Patents by Inventor Evgeni V. SOKURENKO

Evgeni V. SOKURENKO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for treatment and prevention of uropathogenic infection
    Patent number: 10722580
    Abstract: Methods and antibody compositions that displace mannose from the binding pocket of fimbrial adhesin FimH of enterobacteria, including uropathogenic E. coli, Klebsiella oxytoca, or Klebsiella pneumoniae, can be used to disrupt or prevent the attachment of a single layer of bacteria to a mannose-coated surface, or to disrupt or prevent the formation of a multilayer biofilm. The antibody compositions of the invention can thus be used in methods to inhibit, prevent, or reverse the colonization of a surface with enterobacteria that express the bacterial Type 1 fimbrial adhesin FimH, to inhibit or prevent infection of a cell by enterobacteria that express the bacterial Type 1 fimbrial adhesin FimH, such as, for example, uropathogenic E. coli, to treat a bacterial infection in subject in need thereof and to treat or prevent inflammatory bowel disease (IBD), among other uses.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: July 28, 2020
    Assignee: UNIVERSITY OF WASHINGTON
    Inventors: Evgeni V. Sokurenko, Dagmara Kisiela, Wendy Evelyn Thomas, Veronika L. Tchesnokova
  • COMPOSITIONS AND METHODS FOR TREATMENT AND PREVENTION OF UROPATHOGENIC E. COLI INFECTION
    Publication number: 20180193457
    Abstract: Methods and antibody compositions that displace mannose from the binding pocket of fimbrial adhesin FimH of enterobacteria, including uropathogenic E. coli, Klebsiella oxytoca, or Klebsiella pneumoniae, can be used to disrupt or prevent the attachment of a single layer of bacteria to a mannose-coated surface, or to disrupt or prevent the formation of a multilayer biofilm. The antibody compositions of the invention can thus be used in methods to inhibit, prevent, or reverse the colonization of a surface with enterobacteria that express the bacterial Type 1 fimbrial adhesin FimH, to inhibit or prevent infection of a cell by enterobacteria that express the bacterial Type 1 fimbrial adhesin FimH, such as, for example, uropathogenic E. coli, to treat a bacterial infection in subject in need thereof and to treat or prevent inflammatory bowel disease (IBD), among other uses.
    Type: Application
    Filed: May 13, 2016
    Publication date: July 12, 2018
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: Evgeni V. SOKURENKO, Dagmara KISIELA, Wendy Evelyn THOMAS, Veronika L. TCHESNOKOVA
  • Primers, assays and methods for detecting an subtype
    Patent number: 9834823
    Abstract: Disclosed are primers, probes, and single nucleotide polymorphisms (SNP) specific to a distinct subclones of the E. coli sequence type 131 (ST131). Also disclosed are methods and assay kits useful in detecting the presence of the distinct subtype of E. coli and methods of treating a subject suffering from an infection from a subclone of ST131.
    Type: Grant
    Filed: July 2, 2013
    Date of Patent: December 5, 2017
    Inventors: Lance B. Price, Evgeni V. Sokurenko, James R. Johnson
  • High-Resolution Clonal Typing of Escherichia coli
    Publication number: 20140193824
    Abstract: The present invention provides methods and compositions for high-resolution clonal typing of Escherichia coli.
    Type: Application
    Filed: January 2, 2014
    Publication date: July 10, 2014
    Inventors: Evgeni V. SOKURENKO, James R. JOHNSON, Scott WEISSMAN, Veronika TCHESNOKOVA