Patents by Inventor Evgeny Iosifovich Grigoriev

Evgeny Iosifovich Grigoriev has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8524674
    Abstract: Disclosed is a method of improving the conditioned reflex habit, the muscle tonus, or the motion coordination of a patient after suffering trauma to the brain cortex that involves administering to the patient an effective amount of a composition containing peptide glutamyl-aspartyl-arginine of the formula H-Glu-Asp-Arg-OH as its active base.
    Type: Grant
    Filed: August 15, 2012
    Date of Patent: September 3, 2013
    Assignee: Obschestvo S Ogranichennoi Otvetstvennostyu “Sia Peptides”
    Inventors: Vladimir Khatskelevich Khavinson, Evgeny Iosifovich Grigoriev, Vladimir Victorovich Malinin, Galina Anatolievna Ryzhak
  • Publication number: 20120309688
    Abstract: Disclosed is a method of treating diseases. traumas. as well as consequences of traumas of the central nervous system. and a method for stimulating neurons regeneration. which involves the use of a peptide glutamyl-aspartyl-arginine. Also disclosed are a pharmaceutical composition containing the above peptide and a pharmaceutically acceptable carrier and a method of stimulating the regeneration of neurons by administering to a patient a pharmaceutical composition containing the above peptide in the dose of 0.01-100 ?g/kg of body weight at least once a day during a period necessary for attaining the therapeutic effect. such administration being performed parenterally.
    Type: Application
    Filed: August 15, 2012
    Publication date: December 6, 2012
    Applicant: OBSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTYU "SIA PEPTIDES"
    Inventors: Vladimir Khatskelevich KHAVINSON, Evgeny Iosifovich GRIGORIEV, Vladimir Victorovich MALININ, Galina Anatolievna RYZHAK
  • Patent number: 8071556
    Abstract: Disclosed is a peptide glutamyl-aspartyl-glycine with general formula H-Glu-Asp-Gly-OH sequence 1 [SEQ ID NO:1], having a stress protective effect. Also disclosed is a pharmaceutical composition comprising the peptide and a pharmaceutically acceptable carrier. Also disclosed is a method of preventing or treating functional or stress induced disorders in a patient wherein the method involves administering an effective amount of the peptide to the patient.
    Type: Grant
    Filed: March 5, 2007
    Date of Patent: December 6, 2011
    Assignee: Obschestvo S Ogranichennoi Otvetstevennostyu “Sia Peptides”
    Inventors: Vladimir Khatskelevich Khavinson, Evgeny Iosifovich Grigoriev, Vladimir Victorovich Malinin, Galina Anatolievna Ryzhak
  • Patent number: 8057810
    Abstract: Disclosed is a pharmaceutical composition for the prevention and correction of age-related disorders of cellular and humoral immunity and having an immunogeroprotective effect. The pharmaceutical composition includes a peptide glutamyl-aspartyl-proline with general formula H-Glu-Asp-Pro-OH sequence 1 [SEQ ID NO:1]. The pharmaceutical composition can be in the form suitable for parenteral administration. Also disclosed is a method of prevention and/or correction of age-related disorders of cellular and humoral immunity by stimulating the processes of lymphocytes proliferation and differentiation, such method consisting in the administration to a patient of a pharmaceutical composition containing an effective amount of peptide glutamyl-aspartyl-proline with general formula: H-Glu-Asp-Pro-OH sequence 1 [SEQ ID NO:1] in the dose of 0.01-100 ?g/kg of body weight as an active base at least once a day during a period necessary for attaining a therapeutic effect.
    Type: Grant
    Filed: March 2, 2007
    Date of Patent: November 15, 2011
    Assignee: Obschestvo S Ogranichennoi Otvetstvennostyu “Sia Peptides”
    Inventors: Vladimir Khatskelevich Khavinson, Evgeny Iosifovich Grigoriev, Vladimir Victorivich Malinin, Galina Anatolievna Ryzhak
  • Patent number: 7851449
    Abstract: The invention is related to the medicinal means of correction of metabolic vascular syndrome and diseases, associated with disordered vascular wall permeability and capillaries fragility, and can be used as a means of enhancing capillaries resistance. There is proposed a peptide lysyl-glutamyl-asparagine acid of the general formula H-Lys-Glu-Asp-OH sequence 1 [SEQ ID NO:1], revealing biological activity and capable of enhancing capillaries resistance. There is also proposed a pharmaceutical composition enhancing capillaries resistance, containing effective amount of peptide lysyl-glutamyl-asparagine acid of the general formula H-Lys-Glu-Asp-OH sequence 1 [SEQ ID NO: 1] as its active base and pharmaceutically acceptable carrier. This pharmaceutical composition is in form for parenteral administration.
    Type: Grant
    Filed: December 4, 2006
    Date of Patent: December 14, 2010
    Assignee: Obschestvo S Ogranichennoi Otvetstvennostyu “SIA Peptides”
    Inventors: Vladimir Khatskelevich Khavinson, Evgeny Iosifovich Grigoriev, Vladimir Victorovich Malinin, Galina Anatolievna Ryzhak
  • Patent number: 7662789
    Abstract: The invention refers to the pharmaceutical means for the treatment of cardiovascular diseases and can be used as a substance restoring myocardium function in the course of treatment for different forms of this pathology. There is proposed a new tetrapeptide alanyl-glutamyl-aspartyl-arginine with general formula: Ala-Glu-Asp-Arg sequence 1 [SEQ ID NO:1], revealing biological activity, which is manifested in the restoration of the myocardium function. There is proposed a pharmacological substance containing an effective amount of tetrapeptide alanyl-glutamyl-aspartyl-arginine with general formula: Ala-Glu-Asp-Arg sequence 1 [SEQ ID NO:1] as an active peptide agent, revealing biological activity, which is manifested by the restoration of myocardium function. Being included in the medication, this substance contributes to the restoration of the myocardium function.
    Type: Grant
    Filed: December 7, 2004
    Date of Patent: February 16, 2010
    Assignee: “Access Bioscience” CJSC
    Inventors: Vladimir Khatskelevich Khavinson, Galina Anatolievna Ryzhak, Evgeny Iosifovich Grigoriev, Irina Yurievna Ryadnova
  • Patent number: 7625870
    Abstract: The invention refers to the medicinal remedies for respiratory system diseases treatment and may be applied as a substance, capable of restoring respiratory organs functions and used for treatment of different forms of lung pathology. There is proposed a biologically active new tetrapeptide alanyl-glutamyl-aspartyl-leucine of the general formula Ala-Glu-Asp-Leu, capable of restoring respiratory organs function. There is proposed a pharmaceutical substance, containing as an active peptide agent an effective amount of tetrapeptide alanyl-glutamyl-aspartyl-leucine of the general formula Ala-Glu-Asp-Leu, which if used in the medical preparation contributes to the restoration of the respiratory organs function.
    Type: Grant
    Filed: December 7, 2004
    Date of Patent: December 1, 2009
    Assignee: “Access Bioscience” CJSC
    Inventors: Vladimir Khatskelevich Khavinson, Galina Anatolievna Ryzhak, Evgeny Iosifovich Grigoriev, Irina Yurievna Ryadnova
  • Publication number: 20090170785
    Abstract: The invention is related to the medicinal means of prevention and correction of age-related disorders of cellular and humoral immunity and may be used as a medication revealing an immunogeroprotective effect. There is proposed a peptide glutamyl-aspartyl-proline with general formula H-Glu-Asp-Pro-OH sequence 1 [SEQ ID NO:1], revealing an immunogeroprotective effect. There is proposed a pharmaceutical composition revealing an immunogeroprotective effect containing an effective amount of peptide glutamyl-aspartyl-proline with general formula H-Glu-Asp-Pro-QH sequence 1 [SEQ ID NO:1] as its active base. In this case such pharmaceutical composition exists in the form suitable for parenteral administration.
    Type: Application
    Filed: March 2, 2007
    Publication date: July 2, 2009
    Applicant: OBSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTYU 'SIA PEPTIDES'
    Inventors: Vladimir Khatskelevich Khavinson, Evgeny Iosifovich Grigoriev, Vladimir Victorovich Malinin, Galina Anatolievna Ryzhak
  • Publication number: 20090105157
    Abstract: The invention is related to the medicinal means of treatment of diseases, traumas, as well as consequences of traumas of the central nervous system, and can be also used as a means of stimulating neurons regeneration. There is proposed a peptide glutamyl-aspartyl-arginine with general formula H-GIu-Asp-Arg-OH sequence 1 [SEQ ID NO:1] capable of stimulating the regeneration of neurons. There is also proposed a pharmaceutical composition stimulating the regeneration of neurons containing peptide glutamyl-aspartyl-arginine with general formula H-GIu-Asp-Arg-OH sequence 1 [SEQ ID NO:1] as its active base, as well as a pharmaceutically acceptable carrier. There is proposed a method of stimulating the regeneration of neurons consisting in the administration to a patient of the pharmaceutical composition, containing peptide glutamyl-aspartyl-arginine with general formula H-Glu-Asp-Arg-OH sequence 1 [SEQ ID NO:1] as its active base, in the dose of 0.
    Type: Application
    Filed: December 4, 2006
    Publication date: April 23, 2009
    Applicant: OBSCHESTVO OGRANICHENNOI OTVETSTENNOSTYU SIA PEPTIDES
    Inventors: Vladimir Khatskelevich Khavinson, Evgeny Iosifovich Grigoriev, Vladimir Victorivich Malinin, Galina Anatolievna Ryzhak
  • Publication number: 20090105158
    Abstract: The invention is related to the medicinal means of prevention and treatment for functional or stress induced disorders, which occur as a result of extreme impacts, and may be used as a medication revealing a stress protective effect. There is proposed a peptide glutamyl-aspartyl-glycine with general formula H-Glu-Asp-Gly-OH sequence 1 [SEQ ID NO:1], revealing a stress protective effect. There is proposed a pharmaceutical composition revealing a stress protective effect, characterized in that such composition contains an effective amount of peptide glutamyl-aspartyl-glycine with general formula H-Glu-Asp-Gly-OH sequence 1 [SEQ ID NO:1] as its active base, as well as a pharmaceutically acceptable carrier. In this case such pharmaceutical composition exists in the form suitable for parenteral or intranasal administration.
    Type: Application
    Filed: March 5, 2007
    Publication date: April 23, 2009
    Applicant: OBSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTYU "SIA PEPTIDES"
    Inventors: Vladimir Khatskelevich Khavinson, Evgeny Iosifovich Grigoriev, Vladimir Victorivich Malinin, Galina Anatolievna Ryzhak
  • Publication number: 20090099098
    Abstract: The invention is related to the medicinal means of correction of metabolic vascular syndrome and diseases, associated with disordered vascular wall permeability and capillaries fragility, and can be used as a means of enhancing capillaries resistance. There is proposed a peptide lysyl-glutamyl-asparagine acid of the general formula H-Lys-Glu-Asp-OH sequence 1 [SEQ ID NO:1], revealing biological activity and capable of enhancing capillaries resistance. There is also proposed a pharmaceutical composition enhancing capillaries resistance, containing effective amount of peptide lysyl-glutamyl-asparagine acid of the general formula H-Lys-Glu-Asp-OH sequence 1 [SEQ ID NO: 1] as its active base and pharmaceutically acceptable carrier. This pharmaceutical composition is in form for parenteral administration.
    Type: Application
    Filed: December 4, 2006
    Publication date: April 16, 2009
    Applicant: OBSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTYU "SIA PEPTIDES"
    Inventors: Vladimir Khatskelevich Khavinson, Evgeny Iosifovich Grigoriev, Vladimir Victorivich Malinin, Galina Anatolievna Ryzhak
  • Patent number: 7491703
    Abstract: The invention refers to the field of medicine and can be applied as a substance capable of regulating glucose level while treating and preventing diabetes mellitus. There is proposed a biologically active new tetrapeptide lysyl-glutamyl-aspartyl-tryp-tophane of general formula Lys-Glu-Asp-Trp-NH2 capable of regulating the glucose level, and pharmacological substance containing an effective amount of tetrapeptide lysyl-glutamyl-aspartyl-tryptophane of the general formula Lys-Glu-Asp-Trp-NH2. There is proposed the method of prevention and/or treatment of the diabetes mellitus, which consists in administering to a patient of the pharmacological substance, containing as an active peptide agent an effective amount of Lys-Glu-Asp-Trp-NH2 tetrapeptide in doses of 0.1-30 ?g/kg of the body weight at least once a day for a period necessary for attaining a therapeutic effect.
    Type: Grant
    Filed: August 9, 2004
    Date of Patent: February 17, 2009
    Assignee: “Access Bioscience” CJSC
    Inventors: Vladimir Khatskelevich Khavinson, Vladimir Viktorovich Malinin, Evgeny Iosifovich Grigoriev, Galina Anatolievna Ryzhak
  • Publication number: 20080274982
    Abstract: The invention refers to the medicinal remedies for respiratory system diseases treatment and may be applied as a substance, capable of restoring respiratory organs functions and used for treatment of different forms of lung pathology. There is proposed a biologically active new tetrapeptide alanyl-glutamyl-aspartyl-leucine of the general formula Ala-Glu-Asp-Leu, capable of restoring respiratory organs function. There is proposed a pharmaceutical substance, containing as an active peptide agent an effective amount of tetrapeptide alanyl-glutamyl-aspartyl-leucine of the general formula Ala-Glu-Asp-Leu, which if used in the medical preparation contributes to the restoration of the respiratory organs function.
    Type: Application
    Filed: December 7, 2004
    Publication date: November 6, 2008
    Inventors: Vladimir Khatskelevich Khavinson, Galina Anatolievna Ryzhak, Evgeny Iosifovich Grigoriev, Irina Yurievna Ryadnova
  • Publication number: 20080269141
    Abstract: The invention refers to the pharmaceutical means for the treatment of cardiovascular diseases and can be used as a substance restoring myocardium function in the course of treatment for different forms of this pathology. There is proposed a new tetrapeptide alanyl-glutamyl-aspartyl-arginine with general formula: Ala-Glu-Asp-Arg sequence 1 [SEQ ID NO:1], revealing biological activity, which is manifested in the restoration of the myocardium function. There is proposed a pharmacological substance containing an effective amount of tetrapeptide alanyl-glutamyl-aspartyl-arginine with general formula: Ala-Glu-Asp-Arg sequence 1 [SEQ ID NO:1] as an active peptide agent, revealing biological activity, which is manifested by the restoration of myocardium function. Being included in the medication, this substance contributes to the restoration of the myocardium function.
    Type: Application
    Filed: December 7, 2004
    Publication date: October 30, 2008
    Applicant: "ACCESS BIOSCIENCE" CJSC
    Inventors: Vladimir Khatskelevich Khavinson, Galina Anatolievna Ryzhak, Evgeny Iosifovich Grigoriev, Irina Yurievna Ryadnova