Abstract: Provided herein are new compositions comprising novel microparticles that are configured to provide a long acting release of one or more treprostinil compounds when administered to mammalian subjects. The microparticles of the invention are biocompatible and typically injectable through a needle or other injection system. The invention also provides methods of using such compositions, such as in the treatment of pulmonary arterial hypertension.

Abstract: Described herein are novel compositions comprising resorbable polyester polymers, such as poly-L-lactic acid particles, including novel compositions that function as neocollagenic dermal implants and that have unique physical properties as compared to compositions of similar composition previously known and/or used in the art. Also provided herein are novel systems comprising these compositions and related compositions and methods of using such compositions and systems, such as in aesthetic treatment.