Patents by Inventor Everson Nogoceke

Everson Nogoceke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR MONITORING CATHEPSIN S INHIBITION
    Publication number: 20170192000
    Abstract: The present invention relates to a method for monitoring Cathepsin S inhibitor activity in tissue samples of animals comprising: a) providing a tissue sample of an animal to whom a Cathepsin S inhibitor has been administered or providing a tissue sample of an animal that was contacted in vitro with a Cathepsin S inhibitor, wherein the tissue samples comprise white blood cells, b) measuring li p10 peptide level in white blood cells of the tissue sample of step a) by flow cytometry and c) correlating li p10 peptide level in white blood cells to Cathepsin S inhibitor dose, wherein a Cathepsin S inhibitor leads to increased level of li p10 peptide in the white blood cells.
    Type: Application
    Filed: March 10, 2017
    Publication date: July 6, 2017
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Ana Patricia BENTO PEREIRA DA SILVA, Sebastian DZIADEK, Barbara ECABERT, Michael GERG, Everson NOGOCEKE, Moritz MARCINOWSKI, Bernhard REIS, Thomas SCHINDLER, Michel Achille Edouard THERON
  • PREDICTING RAPID DECLINE IN RENAL FUNCTION IN DIABETES
    Publication number: 20170115310
    Abstract: Methods of predicting rapid decline in renal function in diabetes employing panels of biomarkers. The methods are useful for predicting risk of decline of renal function in individual subject and also for selecting subjects for clinical trials.
    Type: Application
    Filed: March 18, 2015
    Publication date: April 27, 2017
    Inventors: Helen COLHOUN, Helen LOOKER, Paul MCKEIGUE, Marco COLUMBO, David DUNGER, Neil DALTON, Mary Julia BROSNAN, Everson NOGOCEKE, Felix AGAKOV, Sibylle HESS
  • ANTIBODY BINDING TO ABCA1 POLYPEPTIDE
    Publication number: 20120322083
    Abstract: The invention relates to an isolated antibody that binds to native ABCA1 polypeptide and its uses for the detection of ABCA1 polypeptides in tissue samples.
    Type: Application
    Filed: June 14, 2012
    Publication date: December 20, 2012
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Barbara Ecabert, Hugues Matile, Everson Nogoceke, Bernhard Reis, Haiyan Wang
  • CALIBRATION REAGENT AND USES THEREOF
    Publication number: 20120220489
    Abstract: The present invention provides a calibration reagent comprising a peptide conjugated to a protein carrier via a linker, wherein said peptide comprises an epitope of interest and the use thereof.
    Type: Application
    Filed: November 12, 2010
    Publication date: August 30, 2012
    Inventors: Maziar Assadi Gehr, Everson Nogoceke
  • Tryparedoxin, expression plasmid, process of preparation, method of use, test kit and pharmaceutical composition
    Publication number: 20050143559
    Abstract: The present invention provides novel enzymes, tryparedoxins, their isolation from Crithidia fasciculata, a method for the production thereof in genetically transformed bacteria, and their use as molecular targets for the discovery of trypanocidal drugs
    Type: Application
    Filed: October 12, 2004
    Publication date: June 30, 2005
    Inventors: Leopold Flohe, Everson Nogoceke, Henryk Kalisz, Marisa Montemartini
  • Tryparedoxin, expression plasmid, process of production, method of use, test kit, and pharmaceutical composition
    Patent number: 6432671
    Abstract: The present invention provides novel enzymes, tryparedoxins, their isolation from Crithidia fasciculata, a method for the production thereof in genetically transformed bacteria, and their use as molecular targets for the discovery of trypanocidal drugs.
    Type: Grant
    Filed: June 11, 1999
    Date of Patent: August 13, 2002
    Inventors: Leopold Flohé, Everson Nogoceke, Henryk Kalisz, Marisa Montemartini