Abstract: The present invention relates to medicine, more particularly to pharmaceutical or cosmetic compositions, used for application on the skin, including the region of eyes, as well as on the lips and the mucosa of nasal, oral and laryngeal cavities of the man or the animal, with the purpose of preventing or reducing itch and local reaction from stings of insects, in particular mosquitoes, wasps, horse-flies etc. Local reaction from stings of insects is understood as pain, burning sensation, tissue edema, and hyperemia (redness around the sting site). The pharmaceutical or cosmetic composition, preventing or reducing the itch and the local reaction from the stings of insects, contains soluble salt or mixture of soluble salts of one or several rare earth elements, triethylene glycol, glycerine, polyethylene oxide, ethanol, sodium (potassium) hydroxide and water.