Patents by Inventor Evgeny Nudler

Evgeny Nudler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nitrosation-Inducible Inhibitors Biological Macromolecules
    Publication number: 20090186829
    Abstract: Biomacromolecules such as proteins are inactivated by hydrophobic ANSA derivatives of the formula: wherein R1 and R2 are hydrophobic or affinity groups and R3 is selected from the group consisting of aminoacyl groups and peptidyl groups upon nitrosation. ANSA derivatives can be designed to selectively kill tumor cells and various pathogens, including bacteria, viruses, and fungi.
    Type: Application
    Filed: March 26, 2009
    Publication date: July 23, 2009
    Applicant: New York University
    Inventors: Evgeny NUDLER, Audrei NEDOSPASOV
  • Nitrosation-inducible inhibitors biological macromolecules
    Patent number: 7511076
    Abstract: Biomacromolecules such as proteins are inactivated by hydrophobic ANSA derivatives of the formula: wherein R1 and R2 are hydrophobic or affinity groups and R3 is selected from the group consisting of aminoacyl groups and peptidyl groups upon nitrosation. ANSA derivatives can be designed to selectively kill tumor cells and various pathogens, including bacteria, viruses, and fungi.
    Type: Grant
    Filed: July 1, 2002
    Date of Patent: March 31, 2009
    Assignee: New York University
    Inventors: Evgeny Nudler, Andrei Nedospasov
  • SHORT PEPTIDES USEFUL FOR TREATMENT OF ISCHEMIA/REPERFUSION INJURY AND OTHER TISSUE DAMAGE CONDITIONS ASSOCIATED WITH NITRIC OXIDE AND ITS REACTIVE SPECIES
    Publication number: 20080182797
    Abstract: This invention discloses isolated short peptides comprising the amino acid sequence Cys-Glu-Phe-His (CEFH) and analogs thereof as well as compositions comprising CEFH peptides and analogs thereof. The CEFH peptides disclosed herein are effective in mediating the denitration of 3-nitrotyrosines (3-NT) in cellular proteins thereby preventing tissue damage associated with excess nitric oxide (NO) and its reactive species. The CEFH peptides disclosed herein are useful in the treatment of ischemia/reperfusion (I/R) injury of various tissues (e.g., I/R injury of heart muscle associated with heart attack or cardiac surgery, I/R injury of brain tissue associated with stroke, I/R injury of liver tissue, skeletal muscles, etc.), septic shock, anaphylactic shock, neurodegenerative diseases (e.g.
    Type: Application
    Filed: May 3, 2007
    Publication date: July 31, 2008
    Applicant: New York University
    Inventors: Evgeny A. Nudler, Ruslan Rafikov
  • HEAT SHOCK RNA AND ITS USE IN ACTIVATION OF HEAT SHOCK TRANSCRIPTION FACTOR AND TREATMENT OF CANCER, INFLAMMATION, ISCHEMIA, NEURODEGENERATION, AGE-RELATED DISEASES, HIV INFECTION, DEAFNESS, AND RELATED DISORDERS
    Publication number: 20070238682
    Abstract: The present invention provides a novel RNA, designated herein as the “HSR1” (Heat Shock RNA), and its use together with translation elongation factor eEF1A in activation of heat shock transcription factor HSF. The invention further provides the use of HSR1 for generation of novel therapeutics for the treatment of cancer, inflammation, ischemia, neurodegeneration, age-related diseases, HIV infection, deafness, and related disorders.
    Type: Application
    Filed: December 18, 2006
    Publication date: October 11, 2007
    Applicant: New York University
    Inventors: Evgeny Nudler, Ilya Shamovsky
  • Nitrosation-inducible inhibitors biological macromolecules
    Publication number: 20030087805
    Abstract: Biomacromolecules such as proteins are inactivated by hydrophobic ANSA derivatives of the formula: 1
    Type: Application
    Filed: July 1, 2002
    Publication date: May 8, 2003
    Applicant: New York University
    Inventors: Evgeny Nudler, Audrei Nedospasov