Patents by Inventor Evgenia Mikhailovna Kim
Evgenia Mikhailovna Kim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9097900Abstract: Some systems described herein include a frequency dependent phase plate for generating multiple phase-contrast images of a sample, each from a different frequency range of light, each phase-contrast image for frequency range of light formed from light diffracted by the sample interfered with undiffracted light that has a frequency-dependent baseline relative phase shift from the phase plate. In some embodiments, the multiple phase-contrast images may be used to generate a quantitative phase image of a sample. The phase-contrast images or the produced quantitative phase image may have sufficient contrast for label-free auto-segmentation of cell bodies and nuclei.Type: GrantFiled: June 14, 2012Date of Patent: August 4, 2015Assignee: General Electric CompanyInventors: Evgenia Mikhailovna Kim, Robert John Filkins, Chulmin Joo
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Patent number: 8977331Abstract: Systems and methods for imaging are presented. The method includes producing excitation light configured to induce fluorescence in an imaging agent that selectively binds to a target species in a region of interest (ROI) of a subject that also includes a background species. A first and a second spectral region are selected such that a determined difference between fluorescence corresponding to the target and the background species in the first spectral region differs from a corresponding difference in the second spectral region. First and second fluorescence images are generated from the fluorescence corresponding to the first and second spectral regions. Additionally, a fluorescence ratio for the background species in the first and second fluorescence image is determined. The first fluorescence image is then multiplied or divided with the determined ratio to generate an intermediate image that is subtracted from the second fluorescent image to reconstruct a background-subtracted image.Type: GrantFiled: December 13, 2012Date of Patent: March 10, 2015Assignee: General Electric CompanyInventors: Evgenia Mikhailovna Kim, Siavash Yazdanfar, Cristina Abucay Tan Hehir
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Patent number: 8934103Abstract: Systems and methods described herein employ multiple phase-contrast images with various relative phase shifts between light diffracted by a sample and light not diffracted by the sample to produce a quantitative phase image. The produced quantitative phase image may have sufficient contrast for label-free auto-segmentation of cell bodies and nuclei.Type: GrantFiled: October 29, 2012Date of Patent: January 13, 2015Assignee: General Electric CompanyInventors: Evgenia Mikhailovna Kim, Siavash Yazdanfar, Dmitry Vladimirovich Dylov
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Patent number: 8778568Abstract: An optical data storage medium is provided. The optical data storage medium includes a polymer matrix; a reactant capable of undergoing a change upon triplet excitation, thereby causing a refractive index change; and a non-linear sensitizer capable of absorbing actinic radiation to cause upper triplet energy transfer to said reactant. The refractive index change capacity of the medium is at least about 0.005. The non-linear sensitizer comprises a triarylmethane dye.Type: GrantFiled: December 14, 2010Date of Patent: July 15, 2014Assignee: General Electric CompanyInventors: Arunkumar Natarajan, Patrick Joseph McCloskey, Eugene Pauling Boden, Kwok Pong Chan, Matthew Jeremiah Misner, Evgenia Mikhailovna Kim
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Publication number: 20140171764Abstract: Systems and methods for imaging are presented. The method includes producing excitation light configured to induce fluorescence in an imaging agent that selectively binds to a target species in a region of interest (ROI) of a subject that also includes a background species. A first and a second spectral region are selected such that a determined difference between fluorescence corresponding to the target and the background species in the first spectral region differs from a corresponding difference in the second spectral region. First and second fluorescence images are generated from the fluorescence corresponding to the first and second spectral regions. Additionally, a fluorescence ratio for the background species in the first and second fluorescence image is determined. The first fluorescence image is then multiplied or divided with the determined ratio to generate an intermediate image that is subtracted from the second fluorescent image to reconstruct a background-subtracted image.Type: ApplicationFiled: December 13, 2012Publication date: June 19, 2014Applicant: GENERAL ELECTRIC COMPANYInventors: Evgenia Mikhailovna Kim, Siavash Yazdanfar, Cristina Abucay Tan Hehir
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Patent number: 8703388Abstract: Optical data storage media for bit-wise recording of a microhologram using an incident radiation at a wavelength of about 405 nm are provided. The optical storage medium includes (a) a non-photopolymer polymer matrix; (b) a non-linear sensitizer comprising a phenylethynyl platinum complex, wherein the non-linear sensitizer is capable of triplet-triplet energy transfer from an upper triplet state (Tn) of the non-linear sensitizer to a lower triplet state (T1) of a reactant, wherein ānā is an integer greater than 1; and (c) a reactant capable of undergoing a chemical change upon the triplet-triplet energy transfer from the non-linear sensitizer, thereby causing a refractive index change in the medium to record the microhologram.Type: GrantFiled: February 27, 2012Date of Patent: April 22, 2014Assignee: General Electric CompanyInventors: Arunkumar Natarajan, Riffard Pierre Jean-Gilles, Kwok Pong Chan, Robert James Perry, Victor Petrovich Ostroverkhov, Evgenia Mikhailovna Kim, Julia Lam Lee, Eugene Pauling Boden, Patrick Joseph McCloskey, Brian Lee Lawrence
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Patent number: 8693000Abstract: Systems and methods described herein employ multiple phase-contrast images with various relative phase shifts between light diffracted by a sample and light not diffracted by the sample to produce a quantitative phase image. The produced quantitative phase image may have sufficient contrast for label-free auto-segmentation of cell bodies and nuclei.Type: GrantFiled: December 22, 2011Date of Patent: April 8, 2014Assignee: General Electric CompanyInventors: Evgenia Mikhailovna Kim, Robert John Fikins, Chulmin Joo
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Publication number: 20130335548Abstract: Some systems described herein include a frequency dependent phase plate for generating multiple phase-contrast images of a sample, each from a different frequency range of light, each phase-contrast image for frequency range of light formed from light diffracted by the sample interfered with undiffracted light that has a frequency-dependent baseline relative phase shift from the phase plate. In some embodiments, the multiple phase-contrast images may be used to generate a quantitative phase image of a sample. The phase-contrast images or the produced quantitative phase image may have sufficient contrast for label-free auto-segmentation of cell bodies and nuclei.Type: ApplicationFiled: June 14, 2012Publication date: December 19, 2013Applicant: GENERAL ELECTRIC COMPANYInventors: Evgenia Mikhailovna Kim, Robert John Filkins, Chulmin Joo
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Patent number: 8580463Abstract: The present disclosure relates generally to optical data storage media, and more specifically, to holographic storage media. In one embodiment, an optical storage medium includes a polymer matrix having one or more polymer chains. The optical storage medium also includes a reverse saturable absorption (RSA) sensitizer disposed within the polymer matrix that is configured to become excited upon exposure to light having an intensity above an intensity threshold and configured to transfer energy to a reactant. The optical storage medium also includes a diphenyl cyclopropene (DPCP)-derivative reactant disposed within the polymer matrix and capable of undergoing a modification upon receiving an energy transfer from the excited sensitizer that changes a refractive index of the optical medium.Type: GrantFiled: November 17, 2011Date of Patent: November 12, 2013Assignee: General Electric CompanyInventors: Arunkumar Natarajan, Patrick Joseph McCloskey, Eugene Pauling Boden, Kwok Pong Chan, Evgenia Mikhailovna Kim
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Patent number: 8580464Abstract: The invention relates generally to optical data storage media, and more specifically, to holographic storage media. In one embodiment, an optical storage medium composition includes a polymer matrix. Disposed within the polymer matrix is a reactant capable of undergoing a modification that alters the refractive index of the composition upon receiving an energy transfer from an excited sensitizer. A non-linear sensitizer is also disposed within the polymer matrix, and the sensitizer includes a metal-substituted subphthalocyanine (M-sub-PC) reverse saturable absorber configured to become excited upon exposure to light beyond an intensity threshold at approximately 405 nm and configured to transfer energy to the reactant.Type: GrantFiled: November 17, 2011Date of Patent: November 12, 2013Assignee: General Electric CompanyInventors: Arunkumar Natarajan, Patrick Joseph McCloskey, Kwok Pong Chan, Evgenia Mikhailovna Kim, Robert Edgar Colborn, Eugene Pauling Boden
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Publication number: 20130286400Abstract: Systems and methods described herein employ multiple phase-contrast images with various relative phase shifts between light diffracted by a sample and light not diffracted by the sample to produce a quantitative phase image. The produced quantitative phase image may have sufficient contrast for label-free auto-segmentation of cell bodies and nuclei.Type: ApplicationFiled: October 29, 2012Publication date: October 31, 2013Inventors: Evgenia Mikhailovna Kim, Siavash Yazdanfar, Dmitry Vladimirovich Dylov
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Patent number: 8507153Abstract: There are provided compositions, optical data storage media and methods of using the optical data storage media. The compositions comprise a non-linear sensitizer comprising one or more subphthalocyanine reverse saturable absorbers capable of absorbing actinic radiation to cause upper triplet energy transfer to a reactant that undergoes a photochemical change upon triplet excitation.Type: GrantFiled: August 31, 2009Date of Patent: August 13, 2013Assignee: General Electric CompanyInventors: Arunkumar Natarajan, Kwok Pong Chan, Riffard Pierre Jean-Gilles, Robert James Perry, Victor Petrovich Ostroverkhov, Evgenia Mikhailovna Kim, Julia Lam Lee, Eugene Pauling Boden, Patrick Joseph McCloskey, Brian Lee Lawrence
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Patent number: 8475975Abstract: In accordance with one aspect of the present invention, a method for recording holographic data in an optical data storage medium is provided. The method includes (i) providing an optical data storage medium including: (a) a thermoplastic polymer matrix, (b) a latent acid generator, (c) a non-linear sensitizer, and (d) a reactant including a latent chromophore. The method further includes (ii) irradiating a volume element of the optical data storage medium with an interference pattern, said interference pattern including an incident radiation having a wavelength and an intensity sufficient to cause upper triplet energy transfer from the non-linear sensitizer to the latent acid generator, thereby generating an acid, wherein the latent acid generator is substantially non-responsive to said incident radiation.Type: GrantFiled: June 21, 2011Date of Patent: July 2, 2013Assignee: General Electric CompanyInventors: Arunkumar Natarajan, Eugene Pauling Boden, Dmitry Vladimirovich Dylov, James Edward Pickett, Evgenia Mikhailovna Kim, Patrick Joseph McCloskey, Kwok Pong Chan, Victor Petrovich Ostroverkhov, Matthew Jeremiah Misner, Vijay Krishna Paruchuru
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Publication number: 20130163002Abstract: Systems and methods described herein employ multiple phase-contrast images with various relative phase shifts between light diffracted by a sample and light not diffracted by the sample to produce a quantitative phase image. The produced quantitative phase image may have sufficient contrast for label-free auto-segmentation of cell bodies and nuclei.Type: ApplicationFiled: December 22, 2011Publication date: June 27, 2013Applicant: GENERAL ELECTRIC COMPANYInventors: Evgenia Mikhailovna Kim, Robert John Filkins, Chulmin Joo
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Publication number: 20130128713Abstract: The invention relates generally to optical data storage media, and more specifically, to holographic storage media. In one embodiment, an optical storage medium composition includes a polymer matrix. Disposed within the polymer matrix is a reactant capable of undergoing a modification that alters the refractive index of the composition upon receiving an energy transfer from an excited sensitizer. A non-linear sensitizer is also disposed within the polymer matrix, and the sensitizer includes a metal-substituted subphthalocyanine (M-sub-PC) reverse saturable absorber configured to become excited upon exposure to light beyond an intensity threshold at approximately 405 nm and configured to transfer energy to the reactant.Type: ApplicationFiled: November 17, 2011Publication date: May 23, 2013Applicant: General Electric CompanyInventors: Arunkumar Natarajan, Patrick Joseph McCloskey, Kwok Pong Chan, Evgenia Mikhailovna Kim, Robert Edgar Colborn, Eugene Pauling Boden
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Publication number: 20130128712Abstract: The present disclosure relates generally to optical data storage media, and more specifically, to holographic storage media. In one embodiment, an optical storage medium includes a polymer matrix having one or more polymer chains. The optical storage medium also includes a reverse saturable absorption (RSA) sensitizer disposed within the polymer matrix that is configured to become excited upon exposure to light having an intensity above an intensity threshold and configured to transfer energy to a reactant. The optical storage medium also includes a diphenyl cyclopropene (DPCP)-derivative reactant disposed within the polymer matrix and capable of undergoing a modification upon receiving an energy transfer from the excited sensitizer that changes a refractive index of the optical medium.Type: ApplicationFiled: November 17, 2011Publication date: May 23, 2013Applicant: General Electric CompanyInventors: Arunkumar Natarajan, Patrick Joseph McCloskey, Eugene Pauling Boden, Kwok Pong Chan, Evgenia Mikhailovna Kim
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Patent number: 8343608Abstract: The present disclosure relates to optical media and the formation and use of such media. In certain embodiments the optical media or a composition suitable for such media includes a polymeric matrix or substrate. A dye, such as an energy transfer dye is chemically appended to the polymeric matrix or substrate, such as by one or more covalent bonds.Type: GrantFiled: August 31, 2010Date of Patent: January 1, 2013Assignee: General Electric CompanyInventors: Arunkumar Natarajan, Evgenia Mikhailovna Kim, Vicki Herzl Watkins, Julia Lam Lee, Patrick Joseph McCloskey, Kwok Pong Chan, Matthew Jeremiah Misner, Victor Petrovich Ostroverkhov
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Publication number: 20120328973Abstract: In accordance with one aspect of the present invention, a method for recording holographic data in an optical data storage medium is provided. The method includes (i) providing an optical data storage medium including: (a) a thermoplastic polymer matrix, (b) a latent acid generator, (c) a non-linear sensitizer, and (d) a reactant including a latent chromophore. The method further includes (ii) irradiating a volume element of the optical data storage medium with an interference pattern, said interference pattern including an incident radiation having a wavelength and an intensity sufficient to cause upper triplet energy transfer from the non-linear sensitizer to the latent acid generator, thereby generating an acid, wherein the latent acid generator is substantially non-responsive to said incident radiation.Type: ApplicationFiled: June 21, 2011Publication date: December 27, 2012Applicant: GENERAL ELECTRIC COMPANYInventors: Arunkumar Natarajan, Eugene Pauling Boden, Dmitry Vladimirovich Dylov, James Edward Pickett, Evgenia Mikhailovna Kim, Patrick Joseph McCloskey, Kwok Pong Chan, Victor Petrovich Ostroverkhov, Matthew Jeremiah Misner, Vijay Krishna Paruchuru
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Publication number: 20120250120Abstract: A holographic system for recording and reading information is provided. The system includes at least one laser for providing a laser beam. The system also includes a subsystem configured for multi-wavelength operation of said holographic system and recording micro-holograms at different wavelengths in substantially non-overlapping volumes of a holographic medium.Type: ApplicationFiled: March 31, 2011Publication date: October 4, 2012Applicant: GENERAL ELECTRIC COMPANYInventors: Victor Petrovich Ostroverkhov, John Anderson Fergus Ross, Arunkumar Natarajan, Patrick Joseph McCloskey, Kwok Pong Chan, Evgenia Mikhailovna Kim
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Publication number: 20120163145Abstract: Optical data storage media for bit-wise recording of a microhologram using an incident radiation at a wavelength of about 405 nm are provided. The optical storage medium includes (a) a non-photopolymer polymer matrix; (b) a non-linear sensitizer comprising a phenylethynyl platinum complex, wherein the non-linear sensitizer is capable of triplet-triplet energy transfer from an upper triplet state (Tn) of the non-linear sensitizer to a lower triplet state (T1) of a reactant, wherein ānā is an integer greater than 1; and (c) a reactant capable of undergoing a chemical change upon the triplet-triplet energy transfer from the non-linear sensitizer, thereby causing a refractive index change in the medium to record the microhologram.Type: ApplicationFiled: February 27, 2012Publication date: June 28, 2012Applicant: GENERAL ELECTRIC COMPANYInventors: Arunkumar Natarajan, Riffard Pierre Jean-Gilles, Kwok Pong Chan, Robert James Perry, Victor Petrovich Ostroverkhov, Evgenia Mikhailovna Kim, Julia Lam Lee, Eugene Pauling Boden, Patrick Joseph McCloskey, Brian Lee Lawrence