Abstract: Provided herein are free base crystalline forms, crystalline salts, and an amorphous salts of omecamtiv mecarbil.

Abstract: A continuous wire drive system for a needleless electrospinning apparatus, the electrospinning apparatus including an electrospinning enclosure and within which a nanoscale or submicron scale polymer fiber web is formed onto a substrate from a liquid polymer layer coated onto a plurality of continuous electrode wires passing through the electrospinning enclosure. The continuous wire drive system includes a master wire drive drum and a slave wire drive drum, each of the master wire drive drum and slave wire drive drum including a plurality of wire guides, each of the wire guides including a channel or groove for receiving one of the plurality of continuous electrode wires. The continuous wire drive system is external to the electrospinning apparatus, and the continuous wire drive system drives the plurality of continuous electrode wires through the electrospinning enclosure.

Abstract: An apparatus for continuous needleless electrospinning of a nanoscale or submicron scale polymer fiber web onto a substrate includes an electrospinning enclosure that includes at least one liquid polymer coating device and an electro spinning zone and a wire drive system located external to the electro spinning enclosure. The wire drive system drives a plurality of continuous electrode wires through the electrospinning enclosure. A liquid polymer recycle and feed system is located external to the electrospinning enclosure and includes a recycle and feed tank that supplies liquid polymer to and receives overflow liquid polymer from the at least one liquid polymer coating device. A vapor collection and solvent recovery system includes at least one exhaust stream, collects and processes vapors generated in the electrospinning enclosure, and maintains a pressure in the electrospinning enclosure that is lower than atmospheric pressure.

Abstract: A continuous wire drive system for a needleless electrospinning apparatus, the electrospinning apparatus including an electrospinning enclosure and within which a nanoscale or submicron scale polymer fiber web is formed onto a substrate from a liquid polymer layer coated onto a plurality of continuous electrode wires passing through the electrospinning enclosure. The continuous wire drive system includes a master wire drive drum and a slave wire drive drum, each of the master wire drive drum and slave wire drive drum including a plurality of wire guides, each of the wire guides including a channel or groove for receiving one of the plurality of continuous electrode wires. The continuous wire drive system is external to the electrospinning apparatus, and the continuous wire drive system drives the plurality of continuous electrode wires through the electrospinning enclosure.

Abstract: An apparatus for continuous needleless electrospinning of a nanoscale or submicron scale polymer fiber web onto a substrate includes an electrospinning enclosure that includes at least one liquid polymer coating device and an electro spinning zone and a wire drive system located external to the electro spinning enclosure. The wire drive system drives a plurality of continuous electrode wires through the electrospinning enclosure. A liquid polymer recycle and feed system is located external to the electrospinning enclosure and includes a recycle and feed tank that supplies liquid polymer to and receives overflow liquid polymer from the at least one liquid polymer coating device. A vapor collection and solvent recovery system includes at least one exhaust stream, collects and processes vapors generated in the electrospinning enclosure, and maintains a pressure in the electrospinning enclosure that is lower than atmospheric pressure.

Abstract: A continuous wire drive system for a needleless electrospinning apparatus, the electrospinning apparatus including an electrospinning enclosure and within which a nanoscale or submicron scale polymer fiber web is formed onto a substrate from a liquid polymer layer coated onto a plurality of continuous electrode wires passing through the electrospinning enclosure. The continuous wire drive system includes a master wire drive drum and a slave wire drive drum, each of the master wire drive drum and slave wire drive drum including a plurality of wire guides, each of the wire guides including a channel or groove for receiving one of the plurality of continuous electrode wires. The continuous wire drive system is external to the electrospinning apparatus, and the continuous wire drive system drives the plurality of continuous electrode wires through the electrospinning enclosure.

Abstract: A continuous wire drive system for a needleless electrospinning apparatus, the electrospinning apparatus including an electrospinning enclosure and within which a nanoscale or submicron scale polymer fiber web is formed onto a substrate from a liquid polymer layer coated onto a plurality of continuous electrode wires passing through the electrospinning enclosure. The continuous wire drive system includes a master wire drive drum and a slave wire drive drum, each of the master wire drive drum and slave wire drive drum including a plurality of wire guides, each of the wire guides including a channel or groove for receiving one of the plurality of continuous electrode wires. The continuous wire drive system is external to the electrospinning apparatus, and the continuous wire drive system drives the plurality of continuous electrode wires through the electrospinning enclosure.

Abstract: An apparatus for continuous needless electrospinning of a liquid polymer source into a nanoscale or submicron scale polymer fiber web includes an electrospinning enclosure, a wire drive system located external to the electrospinning enclosure and a plurality of continuous electrode wires. The electrospinning enclosure includes and electrospinning zone and one or more liquid polymer coating devices where liquid polymer is coated onto the plurality of continuous electrode wires. The plurality of continuous electrode wires are parallel to each other, engaged with the wire drive system, and extend through the electrospinning enclosure and the one or more liquid polymer coating devices located therein. High voltage is applied to the plurality of continuous electrode wires in the electrospinning zone to form nanoscale or submicron scale polymer fibers from the liquid polymer coated on the electrode wires.

Abstract: An apparatus for continuous needless electrospinning of a liquid polymer source into a nanoscale or submicron scale polymer fiber web includes an electrospinning enclosure, a wire drive system located external to the electrospinning enclosure and a plurality of continuous electrode wires. The electrospinning enclosure includes and electrospinning zone and one or more liquid polymer coating devices where liquid polymer is coated onto the plurality of continuous electrode wires. The plurality of continuous electrode wires are parallel to each other, engaged with the wire drive system, and extend through the electrospinning enclosure and the one or more liquid polymer coating devices located therein. High voltage is applied to the plurality of continuous electrode wires in the electrospinning zone to form nanoscale or submicron scale polymer fibers from the liquid polymer coated on the electrode wires.