne Godefrida Catharina Van Brussel, Marcia Alves De Inda, Johannes Baptist Adrianus Dionisius Van Zon, Janneke Wrobel
  • METHODS OF PROSTATE CANCER PROGNOSIS
    Publication number: 20180148795
    Abstract: The present invention relates to methods for diagnosing, monitoring or prognosticating prostate cancer or the progression state of prostate cancer wherein said method determines the state of the prostate cancer, based on the expression level of phosphodiesterase 4D (PDE4D) variants. The invention further relates to a method of identifying an individual for eligibility for prostate cancer therapy. The invention also relates to products for the analysis of phosphodiesterase 4D (PDE4D) variants as well as pharmaceutical compositions modulating the activity and/or expression of PDE4D variants.
    Type: Application
    Filed: May 26, 2016
    Publication date: May 31, 2018
    Inventors: RALF HOFFMANN, EVELINE DEN BIEZEN-TIMMERMANS, DIANNE ARNOLDINA MARGARETHA WILHELMINA VAN STRIJP, ANNE GODEFRIDA CATHARINA VAN BRUSSEL, MARCIA ALVES DE INDA, JANNEKE WROBEL, JOANNES BAPTIST ADRIANUS DIONISIUS VAN ZON
  • METHODS OF PROSTATE CANCER PROGNOSIS
    Publication number: 20180148794
    Abstract: The present invention pertains to methods for determining gene expression signatures for diagnosing patients with prostate cancer, e.g., to establish a prognosis for such patients, for determining the predisposition of said patient to develop aggressive or indolent disease, for example after primary treatment, and/or for identification and stratification of patients for available therapies. The invention also relates to products used in such methods, e.g. kits, software, and the like. The present invention further relates to therapies for use in the treatment of patients that have been diagnosed, identified, or stratified in any of the methods dis closed herein.
    Type: Application
    Filed: May 26, 2016
    Publication date: May 31, 2018
    Inventors: RALF HOFFMANN, EVELINE DEN BIEZEN-TIMMERMANS, DIANNE ARNOLDINA MARGARETHA WILHELMINA VAN STRIJP, ANNE GODEFRIDA CATHARINA VAN BRUSSEL, MARCIA ALVES DE INDA, JANNEKE WROBEL
  • RISK SCORES BASED ON HUMAN PHOSPHODIESTERASE 4D VARIANT 7 EXPRESSION
    Publication number: 20170073778
    Abstract: Methods are described for stratifying patient risk for patients with prostate cancer and for providing a treatment recommendation to a patient based on a phosphodiesterase 4D variant 7 (PDE4D7) risk score. A diagnostic kit and a computer program product for the analysis and determination of the PDE4D7 risk score are also described.
    Type: Application
    Filed: December 1, 2016
    Publication date: March 16, 2017
    Inventors: RALF HOFFMANN, EVELINE DEN BIEZEN-TIMMERMANS, DIANNE Arnoldina Margaretha Wilhelmina VAN STRIJP, ANNE Godefrida Catharina VAN BRUSSEL, MARCIA ALVES DE INDA, JOHANNES Baptist Adrianus Dionisius VAN ZON, JANNEKE WROBEL